(19)

(11)

EP 2 337 787 A1

(12)

(43) Date of publication: 29.06.2011 Bulletin 2011/26 (21) Application number: 09784045.8 (22) Date of filing: 16.10.2009

(51) International Patent Classification (IPC):  C07K 1/18(2006.01) C12P 21/00(2006.01) C07K 1/30(2006.01) C12N 5/10(2006.01) (86) International application number: PCT/EP2009/063566 (87) International publication number: WO 2010/043701 (22.04.2010 Gazette 2010/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 17.10.2008 US 106324 P 24.10.2008 EP 08167508 (71) Applicant: Percivia LLC. Cambridge, MA 02139 (US)	(72) Inventors: ZARBIS-PAPASTOITSIS, Grigorios Watertown Massachusetts 02139 (US) KUCZEWSKI, Michael, Christopher Newton Massachusetts 02460 (US) BELCHER SCHIRMER, Emily Everett MA 02149 (US) (74) Representative: Sanderson, James L.C. et al Sanderson & Co., 34 East Stockwell Street Colchester Essex CO1 1ST Colchester Essex CO1 1ST (GB)