(19)
(11) EP 2 334 297 A1

(12)

(43) Date of publication:
22.06.2011 Bulletin 2011/25

(21) Application number: 08782677.2

(22) Date of filing: 08.08.2008
(51) International Patent Classification (IPC): 
A61K 31/4164(2006.01)
A61P 25/00(2006.01)
 C07D 233/22(2006.01)
(86) International application number:
PCT/US2008/072570
(87) International publication number:
WO 2010/016844 (11.02.2010 Gazette 2010/06)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(71) Applicant: Agean Llc
Louisville, KY 40241 (US)

(72) Inventors:
  • DIGENIS, George, A.
    Louisville KY 40241 (US)
  • CROOKS, Peter
    Nicholasville KY 40356 (US)
  • ALGHANANEEM, Abeer
    Lexington, KY 40513 (US)

(74) Representative: Samson & Partner 
Widenmayerstrasse 5
80538 München
80538 München (DE)

   


(54) LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS