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(11)

EP 2 299 976 A2

(12)

(88) Date of publication A3: 21.10.2010 (43) Date of publication: 30.03.2011 Bulletin 2011/13 (21) Application number: 09835529.0 (22) Date of filing: 10.12.2009

(51) International Patent Classification (IPC):  A61K 9/127(2006.01) A61K 47/34(2006.01) A61K 9/16(2006.01) A61P 27/16(2006.01) (86) International application number: PCT/US2009/067552 (87) International publication number: WO 2010/074992 (01.07.2010 Gazette 2010/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 22.12.2008 US 140033 P 13.03.2009 US 160233 P 30.03.2009 US 164812 P 24.04.2009 GB 0907070 30.04.2009 US 174421 P 16.07.2009 US 504553 (71) Applicants: Otonomy, Inc. San Diego, CA 92121 (US) The Regents of the University of California Oakland, CA 94607 (US)

(72) Inventors: LICHTER, Jay Rancho Santa Fe California 92067 (US) VOLLRATH, Benedikt San Diego California 92107 (US) TRAMMEL, Andrew, M. Olathe Kansas 66062 (US) DURÓN, Sergio, G. San Diego California 92103 (US) PIU, Fabrice San Diego California 92131 (US) DELLAMARY, Luis, A. San Marcos California 92069 (US) YE, Qiang San Diego California 92129 (US) LEBEL, Carl Malibu California 90265 (US) SCAIFE, Michael, Christopher Los Altos California 94022 (US) HARRIS, Jeffrey, P. La Jolla California 92037 (US) (74) Representative: Sahans, Sarah Anne et al HLBBshaw Merlin House Falconry Court Baker's Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)