ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY....................................................JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/02294918CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120121114W172 73deBibliographieenBibliographyfrBibliographieEP10183935.52000082920100930enenen0816800020000829EP38541119990830US2012111420124620110316201111201210102012412012050420121114201246C12N 9/22 20060101AFI20120208BHEP A61K 38/46 20060101ALI20120208BHEP deGebrauch einer Ribonuclease der T2-Familie mit Actin-bindender Aktivität zur Hemmung der TumorangiogeneseenUse of a ribonuclease of the T2 family having actin-binding activity for inhibiting tumor angiogenesisfrUtilisation d'une ribonucléase de la famille t2 ayant une activité de fixation à l'actine pour inhiber l'angiogenèse de tumeursEP-B1- 1 207 755WO-A2-2006/035439US-A- 5 786 457KAWATA-Y ET AL.: "AMINO-ACID SEQUENCE OF RIBONUCLEASE T2 FROM ASPERGILLUS ORYZAE", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 176, 1988, pages 683-697, XP002935748, Berlin, DeKAWATA Y ET AL: "IDENTIFICATION OF TWO ESSENTIAL HISTIDINE RESIDUES OF RNASE T-2 FROM ASPERGILLUS-ORYZAE", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 187, no. 1, 1990, pages 255-262, XP008009203, ISSN: 0014-2956NOMACHI Y ET AL: "PURIFICATION AND SOME PROPERTIES OF 2 ACID RNASE FRACTIONS EC-3.1.27.1 EC-3.1.27.3 FROM THE MYCELIA OF ASPERGILLUS-NIGER", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, vol. 26, no. 6, 1980, pages 375-386, XP008009205, ISSN: 0022-1260LACCETTI P ET AL: "SEMINAL RIBONUCLEASE INHIBITS TUMOR GROWTH AND REDUCES THE METASTATIC POTENTIAL OF LEWIS LUNG CARCINOMA", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 54, 15 August 1994 (1994-08-15), pages 4253-4256, XP002000755, ISSN: 0008-5472IRIE M: "STRUCTURE-FUNCTION RELATIONSHIPS OF ACID RIBONUCLEASES: LYSOSOMAL, VACUOLAR, AND PERIPLASMIC ENZYMES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 81, no. 2, 1 January 1999 (1999-01-01), pages 77-89, XP002935746, ISSN: 0163-7258MASTRONICOLA M R ET AL: "Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS 15 MAY 1995, vol. 230, no. 1, 15 May 1995 (1995-05-15), pages 242-249, XP002565611, ISSN: 0014-2956TRUBIA M ET AL: "Mammalian Rh/T2/S-Glycoprotein Ribonuclease Family Genes: Cloning of a Human Member Located in a Region of Chromosome 6 (6q27) Frequently Deleted in Human Malignancies", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 42, no. 2, 1 June 1997 (1997-06-01), pages 342-344, XP004459303, ISSN: 0888-7543FETT J W ET AL: "Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells.", BIOCHEMISTRY 24 SEP 1985 LNKD- PUBMED:4074709, vol. 24, no. 20, 24 September 1985 (1985-09-24), pages 5480-5486, XP002618087, ISSN: 0006-2960ACQUATI FRANCESCO ET AL: "Tumor and metastasis suppression by the human RNASET2 gene.", INTERNATIONAL JOURNAL OF ONCOLOGY MAY 2005, vol. 26, no. 5, May 2005 (2005-05), pages 1159-1168, XP009068627, ISSN: 1019-6439LELAND P A ET AL: "Cancer chemotherapy--ribonucleases to the rescue.", CHEMISTRY & BIOLOGY MAY 2001, vol. 8, no. 5, May 2001 (2001-05), pages 405-413, XP002565612, ISSN: 1074-5521DESHPANDE R A ET AL: "RIBONUCLEASES FROM T2 FAMILY", CRITICAL REVIEWS IN MICROBIOLOGY, CRC PRESS, INC., BOCA RATON, FL, US, vol. 28, no. 2, 1 June 2002 (2002-06-01), pages 79-122, XP008009078,LUHTALA NATALIE ET AL: "T2 Family ribonucleases: ancient enzymes with diverse roles.", TRENDS IN BIOCHEMICAL SCIENCES MAY 2010 LNKD- PUBMED:20189811, vol. 35, no. 5, May 2010 (2010-05), pages 253-259, XP002618088, ISSN: 0968-0004ROIZ LEVAVA ET AL: "ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.", CANCER 15 MAY 2006 LNKD- PUBMED:16586499, vol. 106, no. 10, 15 May 2006 (2006-05-15) , pages 2295-2308, XP002618089, ISSN: 0008-543X08168000.121656052008103100954879.3120775520000829Roiz, Levava 9/38 Shaul HaMelech Street55654, Kiryat-OnoILShoseyov, Oded 5 Erez Street99797, Karmei YosefILSchwartz, Betty 6/2 Itzhak Ben-Ari Road76667, RechovotILSmirnoff, Patricia 17/7 Glazer Street76823, RehovotILYissum Research Development Company of the Hebrew University of Jerusalem Ltd.101135792F-11982/EP/3Hi Tech Park The Edmond J. Safra Campus The Hebrew University of Jerusalem Givat Ram91390 JerusalemILFichter, Robert Arno101045029Dennemeyer & Associates S.A. 55, rue des Bruyères1274 HowaldLUATBECHCYDEDKESFIFRGBGRIEITLILUMCNLPTSE20110316201111