(19)

(11)

EP 2 340 245 A2

(12)

(88) Date of publication A3: 27.05.2010 (43) Date of publication: 06.07.2011 Bulletin 2011/27 (21) Application number: 09801070.5 (22) Date of filing: 24.07.2009

(51) International Patent Classification (IPC):  C07D 277/36(2006.01) A61K 31/20(2006.01) A61K 31/25(2006.01) A61P 3/10(2006.01) (86) International application number: PCT/US2009/051693 (87) International publication number: WO 2010/011926 (28.01.2010 Gazette 2010/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 25.07.2008 US 83619 P (71) Applicant: Bionevia Pharmaceuticals Inc. Cambridge, MA 02138 (US)

(72) Inventors: KALOFONOS, Isabel Cambridge MA 02138 (US) STAHLY, Patrick, G. West Lafayette IN 47906 (US) MARTIN-DOYLE, William Cambridge MA 02141 (US) KALOFONOS, Dimitris Cambridge MA 02138 (US) STULTS, Jeffrey, S. West Lafayette IN 47906 (US) HOUSTON, Travis, L. Lafayette IN 47909 (US) (74) Representative: Cottrill, Emily Elizabeth Helen  A.A. Thornton & Co. 235 High Holborn London WC1V 7LE London WC1V 7LE (GB)