ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................JJDIM360 Ver 1.28 (29 Oct 2014) - 2999001/0201610282301570CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120170125W122deBibliographieenBibliographyfrBibliographieEP10012296.9200312312010093020131018enenen437145 P20021231US2017012520170420110330201113201601272016042015071420160127AT20160127BE20160127CZ20160127DK20160127EE20160127ES20160127FI20160428GR20160127IT20160127NL20160527PT20160127RO20160127SE20160127SK20170125201704A61K 51/10 20060101AFI20150602BHEP C07K 16/28 20060101ALI20150602BHEP deImmunotherapie von B-zell Tumoren und Autoimmunerkrankungen unter Verwendung von unkonjugierten und konjugierten Antikörpern sowie Antikörperkombinationen und FusionsproteinenenImmunotherapy of B cell malignancies and autoimmune diseases using unconjugated and conjugated antibodies, antibody combinations and fusion proteinfrImmunothérapie s'appliquant aux tumeurs malignes des lymphocytes B et maladies auto-immunes utilisant des anticorps non conjugués et des anticorps conjugués, des combinaisons d'anticorps et des protéines de fusionWO-A-00/67796WO-A-00/74718WO-A-01/97855WO-A-01/97858WO-A-98/42378WO-A1-00/67795PRESS O W: "PROSPECTS FOR THE MANAGEMENT OF NON-HODGKIN'S LYMPHOMAS WITH MONOCLONAL ANTIBODIES AND IMMUNOCONJUGATES", CANCER JOURNAL FROM SCIENTIFIC AMERICAN, SCIENTIFIC AMERICAN, INC., NEW YORK, NY, US, vol. 4, no. SUPPL 2, July 1998 (1998-07), pages S19-S26, XP000929567, ISSN: 1081-4442SHIH L ET AL: "Localization of an antibody to CD74 (MHC class II invariant chain) to human B cell lymphoma xenografts in nude mice.", CANCER IMMUNOLOGY, IMMUNOTHERAPY : CII JUL 2000 LNKD- PUBMED:10941903, vol. 49, no. 4-5, July 2000 (2000-07), pages 208-216, XP002619710, ISSN: 0340-7004GRIFFITHS G L ET AL: "Cytotoxicity with Auger electron-emitting radionuclides delivered by antibodies.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 11 JUN 1999 LNKD- PUBMED:10362149, vol. 81, no. 6, 11 June 1999 (1999-06-11), pages 985-992, XP002619711, ISSN: 0020-7136GOVINDAN S V ET AL: "Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters.", JOURNAL OF NUCLEAR MEDICINE : OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE DEC 2000 LNKD- PUBMED:11138697, vol. 41, no. 12, December 2000 (2000-12), pages 2089-2097, XP002619712, ISSN: 0161-5505OCHAKOVSKAYA R ET AL: "Therapy of disseminated B-cell lymphoma xenografts in severe combined immunodeficient mice with an anti-CD74 antibody conjugated with (111)indium, (67)gallium, or (90)yttrium.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH JUN 2001 LNKD- PUBMED:11410483, vol. 7, no. 6, June 2001 (2001-06), pages 1505-1510, XP002619713, ISSN: 1078-0432PRESS O W ET AL: "Immunotherapy of Non-Hodgkin's lymphomas.", HEMATOLOGY / THE EDUCATION PROGRAM OF THE AMERICAN SOCIETY OF HEMATOLOGY. AMERICAN SOCIETY OF HEMATOLOGY. EDUCATION PROGRAM. UNITED STATES 2001, 2001, pages 221-240, XP002276291, ISSN: 1520-4391TIETZE L F ET AL: "Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy.", CHEMBIOCHEM: A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY. GERMANY 4 MAY 2001, vol. 2, no. 5, 4 May 2001 (2001-05-04), pages 326-334, XP002276289, ISSN: 1439-4227ILLIDGE T M ET AL: "RADIOIMMUNOTHERAPY OF CANCER: USING MONOCLONAL ANTIBODIES TO TARGET RADIOTHERAPY", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, SCHIPHOL, NL, vol. 6, no. 14, September 2000 (2000-09), pages 1399-1418, XP008020510, ISSN: 1381-6128ONG G L ET AL: "Single-cell cytotoxicity with radiolabeled antibodies.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH JAN 2001 LNKD- PUBMED:11205908, vol. 7, no. 1, January 2001 (2001-01), pages 192-201, XP002619714, ISSN: 1078-0432PRESTA L G: "ENGINEERING ANTIBODIES FOR THERAPY", CURRENT PHARMACEUTICAL BIOTECHNOLOGY, BENTHAM SCIENCE PUBLISHERS, BOCA RATON,FL, US, vol. 3, no. 3, 2002, pages 237-256, XP001105189, ISSN: 1389-2010REDDI ELENA: "Role of delivery vehicles for photosensitizers in the photodynamic therapy of tumours", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B BIOLOGY, vol. 37, no. 3, 1997, pages 189-195, XP002276288, ISSN: 1011-1344DE VITA SALVATORE ET AL: "Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells.", ARTHRITIS AND RHEUMATISM. UNITED STATES AUG 2002, vol. 46, no. 8, August 2002 (2002-08), pages 2029-2033, XP002276292, ISSN: 0004-3591STEIN R ET AL: "CD74: A new candidate target for the immunotherapy of B-cell neoplasms", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 18, 15 September 2007 (2007-09-15), pages 5556s-5563s, XP002510850, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-07-1167L. Alinari ET AL: "Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma", Blood, vol. 117, no. 17, 28 April 2011 (2011-04-28), pages 4530-4541, XP055142749, ISSN: 0006-4971, DOI: 10.1182/blood-2010-08-303354GUPTA PANKAJ ET AL: "Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas", BLOOD, vol. 119, no. 16, April 2012 (2012-04), pages 3767-3778, ISSN: 0006-4971(print)Pankaj Gupta ET AL: "Abstract 4572: Heterodimerization of CD74 and CD20 by two hexavalent, bispecific, anti-CD20/CD74 antibodies leads to potent cytotoxicity in mantle cell lymphoma", Cancer research, vol. 71, no. 8 Supplement, 15 April 2011 (2011-04-15), pages 4572-4572, XP055193106, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2011-457203786167.1157844020031231Goldenberg, David M.c/o Immunomedics Inc. 300 American RoadMorris Plains New Jersey 07950USHansen, Hansc/o Immunomedics Inc. 300 American RoadMorris Plains New Jersey 07950USImmunomedics, Inc.100145131I 10013 EP/D-I300 American RoadMorris Plains, NJ 07950USBohmann, Armin K.100046635Bohmann Anwaltssozietät Nymphenburger Straße 180335 MünchenDEATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEITLILUMCNLPTROSESISKTR20110330201113