(19)

(11)

EP 2 297 341 A1

(12)

(43) Date of publication: 23.03.2011 Bulletin 2011/12 (21) Application number: 09741640.8 (22) Date of filing: 08.05.2009

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) A61K 31/713(2006.01) C12N 15/63(2006.01) G01N 33/53(2006.01) C07H 21/00(2006.01) A61K 31/7088(2006.01) A61P 25/14(2006.01) C12N 15/85(2006.01) G01N 33/68(2006.01) C12N 15/11(2006.01) (86) International application number: PCT/CA2009/000645 (87) International publication number: WO 2009/135322 (12.11.2009 Gazette 2009/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 09.05.2008 US 714652 P (71) Applicant: The University of British Columbia Vancouver, BC V6T 1Z3 (CA)	(72) Inventors: HAYDEN, Michael Vancouver British Columbia V6R 1W9 (CA) CARROLL, Jeffrey Vancouver British Columbia V6K 3C4 (CA) WARBY, Simon Vancouver British Columbia V5Z 1S4 (CA) (74) Representative: Baldock, Sharon Claire  Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)