(19)

(11)

EP 2 315 778 A2

(12)

(88) Date of publication A3: 27.05.2010 (43) Date of publication: 04.05.2011 Bulletin 2011/18 (21) Application number: 09784717.2 (22) Date of filing: 17.07.2009

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 37/06(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/GB2009/001762 (87) International publication number: WO 2010/007376 (21.01.2010 Gazette 2010/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 18.07.2008 US 176036 18.07.2008 US 7553 P (71) Applicant: Domantis Limited Brentford, Middlesex TW8 9GS (GB)	(72) Inventors: ENEVER, Carolyn Cambridge CB4 0WG (GB) GRANT, Steven Cambridge CB4 0WG (GB) SANSOM, David Bimingham B15 2TT (GB) HOLMES, Steve Cambridge CB4 0WG (GB) (74) Representative: Smith, Stephen Edward  Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)