(19)
(11) EP 2 328 401 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.04.2017 Bulletin 2017/16

(45) Mention of the grant of the patent:
08.02.2017 Bulletin 2017/06

(21) Application number: 09810603.2

(22) Date of filing: 27.08.2009
(51) International Patent Classification (IPC): 
C12N 15/82(2006.01)
(86) International application number:
PCT/US2009/055237
(87) International publication number:
WO 2010/025285 (04.03.2010 Gazette 2010/09)

(54)

A DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS

DNA-REPLIKONSYSTEM ZUR ERGIEBIGEN SCHNELLPRODUKTION VON IMPFSTOFFEN UND MONOKLONALEN ANTIKÖRPERTHERAPEUTIKA AUS PFLANZEN

SYSTÈME RÉPLICON POUR PRODUCTION RAPIDE ET À HAUT RENDEMENT DE VACCINS ET DE TRAITEMENTS À BASE D'ANTICORPS MONOCLONAUX CHEZ LES PLANTES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 27.08.2008 US 92318 P

(43) Date of publication of application:
08.06.2011 Bulletin 2011/23

(73) Proprietor: Arizona Board of Regents for and on behalf of Arizona State University
Tempe, AZ 85281 (US)

(72) Inventors:
  • MASON, Hugh, S.
    Phoenix, AZ 85048 (US)
  • HUANG, Zhong
    Shanghai 200025 (CN)
  • CHEN, Qiang
    Chandler, AZ 85225 (US)
  • ARNTZEN, Charles, J.
    Gold Canyon, AZ 85118 (US)
  • YUAN, Shuo
    Tempe, AZ 85284 (US)
  • HJELM, Brooke
    Scottsdale, AZ 85254 (US)

(74) Representative: Potter Clarkson LLP 
The Belgrave Centre Talbot Street
Nottingham NG1 5GG
Nottingham NG1 5GG (GB)


(56) References cited: : 
US-A1- 2003 079 248
US-A1- 2007 214 518
 US-A1- 2004 170 606
US-A1- 2008 070 296
   
  • MOR TSAFRIR S ET AL: "Geminivirus vectors for high-level expression of foreign proteins in plant cells", BIOTECHNOLOGY AND BIOENGINEERING - COMBINATORIAL CHEMISTRY, WILEY, NEW YORK, NY, US, vol. 81, no. 4, 20 February 2003 (2003-02-20), pages 430-437, XP002286327, DOI: 10.1002/BIT.10483
  • HUANG Z ET AL: "Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice", VACCINE, ELSEVIER LTD, GB, vol. 24, no. 14, 24 March 2006 (2006-03-24), pages 2506-2513, XP025151193, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2005.12.024 [retrieved on 2006-03-24]
  • VOINNET O ET AL: "An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus", THE PLANT JOURNAL, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 33, no. 5, 1 March 2003 (2003-03-01), pages 949-956, XP002367694, ISSN: 0960-7412, DOI: 10.1046/J.1365-313X.2003.01676.X
  • ZHONG HUANG ET AL: "A DNA replicon system for rapid high-level production of virus-like particles in plants", BIOTECHNOLOGY AND BIOENGINEERING, vol. 103, no. 4, 1 July 2009 (2009-07-01), pages 706-714, XP55027289, ISSN: 0006-3592, DOI: 10.1002/bit.22299
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).