(19)
(11) EP 2 308 978 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
08.04.2015 Bulletin 2015/15

(45) Mention of the grant of the patent:
25.02.2015 Bulletin 2015/09

(21) Application number: 10182746.7

(22) Date of filing: 01.10.2004
(51) International Patent Classification (IPC): 
C12N 15/53(2006.01)
C12Q 1/66(2006.01)
 C12N 9/02(2006.01)
G01N 33/573(2006.01)

(54)

Luciferase biosensor

LUCIFERASE BIOSENSOR

Biocapteur à la luciférase

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30) Priority: 10.10.2003 US 510187 P

(43) Date of publication of application:
13.04.2011 Bulletin 2011/15

(62) Application number of the earlier application in accordance with Art. 76 EPC:
04809862.8 / 1673459

(73) Proprietor: Promega Corporation
Madison, WI 53711 (US)

(72) Inventors:
  • Fan, Frank
    Verona, WI 53593 (US)
  • Lewis, Martin Ken
    deceased (US)
  • Schultz, John W.
    Verona, WI 53595 (US)
  • Wood, Keith V.
    Madison, WI 53711 (US)
  • Butler, Braeden
    Madison, WI 53704 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)


(56) References cited: : 
WO-A2-02/059262
   
  • OZAWA T ET AL: "SPLIT LUCIFERASE AS AN OPTICAL PROBE FOR DETECTING PROTEIN-PROTEIN INTERACTIONS IN MAMMALIAN CELLS BASED ON PROTEIN SPLICING", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 73, no. 11, 1 June 2001 (2001-06-01), pages 2516-2521, XP001081130, ISSN: 0003-2700
  • BURBELO P D ET AL: "DETECTING PROTEIN-PROTEIN INTERACTIONS USING RENILLA LUCIFERASE FUSION PROTEINS", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 33, no. 5, November 2002 (2002-11), pages 1044-1049, XP008028120, ISSN: 0736-6205
  • PAULMURUGAN R ET AL: "Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 99, no. 24, 26 November 2002 (2002-11-26), pages 15608-15613, XP002980935, ISSN: 0027-8424
  • PAULMURUGAN R ET AL: "MONITORING PROTEIN-PROTEIN INTERACTIONS USING SPLIT SYNTHETIC RENILLA LUCIFERASE PROTEIN-FRAGMENT-ASSISTED COMPLEMENTATION", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 75, no. 7, 1 April 2003 (2003-04-01), pages 1584-1589, XP001170664, ISSN: 0003-2700
  • SPOTTS JAMES M ET AL: "Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 23, 12 November 2002 (2002-11-12), pages 15142-15147, XP002351604, ISSN: 0027-8424
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).