(19)

(11)

EP 2 347 255 A1

(12)

(43) Date of publication: 27.07.2011 Bulletin 2011/30 (21) Application number: 09821264.0 (22) Date of filing: 15.10.2009

(51) International Patent Classification (IPC):  G01N 33/48(2006.01) (86) International application number: PCT/US2009/060871 (87) International publication number: WO 2010/045475 (22.04.2010 Gazette 2010/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 17.10.2008 US 106405 P (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: LIAO, Guochun Belmont, California (US) ZHENG, Ming Mountain View, California (US) (74) Representative: Lord, Michael  Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES London EC2A 2ES (GB)