(19)
(11) EP 2 294 420 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.10.2015 Bulletin 2015/43

(45) Mention of the grant of the patent:
12.08.2015 Bulletin 2015/33

(21) Application number: 09759517.7

(22) Date of filing: 05.06.2009
(51) International Patent Classification (IPC): 
G01N 33/574(2006.01)
(86) International application number:
PCT/US2009/046421
(87) International publication number:
WO 2009/149359 (10.12.2009 Gazette 2009/50)

(54)

Survival predictor for diffuse large B cell lymphoma

Überlebensvorhersage für diffuse großzellige B-Zell-Lymphome

Indice de survie pour un lymphome diffus à grandes cellules B


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(30) Priority: 06.06.2008 US 59678 P

(43) Date of publication of application:
16.03.2011 Bulletin 2011/11

(60) Divisional application:
15180558.7

(73) Proprietors:
  • The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
    Bethesda, MD 20892-7660 (US)
  • British Columbia Cancer Agency Branch
    Vancouver, British Columbia V5Z 4E6 (CA)
  • UNIVERSITY OF ROCHESTER
    Rochester, NY 14642 (US)
  • Oregon Health & Science University
    Portland, OR 97201 (US)
  • Arizona Board of Regents on behalf of The University of Arizona
    Tucson, AZ 85721 (US)
  • Queen Mary And Westfield College, University Of London
    London E1 4NS (GB)
  • Board of Regents of the University of Nebraska
    Lincoln, Nebraska 68583-0745 (US)
  • Universitat de Barcelona Hospital Clinic
    08028 Barcelona (ES)
  • Oslo University Hospital HF
    0151 Oslo (NO)
  • Julius-Maximilians-University of Wuerzburg
    97070 Wuerzburg (DE)
  • Hospital Clinic
    Barcelona 08036 (ES)

(72) Inventors:
  • STAUDT, Louis, M.
    Silver Springs,MD 20910 (US)
  • RIMSZA, Lisa
    Tucsun, Arizona 85749 (US)
  • LISTER, Andrew T.
    Greenwich, London SE10 8QN (GB)
  • WEISENBURGER, Dennis
    Elkhorn, Nebraska 68022 (US)
  • DELABIE, Jan
    Omaha, Nebraska 68124 (US)
  • SMELAND, Erlend B.
    0286 Oslo (NO)
  • HOLTE, Harald
    0779 Oslo (NO)
  • KVALOY, Stein
    1185 Oslo (NO)
  • BRAZIEL, Rita M.
    West Linn, OR 97068 (US)
  • FISHER, Richard I.
    Pittsford, NY 14534 (US)
  • JARES, Pedro
    08042 Barcelona (ES)
  • LOPEZ-GUILLERMO, Armando
    08017 Barcelona (ES)
  • GUERRI, Elias Campo
    08036 Barcelona (ES)
  • JAFFE, Elaine S.
    Great Falls, VA 22066 (US)
  • LENZ, Georg
    13158 Berlin (DE)
  • WYNDHAM, H.Wilson.
    Washington, DC 20015 (US)
  • WRIGHT, George
    Rockville, MD 20853 (US)
  • DAVE, Sandeep S.
    Chapel Hill, NC 27514 (US)
  • GASCOYNE, Randy D.
    North Vancouver BC V7M 1S3 (CA)
  • CONNORS, Joseph M.
    Vancouver, BC V6S 1P4 (CA)
  • MÜLLER-HERMELINK, Hans-Konrad
    97082 Würzburg (DE)
  • ROSENWALD, Andreas
    97078 Würzburg (DE)
  • OTT, German
    74321 Bietigheim-Bissingen (DE)
  • WING, C Chan
    Omaha, NE 68124 (US)

(74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB 
Leopoldstraße 4
80802 München
80802 München (DE)


(56) References cited: : 
WO-A-2005/024043
   
  • ROSENWALD ANDREAS ET AL: "The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma." THE NEW ENGLAND JOURNAL OF MEDICINE 20 JUN 2002, vol. 346, no. 25, 20 June 2002 (2002-06-20), pages 1937-1947, XP002551774 ISSN: 1533-4406 cited in the application
  • MAHADEVAN DARUKA ET AL: "Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures." MOLECULAR CANCER THERAPEUTICS DEC 2005, vol. 4, no. 12, December 2005 (2005-12), pages 1867-1879, XP002551775 ISSN: 1535-7163
  • ANONYMOUS: "Lymphoma microenvironment impacts therapy and prognosis" INTERNET ARTICLE, [Online] 16 June 2008 (2008-06-16), pages 1-3, XP002551773 Retrieved from the Internet: URL:http://www.hematologytimes.com/ht/p_ar ticle.do?id=437&sid=2005911274> [retrieved on 2009-10-22]
  • LENZ G ET AL: "Stromal gene signatures in large-B-cell lymphomas." THE NEW ENGLAND JOURNAL OF MEDICINE 27 NOV 2008, vol. 359, no. 22, 27 November 2008 (2008-11-27), pages 2313-2323, XP002551776 ISSN: 1533-4406 -& LENZ G ET AL: "Supplementary Appendix" THE NEW ENGLAND JOURNAL OF MEDICINE 27 NOV 2008, vol. 359, no. 22, 27 November 2008 (2008-11-27), pages 2313-2323, XP002551777 ISSN: 1533-4406
   
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