(19)

(11)

EP 2 297 332 A2

(12)

(88) Date of publication A3: 11.03.2010 (43) Date of publication: 23.03.2011 Bulletin 2011/12 (21) Application number: 09763772.2 (22) Date of filing: 12.06.2009

(51) International Patent Classification (IPC):  C12Q 1/02(2006.01) G01N 33/15(2006.01) C12N 5/08(0000.00) (86) International application number: PCT/US2009/047291 (87) International publication number: WO 2009/152484 (17.12.2009 Gazette 2009/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 13.06.2008 US 61592 P 13.06.2008 US 61594 P (71) Applicant: Izumi Bio, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: SAKURADA, Kazuhiro Yokohama, 225-0016 (JP) SEIDENMAN, Kenneth, J. San Diego,CA 92129 (US) (74) Representative: Wilkinson, Marc George et al HLBBshaw Merlin House Falconry Court Baker's Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)