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(11)

EP 2 328 609 A1

(12)

(43) Date of publication: 08.06.2011 Bulletin 2011/23 (21) Application number: 09791877.5 (22) Date of filing: 25.08.2009

(51) International Patent Classification (IPC):  A61K 38/46(2006.01) A61K 38/48(2006.01) A61P 1/18(2006.01) A61K 38/47(2006.01) A61K 9/46(2006.01) (86) International application number: PCT/US2009/054866 (87) International publication number: WO 2010/025126 (04.03.2010 Gazette 2010/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 26.08.2008 US 91773 P (71) Applicant: Cystic Fibrosis Foundation Therapeutics, Inc. Bethesda, MD 20814 (US)	(72) Inventors: PECHENOV, Sergey, Y. Landsdale PA 19446 (US) BASU, Sujit, Kumar Newton MA 02459 (US) MISHRA, Shubhang Southborough MA 01772 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)