(19)

(11)

EP 2 303 002 A2

(12)

(88) Date of publication A3: 21.01.2010 (43) Date of publication: 06.04.2011 Bulletin 2011/14 (21) Application number: 09750955.8 (22) Date of filing: 18.05.2009

(51) International Patent Classification (IPC):  A01K 67/027(2006.01) C12N 5/10(2006.01) G01N 33/50(2006.01) (86) International application number: PCT/US2009/003094 (87) International publication number: WO 2009/142724 (26.11.2009 Gazette 2009/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA RS (30) Priority: 19.05.2008 US 128110 P (71) Applicant: Beth Israel Deaconess Medical Center, Inc. Boston, MA 02215 (US)	(72) Inventors: LOWELL, Bradford, B. Southborough, MA 01772 (US) DHILLON, Harveen Waltham, MA 02453 (US) (74) Representative: Baldock, Sharon Claire  Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)