REPRODUCIBLE QUANTIFICATION OF BIOMARKER EXPRESSION

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EP 2 335 221 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	25.05.2016 Bulletin 2016/21

(45)	Mention of the grant of the patent:
	23.03.2016 Bulletin 2016/12

(21)	Application number: 09792559.8

(22)	Date of filing: 15.09.2009

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International Patent Classification (IPC):

G06T 7/00^(2006.01)

G06T 7/40^(2006.01)

(86)	International application number:
	PCT/US2009/056996

(87)	International publication number:
	WO 2010/033508 (25.03.2010 Gazette 2010/12)

(54)	REPRODUCIBLE QUANTIFICATION OF BIOMARKER EXPRESSION REPRODUZIERBARE QUANTIFIZIERUNG EINER BIOMARKEREXPRESSION QUANTIFICATION REPRODUCTIBLE DE L'EXPRESSION DE BIOMARQUEURS

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

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Priority:

16.09.2008 US 97415 P

(43)	Date of publication of application:
	22.06.2011 Bulletin 2011/25

(73)	Proprietor: Novartis AG
	4056 Basel (CH)

(72)	Inventors:
	CHRISTIANSEN, Jason Glastonbury CT 06033 (US) PINARD, Robert Andover MA 01810 (US) GUSTAVSON, Mark Niantic CT 06357 (US) BOURKE, Brian Hamden CT 06517 (US) TEDESCHI, Gregory, R. Cromwell CT 06416 (US) REILLY, Dylan, M. Middletown CT 06457 (US) ZERKOWSKI, Maciej, P. Clinton, CT 06413 (US) WILLIAMS, Christine Nashville, TN 37218 (US) WANG, Dongxiao Orange CT 06477 (US)

(74)	Representative: Nederlandsch Octrooibureau
	P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)

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References cited: :

US-A- 5 134 662

US-A1- 2002 141 049

TEVEROVSKIY M ET AL: "Automated localization and quantification of protein multiplexes via multispectral fluorescence imaging" BIOMEDICAL IMAGING: FROM NANO TO MACRO, 2008. ISBI 2008. 5TH IEEE INTERNATIONAL SYMPOSIUM ON, IEEE, PISCATAWAY, NJ, USA, 14 May 2008 (2008-05-14), pages 300-303, XP031271036 ISBN: 978-1-4244-2002-5
DELL'ANNA R ET AL: "An automated procedure to properly handle digital images in large scale Tissue Microarray experiments" COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 79, no. 3, 1 September 2005 (2005-09-01), pages 197-208, XP025296969 ISSN: 0169-2607 [retrieved on 2005-09-01]
Anil K Jain: "Fundamentals of Digital Image Processing" 1 January 1989 (1989-01-01), Prentice Halls , Englewood Cliffs , XP002562566 , page 418 page 418
GUSTAVSON MARK D ET AL: "Development of an unsupervised pixel-based clustering algorithm for compartmentalization of immunohistochemical expression using Automated QUantitative Analysis" APPLIED IMMUNOHISTOCHEMISTRY, LIPPINCOTT WILLIAMS AND WILKINS, PHILADELPHIA, PA, US, vol. 17, no. 4, 1 July 2009 (2009-07-01), pages 329-337, XP009127702 ISSN: 1062-3345

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