(19)
(11) EP 2 294 918 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.11.2012 Bulletin 2012/46

(45) Mention of the grant of the patent:
10.10.2012 Bulletin 2012/41

(21) Application number: 10183935.5

(22) Date of filing: 29.08.2000
(27) Previously filed application:
 29.08.2000 EP 08168000
(51) International Patent Classification (IPC): 
C12N 9/22(2006.01)
 A61K 38/46(2006.01)

(54)

Use of a ribonuclease of the T2 family having actin-binding activity for inhibiting tumor angiogenesis

Gebrauch einer Ribonuclease der T2-Familie mit Actin-bindender Aktivität zur Hemmung der Tumorangiogenese

Utilisation d'une ribonucléase de la famille t2 ayant une activité de fixation à l'actine pour inhiber l'angiogenèse de tumeurs

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 30.08.1999 US 385411

(43) Date of publication of application:
16.03.2011 Bulletin 2011/11

(62) Application number of the earlier application in accordance with Art. 76 EPC:
08168000.1 / 2165605
00954879.3 / 1207755

(73) Proprietor: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
91390 Jerusalem (IL)

(72) Inventors:
  • Roiz, Levava
    55654, Kiryat-Ono (IL)
  • Shoseyov, Oded
    99797, Karmei Yosef (IL)
  • Schwartz, Betty
    76667, Rechovot (IL)
  • Smirnoff, Patricia
    76823, Rehovot (IL)

(74) Representative: Fichter, Robert Arno 
Dennemeyer & Associates S.A. 55, rue des Bruyères
1274 Howald
1274 Howald (LU)


(56) References cited: : 
EP-B1- 1 207 755
US-A- 5 786 457
 WO-A2-2006/035439
   
  • KAWATA-Y ET AL.: "AMINO-ACID SEQUENCE OF RIBONUCLEASE T2 FROM ASPERGILLUS ORYZAE", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 176, 1988, pages 683-697, XP002935748, Berlin, De
  • KAWATA Y ET AL: "IDENTIFICATION OF TWO ESSENTIAL HISTIDINE RESIDUES OF RNASE T-2 FROM ASPERGILLUS-ORYZAE", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 187, no. 1, 1990, pages 255-262, XP008009203, ISSN: 0014-2956
  • NOMACHI Y ET AL: "PURIFICATION AND SOME PROPERTIES OF 2 ACID RNASE FRACTIONS EC-3.1.27.1 EC-3.1.27.3 FROM THE MYCELIA OF ASPERGILLUS-NIGER", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, vol. 26, no. 6, 1980, pages 375-386, XP008009205, ISSN: 0022-1260
  • LACCETTI P ET AL: "SEMINAL RIBONUCLEASE INHIBITS TUMOR GROWTH AND REDUCES THE METASTATIC POTENTIAL OF LEWIS LUNG CARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 54, 15 August 1994 (1994-08-15), pages 4253-4256, XP002000755, ISSN: 0008-5472
  • IRIE M: "STRUCTURE-FUNCTION RELATIONSHIPS OF ACID RIBONUCLEASES: LYSOSOMAL, VACUOLAR, AND PERIPLASMIC ENZYMES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 81, no. 2, 1 January 1999 (1999-01-01), pages 77-89, XP002935746, ISSN: 0163-7258
  • MASTRONICOLA M R ET AL: "Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS 15 MAY 1995, vol. 230, no. 1, 15 May 1995 (1995-05-15), pages 242-249, XP002565611, ISSN: 0014-2956
  • TRUBIA M ET AL: "Mammalian Rh/T2/S-Glycoprotein Ribonuclease Family Genes: Cloning of a Human Member Located in a Region of Chromosome 6 (6q27) Frequently Deleted in Human Malignancies", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 42, no. 2, 1 June 1997 (1997-06-01), pages 342-344, XP004459303, ISSN: 0888-7543
  • FETT J W ET AL: "Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells.", BIOCHEMISTRY 24 SEP 1985 LNKD- PUBMED:4074709, vol. 24, no. 20, 24 September 1985 (1985-09-24), pages 5480-5486, XP002618087, ISSN: 0006-2960
  • ACQUATI FRANCESCO ET AL: "Tumor and metastasis suppression by the human RNASET2 gene.", INTERNATIONAL JOURNAL OF ONCOLOGY MAY 2005, vol. 26, no. 5, May 2005 (2005-05), pages 1159-1168, XP009068627, ISSN: 1019-6439
  • LELAND P A ET AL: "Cancer chemotherapy--ribonucleases to the rescue.", CHEMISTRY & BIOLOGY MAY 2001, vol. 8, no. 5, May 2001 (2001-05), pages 405-413, XP002565612, ISSN: 1074-5521
  • DESHPANDE R A ET AL: "RIBONUCLEASES FROM T2 FAMILY", CRITICAL REVIEWS IN MICROBIOLOGY, CRC PRESS, INC., BOCA RATON, FL, US, vol. 28, no. 2, 1 June 2002 (2002-06-01), pages 79-122, XP008009078,
  • LUHTALA NATALIE ET AL: "T2 Family ribonucleases: ancient enzymes with diverse roles.", TRENDS IN BIOCHEMICAL SCIENCES MAY 2010 LNKD- PUBMED:20189811, vol. 35, no. 5, May 2010 (2010-05), pages 253-259, XP002618088, ISSN: 0968-0004
  • ROIZ LEVAVA ET AL: "ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.", CANCER 15 MAY 2006 LNKD- PUBMED:16586499, vol. 106, no. 10, 15 May 2006 (2006-05-15) , pages 2295-2308, XP002618089, ISSN: 0008-543X
   
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