(19)

(11)

EP 2 297 206 A1

(12)

(43) Date of publication: 23.03.2011 Bulletin 2011/12 (21) Application number: 09747210.4 (22) Date of filing: 07.05.2009

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2009/043063 (87) International publication number: WO 2009/140124 (19.11.2009 Gazette 2009/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 14.05.2008 US 53192 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46285 (US)

(72) Inventors: DICKERSON, Cindy, Takeuchi Indianapolis, IN 46285 (US) MARQUIS, David, Matthew Encitas CA 92024 (US) OBUNGU, Victor Indianapolis, IN 46285 (US) PENG, Sheng-Bin Indianapolis, IN 46285 (US) VAILLANCOURT, Peter, Edward Indianapolis, IN 46285 (US) (74) Representative: Commander, Paul Martin Brial et al Eli Lilly and Company Limited Lilly Research Centre Erl Wood Manor Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)