(19)
(11) EP 2 343 370 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
05.08.2015 Bulletin 2015/32

(45) Mention of the grant of the patent:
24.06.2015 Bulletin 2015/26

(21) Application number: 09815546.8

(22) Date of filing: 04.03.2009
(51) International Patent Classification (IPC): 
A61K 38/43(2006.01)
(86) International application number:
PCT/CN2009/000230
(87) International publication number:
WO 2010/034176 (01.04.2010 Gazette 2010/13)

(54)

A THROMBIN-LIKE ENZYME OF AGKISTRODON ACUTUS

THROMBIN-ÄHNLICHES ENZYM AUS AGKISTRODON ACUTUS

ENZYME DE TYPE THROMBINE D'AGKISTRODON ACUTUS

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA RS

(30) Priority: 27.09.2008 CN 200810223433

(43) Date of publication of application:
13.07.2011 Bulletin 2011/28

(73) Proprietor: Konruns Pharmaceutical Co., Ltd.
Beijing 100085 (CN)

(72) Inventors:
  • SUN, Di
    Beijing 100085 (CN)
  • WANG, Xijuan
    Beijing 100085 (CN)

(74) Representative: Nordic Patent Service A/S 
Højbro Plads 10
1200 Copenhagen K
1200 Copenhagen K (DK)


(56) References cited: : 
WO-A1-2005/017139
CN-A- 1 332 242
CN-A- 101 358 184
 CN-A- 1 332 241
CN-A- 1 502 693
   
  • LIU SI-JIU ET AL: "Purification, characterization, crystallization and preliminary X-ray diffraction of acuthrombin-B, a thrombin-like enzyme from Agkistrodon acutus venom", ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY, MUNKSGAARD PUBLISHERS LTD. COPENHAGEN, DK, vol. 55, no. 6, 1 June 1999 (1999-06-01), pages 1193-1197, XP009163791, ISSN: 0907-4449, DOI: 10.1107/S0907444998014024
  • SUGIHARA H ET AL: "ENZYMOCHEMICAL STUDIES ON SNAKE VENOMS PURIFICATION AND PROPERTIES OF ANTI COAGULANT FACTORS OF ANTI COAGULANT 1 AND 2 IN THE VENOM OF AGKISTRODON-ACUTUS", YAKUGAKU ZASSHI - JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, JAPAN SCIENCE AND TECHNOLOGY INFORMATION AGGREGATOR, ELECTRONIC, JP, vol. 100, no. 8, 1 January 1980 (1980-01-01), pages 811-818, XP009163790, ISSN: 0031-6903
  • DATABASE WPI Week 200676 Thomson Scientific, London, GB; AN 2006-729424 XP002685573, & CN 1 766 100 A (KANGCHEN PHARM DEV CO LTD) 3 May 2006 (2006-05-03)
  • TANI A. ET AL: 'Characterization, primary structure and molecular evolution of anticoagulant protein from Agkistrodon actus venom' TOXICON vol. 40, 31 December 2002, pages 803 - 813, XP008145772
  • CHENG X. ET AL: 'Purification, characterization, and cDNA cloning of a new fibrinogenlytic venom protein, Agkisacutacin, from Agkistrodon acutus venom' BIOCHEM. BIOPHYS. RES. COMMUN. vol. 265, 31 December 1999, pages 530 - 535, XP008145795
  • ZHANG YANYU ET AL: 'Cloning and Bioinformatics Analysis of a Thrombin-like Enzyme Gene from Agkistrodon Acutus' JOURNAL OF EXPERIMENTAL HEMATOLOGY vol. 13, no. 4, 31 December 2005, pages 542 - 547, XP008145774
  • LIANQ NINGSHENG ET AL: 'Molecular Cloning of the New cDNAfor the Thrombin-Like Enzyme form the Venom of Agkistrodon Acutus' JOURNAL OF GUANGXI MEDICAL UNIVERSITY vol. 19, no. 1, 28 February 2002, pages 27 - 30, XP008145793
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).