(19)

(11)

EP 2 328 555 A2

(12)

(88) Date of publication A3: 14.10.2010 (43) Date of publication: 08.06.2011 Bulletin 2011/23 (21) Application number: 09785003.6 (22) Date of filing: 24.08.2009

(51) International Patent Classification (IPC):  A61K 9/14(2006.01) A61K 9/48(2006.01) A61K 31/426(2006.01) A61P 35/00(2006.01) A61K 9/19(2006.01) A61K 31/337(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/GB2009/002068 (87) International publication number: WO 2010/020799 (25.02.2010 Gazette 2010/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 22.08.2008 WO PCT/GB2008/002854 (71) Applicants: Slotervaart Participaties BV 1066 EC Amsterdam (NL) Stichting Het Nederlands Kanker Instituut 1066 CX Amsterdam (NL)	(72) Inventors: BEIJNEN, Jacob, Hendrik NL-1066 EC Amsterdam (NL) SCHELLENS, Johannes, Henricus, Matthias NL-1066 CX Amsterdam (NL) MOES, Johannes NL-1066 EC Amsterdam (NL) NUIJEN, Bastiaan NL-1066 EC Amsterdam (NL) (74) Representative: Wilson, Justin Scott et al Withers & Rogers LLP Goldings House 2 Hays Lane London SE1 2HW London SE1 2HW (GB)