METHOD FOR CONTROLLING pH, OSMOLALITY AND DISSOLVED CARBON DIOXIDE LEVELS IN A MAMMALIAN CELL CULTURE PROCESS TO ENHANCE CELL VIABILITY AND BIOLOGIC PRODUCT YIELD - Patent 2310493

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EP 2 310 493 A1

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(43)	Date of publication:
	20.04.2011 Bulletin 2011/16

(21)	Application number: 09791207.5

(22)	Date of filing: 06.08.2009

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International Patent Classification (IPC):

C12N 5/07^(2010.01)

(86)	International application number:
	PCT/US2009/052912

(87)	International publication number:
	WO 2010/017338 (11.02.2010 Gazette 2010/06)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
	Designated Extension States:
	AL BA RS

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Priority:

06.08.2008 US 86685 P

(71)	Applicant: Praxair Technology, Inc.
	Danbury, CT 06810 (US)

(72)	Inventors:
	CHENG, Alan, T. Y. Naperville IL 60564 (US) ZHOU, Ying Naperville IL 60565 (US) GUPTA, Amitabh Naperville IL 60564 (US) HUNEK, Balazs Chicago IL 60614 (US) GRINTER, Nigel Buffalo Grove IL 60089 (US)

(74)	Representative: Schwan, Ivo
	Schwan Schwan Schorer Patentanwälte Bauerstrasse 22 80796 München 80796 München (DE)

(54)	METHOD FOR CONTROLLING pH, OSMOLALITY AND DISSOLVED CARBON DIOXIDE LEVELS IN A MAMMALIAN CELL CULTURE PROCESS TO ENHANCE CELL VIABILITY AND BIOLOGIC PRODUCT YIELD