ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................JBDM Ver 2.0.16 (1th of February 2022) - 2999001/0201608122345671CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120230111W173deBibliographieenBibliographyfrBibliographieEP10184682.2200309262010093020131115enenen414433 P20020927US442301 P20030123US467606 P20030502US477839 P20030612US2023011120230220110720201129201511112015462015042120151111AT20151111BE20151111BG20151111CY20151111CZ20151111EE20160212GR20030926HU20160311PT20151111RO20151111SK20151111TR20230111202302C07K 16/00 20060101AFI20110523BHEP C07K 16/30 20060101ALI20110523BHEP C07K 16/28 20060101ALI20110523BHEP C07K 16/24 20060101ALI20110523BHEP A61K2039/505 20130101 LA20140313BHEP C07K 16/00 20130101 FI20140313BHEP C07K 16/2893 20130101 LI20140313BHEP C07K 16/2896 20130101 LI20140313BHEP C07K 16/32 20130101 LI20140313BHEP C07K2317/72 20130101 LA20140313BHEP C07K2317/732 20130101 LA20140313BHEP C07K2317/734 20130101 LA20140313BHEP C07K2317/94 20130101 LA20140313BHEP C07K2317/34 20130101 LA20140310BHEP A61P 25/00 20180101 LI20200323BHEP A61P 29/00 20180101 LI20200325BHEP A61P 31/00 20180101 LI20200327BHEP A61P 35/00 20180101 LI20200327BHEP A61P 37/00 20180101 LI20200331BHEP deOPTIMIERTE FC VARIANTEN UND METHODEN ZU IHRER HERSTELLUNGenOptimized fc variants and methods for their generationfrVariantes FC optimisées et leurs procédés de générationWO-A2-00/42072SHIELDS R L ET AL: "High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII and FcRn and design of IgG1 variants with improved binding to the Fc gamma R", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 9, 2 March 2001 (2001-03-02) , pages 6591-6604, XP2495886, ISSN: 0021-9258JEFFERIS ROY ET AL: "Interaction sites on human IgG-Fc for FcgammaR: Current models", IMMUNOLOGY LETTERS, vol. 82, no. 1-2, 3 June 2002 (2002-06-03) , pages 57-65, XP002337953, ISSN: 0165-2478CANFIELD S M ET AL: "THE BINDING AFFINITY OF HUMAN IGG FOR ITS HIGH AFFINITY FC RECEPTOR IS DETERMINED BY MULTIPLE AMINO ACIDS IN THE CH2 DOMAIN AND IS MODULATED BY THE HINGE REGION", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 173, no. 6, 1 June 1991 (1991-06-01), pages 1483-1491, XP001181027, ISSN: 0022-1007, DOI: DOI:10.1084/JEM.173.6.1483SONDERMANN P ET AL: "The 3.2-ANG crystal structure of the human IgG1 Fc fragment-FcgammaRIII complex", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 406, no. 6793, 20 July 2000 (2000-07-20), pages 267-273, XP002343993, ISSN: 0028-0836, DOI: DOI:10.1038/35018508IDUSOGIE ESOHE E ET AL: "Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc", JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 164, 1 January 2000 (2000-01-01), pages 4178-4184, XP002965858, ISSN: 0022-176708020666.720425172008112803773056.1155397520030926Lazar, Gregory Alan268 W. Dryden Street, Apt. 114Glendale, CA 91202USChirino, Arthur J.6816 Pueblo VistaCamarillo, CA 91106USDang, Wei472 S. El Molino Ave.1Pasadena, CA 91101USDesjarlais, John Rudolph1030 North Michigan Ave.Pasadena, CA 91104USDoberstein, Stephen Kohn700S. Lake Avenue, Apt 202Pasadena, CA 91106USHayes, Robert J.4 Woodland TerracePaoli, PA 19301USKarki, Sher Busudur2833 Providence WayPomona, CA 91767USVafa, Omid70 Forge Moutain DrivePhoenixville, PA 19460USXencor, Inc.100256631P132758EP2/KLT111 W. Lemon AvenueMonrovia, CA 91016USHGF101272109HGF Limited Saviour House 9 St. SaviourgateYork YO1 8NQGBATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEITLILUMCNLPTROSESISKTR