(19)
(11) EP 2 336 187 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
06.07.2016 Bulletin 2016/27

(45) Mention of the grant of the patent:
04.05.2016 Bulletin 2016/18

(21) Application number: 10012392.6

(22) Date of filing: 19.06.2001
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
C12N 5/20(2006.01)
G01N 33/577(2006.01)
A61K 39/395(2006.01)
A61K 51/10(2006.01)
A61P 37/00(2006.01)
A61P 11/06(2006.01)
A61P 15/00(2006.01)
C07K 16/46(2006.01)
G01N 33/53(2006.01)
G01N 33/68(2006.01)
A61K 47/48(2006.01)
A61K 35/14(2006.01)
A61P 31/00(2006.01)
A61P 35/00(2006.01)

(54)

Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations

Zusammensetzungen und Verfahren von monoklonalen oder polyklonalen Antikörpern, die spezifisch für T-Zell Subpopulationen sind

Compositions et méthodes d'anticorps monoclonaux et polyclonaux spécifiques aux sous-populations de lymphocytes T


(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

(30) Priority: 19.06.2000 US 212466 P

(43) Date of publication of application:
22.06.2011 Bulletin 2011/25

(62) Application number of the earlier application in accordance with Art. 76 EPC:
01946572.3 / 1297017

(73) Proprietors:
  • Beth Israel Deaconess Medical Center
    Boston, MA 02215 (US)
  • Dana-Farber Cancer Institute, Inc.
    Boston, MA 02215-5450 (US)
  • The General Hospital Corporation
    Boston, MA 02114 (US)

(72) Inventors:
  • Exley, Mark A.
    Chestnut Hill, MA 02467-1426 (US)
  • Wilson, Samuel B.
    Micanopy, FL 32667 (US)
  • Balk, Steven P.
    Needham, MA 02492 (US)

(74) Representative: Bösl, Raphael Konrad 
Isenbruck Bösl Hörschler LLP Patentanwälte Prinzregentenstraße 68
81675 München
81675 München (DE)


(56) References cited: : 
EP-A- 0 677 533
WO-A-99/34209
EP-A- 1 025 854
   
  • EXLEY MARK ET AL: "CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Valpha24JalphaQ T cell receptor alpha chains.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 188, no. 5, 7 September 1998 (1998-09-07), pages 867-876, XP001074739, ISSN: 0022-1007
  • NICOL A ET AL: "Human invariant Valpha24+ natural killer T cells activated by alpha-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells.", IMMUNOLOGY., vol. 99, no. 2, February 2000 (2000-02), pages 229-234, XP001073724, ISSN: 0019-2805
  • WILSON S BRIAN ET AL: "Development of monoclonal antibodies to Valpha24JalphaQ T cells detects alterations in cell frequency in new-onset type 1 diabetes patients.", DIABETES, vol. 50, no. Supplement 2, June 2001 (2001-06), page A267, XP008004082, 61st Scientific Sessions of the American Diabetes Association;Philadelphia, Pennsylvania, USA; June 22-26, 2001 ISSN: 0012-1797
  • VLIET VAN DER H J J ET AL: "EFFECTS OF ALPHA-GALACTOSYLCERAMIDE (KRN7000), INTERLEUKIN-12 AND INTERLEUKIN-7 ON PHENOTYPE AND CYTOKINE PROFILE OF HUMAN VALPHA24+ VBETA11+ T CELLS", IMMUNOLOGY, BLACKWELL PUBLISHING, OXFORD, GB, vol. 98, no. 4, 1 December 1999 (1999-12-01), pages 557-563, XP008019160, ISSN: 0019-2805, DOI: 10.1046/J.1365-2567.1999.00920.X
  • VAN DER VLIET HANS J J ET AL: "Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells", JOURNAL OF IMMUNOLOGY, vol. 180, no. 11, June 2008 (2008-06), pages 7287-7293, XP002664613, ISSN: 0022-1767
  • MACDONALD H ROBSON: "CD1d-glycolipid tetramers: A new tool to monitor natural killer T cells in health and disease", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 5, 4 September 2000 (2000-09-04), pages F15-F19, ISSN: 0022-1007
  • EXLEY MARK A ET AL: "Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 38, no. 6, June 2008 (2008-06), pages 1756-1766, ISSN: 0014-2980
  • FREDERICKSON SHANA ET AL: "A rationally designed agonist antibody fragment that functionally mimics thrombopoietin", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 103, no. 39, 1 September 2006 (2006-09-01), pages 14307-14312, XP009102615, ISSN: 0027-8424, DOI: 10.1073/PNAS.0602658103
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).