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EP 2 328 871 A2

(12)

(88) Date of publication A3: 06.05.2010 (43) Date of publication: 08.06.2011 Bulletin 2011/23 (21) Application number: 09791850.2 (22) Date of filing: 24.08.2009

(51) International Patent Classification (IPC):  C07D 217/04(2006.01) C07D 401/14(2006.01) C07D 403/14(2006.01) C07D 405/14(2006.01) C07D 417/12(2006.01) C07D 487/04(2006.01) A61K 31/47(2006.01) C07D 217/08(2006.01) C07D 403/12(2006.01) C07D 405/12(2006.01) C07D 409/14(2006.01) C07D 473/00(2006.01) C07D 513/04(2006.01) (86) International application number: PCT/US2009/054802 (87) International publication number: WO 2010/027746 (11.03.2010 Gazette 2010/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 25.08.2008 US 91496 P (71) Applicant: IRM LLC Hamilton HM LX (BM)

(72) Inventors: CHENG, Dai San Diego California 92126 (US) HAN, Dong San Diego California 92014 (US) ZHANG, Guobao San Diego California 92130 (US) WAN, Yongqin Irvine California 92606 (US) XIE, Yun Feng San Diego California 92130 (US) JIANG, Jiqing San Diego California 92129 (US) GAO, Wenqi San Diego California 92127 (US) PAN, Shifeng San Diego California 92130 (US) (74) Representative: Kiddle, Simon John et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)