(19)

(11)

EP 2 320 934 A2

(12)

(88) Date of publication A3: 06.05.2010 (43) Date of publication: 18.05.2011 Bulletin 2011/20 (21) Application number: 09805458.8 (22) Date of filing: 04.08.2009

(51) International Patent Classification (IPC):  A61K 38/19(2006.01) A61K 38/18(2006.01) A61P 25/28(2006.01) A61K 38/20(2006.01) (86) International application number: PCT/US2009/052742 (87) International publication number: WO 2010/017224 (11.02.2010 Gazette 2010/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 05.08.2008 US 86351 P (71) Applicant: University of South Florida Tampa, FL 33612-9220 (US)	(72) Inventors: POTTER, Huntington Tampa FL 33629 (US) ARENDASH, Gary, W. Cathedral City CA 92234 (US) BENNETT, Steven Tampa FL 33647 (US) BOYD, Timothy Seffner FL 33584-4012 (US) (74) Representative: Jappy, John William Graham  Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES London EC2A 2ES (GB)