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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCY..TRBGCZEEHUPLSK..HRIS..MTNO....SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.40 (30 Jan 2013) -  2999001/0</B007EP></eptags></B000><B100><B110>2321430</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20131225</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>09781439.6</B210><B220><date>20090803</date></B220><B240><B241><date>20110204</date></B241><B242><date>20110624</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>86019 P</B310><B320><date>20080804</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20131225</date><bnum>201352</bnum></B405><B430><date>20110518</date><bnum>201120</bnum></B430><B450><date>20131009</date><bnum>201341</bnum></B450><B452EP><date>20130726</date></B452EP><B480><date>20131225</date><bnum>201352</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C12Q   1/68        20060101AFI20130225BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>C12Q   1/70        20060101ALI20130225BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>G01N  33/52        20060101ALI20130225BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>G01N  33/574       20060101ALI20130225BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>VERFAHREN ZUR BEWERTUNG DES ORALKARZINOMRISIKOS BEI MENSCHEN</B542><B541>en</B541><B542>METHOD OF EVALUATING ORAL CANCER RISK IN HUMAN</B542><B541>fr</B541><B542>PROCÉDÉ D'ÉVALUATION DU RISQUE D'UN CANCER DE LA BOUCHE CHEZ UN HUMAIN</B542></B540><B560><B561><text>WO-A-2005/081867</text></B561><B561><text>WO-A-2006/020005</text></B561><B562><text>LI Y ET AL: "Salivary transcriptome diagnostics for oral cancer detection" CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 24, 15 December 2004 (2004-12-15), pages 8442-8450, XP002448846 ISSN: 1078-0432</text></B562><B562><text>MAIE JOHN A R ST ET AL: "Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma" ARCHIVES OF OTOLARYNGOLOGY HEAD AND NECK SURGERY, AMERICAN MEDICAL ASSOCIATION, US, vol. 130, no. 8, 1 August 2004 (2004-08-01), pages 929-935, XP002448845 ISSN: 0886-4470</text></B562><B562><text>MAGER DL ET AL: "The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects" JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 3, no. 1, 7 July 2005 (2005-07-07), page 27, XP021009874 ISSN: 1479-5876 cited in the application</text></B562><B562><text>THOMAS SHPITZER ET AL: "A comprehensive salivary analysis for oral cancer diagnosis" JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, BERLIN, DE, vol. 133, no. 9, 4 May 2007 (2007-05-04), pages 613-617, XP019542570 ISSN: 1432-1335</text></B562><B562><text>BAHAR GIDEON ET AL: "Salivary analysis in oral cancer patients - DNA and protein oxidation, reactive nitrogen species, and antioxidant profile" CANCER, vol. 109, no. 1, January 2007 (2007-01), pages 54-59, XP002550244 ISSN: 0008-543X</text></B562><B562><text>PARK NOH JIN ET AL: "RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome." CLINICAL CHEMISTRY DEC 2006, vol. 52, no. 12, December 2006 (2006-12), pages 2303-2304, XP002550245 ISSN: 0009-9147</text></B562><B562><text>MACHADO ROBERTO F ET AL: "Detection of lung cancer by sensor array analyses of exhaled breath" AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 171, no. 11, June 2005 (2005-06), pages 1286-1291, XP002565477 ISSN: 1073-449X</text></B562><B562><text>MAZZONE PETER J: "Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer." JOURNAL OF THORACIC ONCOLOGY : OFFICIAL PUBLICATION OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER JUL 2008, vol. 3, no. 7, July 2008 (2008-07), pages 774-780, XP002565478 ISSN: 1556-1380</text></B562><B562><text>DENG C ET AL: "Investigation of volatile biomarkers in lung cancer blood using solid-phase microextraction and capillary gas chromatography-mass spectrometry" JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES &amp; APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 808, no. 2, 5 September 2004 (2004-09-05), pages 269-277, XP004521137 ISSN: 1570-0232</text></B562><B562><text>HOMANN N ET AL: "Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers" ORAL ONCOLOGY, ELSEVIER SCIENCE, OXFORD, GB, vol. 37, no. 2, 1 February 2001 (2001-02-01), pages 153-158, XP004249009 ISSN: 1368-8375</text></B562><B562><text>CHIAPPIN ET AL: "Saliva specimen: A new laboratory tool for diagnostic and basic investigation" CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 383, no. 1-2, 4 July 2007 (2007-07-04), pages 30-40, XP022142300 ISSN: 0009-8981</text></B562><B562><text>MASHIR A ET AL: "Exhaled breath analysis: The new interface between medicine and engineering" ADVANCED POWDER TECHNOLOGY, VSP, UTRECHT, NL, vol. 20, no. 5, 1 September 2009 (2009-09-01), pages 420-425, XP026743255 ISSN: 0921-8831 [retrieved on 2009-06-14] cited in the application</text></B562><B562><text>CLAUS DIRK ET AL: "Oral malodor, assessed by closed-loop, gas chromatography, and ion-trap technology", HRC JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, vol. 20, no. 2, 1997, pages 94-98, XP55027372, ISSN: 0935-6304</text></B562><B562><text>MANORI J SILVA ET AL: "Detection of phthalate metabolites in human saliva", ARCHIVES OF TOXICOLOGY, SPRINGER-VERLAG, BERLIN, DE, vol. 79, no. 11, 1 November 2005 (2005-11-01), pages 647-652, XP019325439, ISSN: 1432-0738, DOI: 10.1007/S00204-005-0674-4</text></B562><B562><text>JONSSON B A G ET AL: "Determination of cortisol in human saliva using liquid chromatography-electrospray tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES &amp; APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 784, no. 1, 25 January 2003 (2003-01-25), pages 63-68, XP004399418, ISSN: 1570-0232, DOI: 10.1016/S1570-0232(02)00753-5</text></B562><B562><text>LOCHNER A ET AL: "Gas chromatographic-mass spectrometric analysis of volatile constituents in saliva", JOURNAL OF CHROMATOGRAPHY B : BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 378, 1 January 1986 (1986-01-01), pages 267-282, XP026727830, ISSN: 0378-4347, DOI: 10.1016/S0378-4347(00)80724-0 [retrieved on 1986-01-01]</text></B562><B562><text>KOSTELC J G ET AL: "SALIVARY VOLATILES AS INDICATORS OF PERIODONTITIS", JOURNAL OF PERIODONTAL RESEARCH, BLACKWELL MUNKSGAARD, COPENHAGEN, DK, vol. 15, no. 2, 1 March 1980 (1980-03-01), pages 185-192, XP000564963, ISSN: 0022-3484, DOI: 10.1111/J.1600-0765.1980.TB00273.X</text></B562><B562><text>Nadia Fucci ET AL: "Simultaneous detection of some drugs of abuse in saliva samples by SPME technique.", Forensic Science International, vol. 134, no. 1, 1 June 2003 (2003-06-01), pages 40-45, XP55027382, ISSN: 0379-0738</text></B562></B560></B500><B700><B720><B721><snm>CHAUBRON, Franck</snm><adr><str>30 rue du Val de Tourame</str><city>13770 Venelles</city><ctry>FR</ctry></adr></B721></B720><B730><B731><snm>Institut Clinident</snm><iid>101416633</iid><irf>CLD-B-0001 EP1</irf><adr><str>Biopôle Clermont Limagne</str><city>63360 Saint Beauzire</city><ctry>FR</ctry></adr></B731></B730><B740><B741><snm>Barbot, Willy</snm><sfx>et al</sfx><iid>101223365</iid><adr><str>SIMODORO 
Parc Cézanne II, Bât. G 
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