| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO
PL PT RO SE SI SK TR |
| (30) |
Priority: |
25.04.2008 US 48152 P
28.04.2008 US 48500 P
|
| (43) |
Date of publication of application: |
|
20.04.2011 Bulletin 2011/16 |
| (60) |
Divisional application: |
|
17195757.4 |
| (73) |
Proprietors: |
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- Dyax Corp.
Burlington, MA 01803 (US)
- Biogen Hemophilia Inc.
Waltham, MA 02451 (US)
|
|
| (72) |
Inventors: |
|
- TENHOOR, Christopher
Hopkinton
MA 01748 (US)
- MURUGANANDAM, Arumugam
Bangalore 560035 (IN)
- LADNER, Robert, Charles
Ijamsville
MD 21754 (US)
- WOOD, Clive
Boston, MA 02114 (US)
- BITONTI, Alan, J.
Acton
MA 01720 (US)
- STATTEL, James
Hagerstown
MD 21740 (US)
- MCDONNELL, Kevin
Waltham
MA 02451 (US)
- LIU, Liming
Upper Dublin
PA 19002 (US)
- DUMONT, Jennifer
Groton
MA 01450 (US)
- SATO, Aaron
Richmond
CA 94805 (US)
|
| (74) |
Representative: Carpmaels & Ransford LLP |
|
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB) |
| (56) |
References cited: :
WO-A-2006/118772
US-A1- 2007 092 507
|
WO-A-2007/087289
|
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| |
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- LIU LIMING ET AL: "Amelioration of experimental autoimmune myasthenia gravis in rats
by neonatal FcR blockade" JOURNAL OF IMMUNOLOGY, vol. 178, no. 8, April 2007 (2007-04),
pages 5390-5398, XP009124948 ISSN: 0022-1767
- GETMAN KATE E ET AL: "Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats:
implications for the use of FcRn inhibitors for the treatment of humoral autoimmune
and alloimmune conditions" JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL
ASSOCIATION, WASHINGTON, US, vol. 94, no. 4, 1 April 2005 (2005-04-01), pages 718-729,
XP002417287 ISSN: 0022-3549
- LI NING ET AL: "Complete FcRn dependence for intravenous Ig therapy in autoimmune
skin blistering diseases" JOURNAL OF CLINICAL INVESTIGATION, vol. 115, no. 12, December
2005 (2005-12), pages 3440-3450, XP009124853 ISSN: 0021-9738
- AKILESH SHREERAM ET AL: "The MHC class I-like Fc receptor promotes humorally mediated
autoimmune disease" JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL
INVESTIGATION, US, vol. 113, no. 9, 1 May 2004 (2004-05-01), pages 1328-1333, XP002417288
ISSN: 0021-9738
- ROOPENIAN DERRY C ET AL: "FcRn: the neonatal Fc receptor comes of age" NATURE REVIEWS.
IMMUNOLOGY, XX, XX, vol. 7, no. 9, 1 September 2007 (2007-09-01), pages 715-725, XP002510057
ISSN: 1474-1733
- LORIN ROSKOS ET AL: "Molecular Engineering II: Antibody Affinity", HANDBOOK OF THERAPEUTIC
ANTIBODIES, WILEY-VCH, WEINHEIM, no. Part I, Chapter 7, 30 March 2007 (2007-03-30),
XP007912251, ISBN: 978-3-527-31453-9 [retrieved on 2008-02-01]
- STEPHAN DUEBEL ED - STEFAN DÜBEL: "Handbook of Therapeutic Antibodies Chapter 6",
1 January 2007 (2007-01-01), HANDBOOK OF THERAPEUTIC ANTIBODIES, WILEY-VCH, WEINHEIM,
PAGE(S) 119 - 144, XP007913671, ISBN: 978-3-527-31453-9
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