ISOXAZOLE/ISOXAZOLINE/COMBRETASTATIN LINKED DIHYDROQUINAZOLINONE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF

Description

FIELD OF THE INVENTION

[0001] The present invention relates to Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as anticancer agents. Particularly, the present invention relates to Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general formula A.

Where in G =

or

or

R₂ = 2-OCH₃ and R₃ = 6-OCH₃ or 6-H
X = H, Cl, CH₃, OCH₃

[0002] More particularly the present invention relates to 2-[4-(5-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy Phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one,2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one;2-(4-(5-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxy-phenyl) isoxazol-3-yl)phenoxy)pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one, 2-(4-(5-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxy phenyl) isoxazol-5-yl)phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one,(Z)-2-(4-(5-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one with aliphatic chain length variations useful as anticancer(antitumour) agents. The structural formulae of these isoxazole/isoxazoline/combretastatin-dihydroquinazolinone hybrids is given below.

n = 1-9

n = 1-9

n = 1-9

n = 1-9

n = 1-9

BACKGROUND OF THE INVENTION

[0003] Inhibition of tubulin polymerization is the target of many antitumoural agents known as antimitotic agents or spindle poisons colchicines, podophyllo-toxins and combretastatins are representative examples of compounds that inhibit microtubule assembly by binding to tubulin. 2-Aryl- and 2-styrylquinazolin-4(3H)-ones(SQZ) and 2,3-dihydro-2-aryl-4-quinazolinones (DHPQ) are compounds that possess this common structural feature for an effective interaction with tubulin. The antitumor activities of 2,3-dihydro-2-aryl-4-quinazolinones (DHPQZ) were reported around1970 (Yale HL, Kalkstein M. Substituted 2,3-dihydro-4(1H)-quinazolinones, a new class of inhibitorsof cell multiplication. J Med Chem 1967 10, 334-336, Neil, G. L.; Li, L. H.; Buskirk, H. H.; Moxlcy, T. E. Cancer Chemother. 1972, 56, 163-173. and Hamel, E.; Lin, C. M.; Plowman, J.; Wang, H. K.; Lee, K. H.;Paull, K. D. Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. Biochem. Pharmacol. 1996, 51, 53-59). A more recent reevaluation of this type of compound by NCI against human tumor cell lines reconfirmed that, like colchicine, they are effective inhibitors of tubulin polymerization. Many isoxazole, isoxazoline type moieties related to combretastain A-4 showed potential biological properties particularly anticancer activity (Simoni, D.; Grisolia, G.; Giannini, G.; Roberti, M.;Rondanin, R.; Piccagli, L.; Baruchello, R.; Rossi, M.;Romagnoli, R.; Invidiata, F. P.; Grimaudo, S.; Jung, M.K.; Hamel, E.; Gebbia, N.; Crosta, L.; Abbadessa, V.; DiCristina,A.;Dusonchet, L.; Meli, M.; Tolomeo, M. J. Med. Chem. 2005, 48, 723, Julia Kaffy, a Rene'e Pontikis,a,* Danie'le Carrez,b Alain Croisy, Claude Monnereta and Jean-Claude Florent. Bioorg. Med. Chem. 2006, 14, 4067-4077, Gian Ceasure Tron, Tracy Pirali, Giovanni sorba, Francesca pagliai, Sara Buasacca and Armado A.Genazzani. J. Med. Chem. 2006, 49, 3033-3044. and Tracey Pirali, Sara buasacca, Lorena Beltrami, Daniela Imovilli, Francesca Paliai,Gianluca Migilio, Alberto Massrotti, Luisella Verotta, Gian Cesare Tron, Givanni Sorba, and Armado A. Genazzani. J. Med. Chem. 2006, 49, 5372-5376). Some of the heterocyclic bridged Combretastains showed an attractive profile cytotoxicity and were able to induce apoptosis at lower concentrations.

OBJECTIVES OF THE INVENTION

[0004] The main objective of the present invention is to provide novel isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids useful as antitumour agents.

[0005] Yet another object of this invention is to provide a process for the preparation of novel isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids

SUMMARY OF THE INVENTION

[0006] Accordingly the present invention provides a novel isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general

formulae A
Where in G =

or

or

R₂ = 2-OCH₃ and R₃ = 6-OCH₃ or 6-H
X = H, Cl, CH₃, OCH₃

[0007] In an embodiment of the present invention the novel isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of formulae A is represented by the compounds of general formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-ito37a-i and 39a-i to 42a-i, 43a-i to 46a-i.





n = 1-9

n = 1-9

n = 1-9

[0008] In yet another embodiment the isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids are represented by the group of the following compounds:

2-[3-Methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3a)

2-[3-Methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3b)

2-[3-Methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3c)

2-[3-Methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3d)

2-[3-Methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3e)

2-[3-Methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3f)

2-[3-Methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3g)

2-[3-Methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3h)

2-[3-Methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3i)

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4a)

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4b)

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4c)

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4d)

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4e)

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4f)

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4g)

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4h)

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4i)

6-Methyl 2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5a)

6-Methyl 2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5b)

6-Methyl 2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5c)

6-Methyl 2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5d)

6-Methyl 2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-hexyloxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5e)

6-Methyl 2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5f)

6-Methyl 2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5g)

6-Methyl 2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5h)

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5i)

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6a)

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6b)

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6c)

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6d)

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6e)

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6f)

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6g)

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6h)

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6i)

2-[4-(2-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7a)

2-[4-(3-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7b)

2-[4-(4-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7c)

2-[4-(5-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7d)

2-[4-(6-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7e)

2-[4-(7-12,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7f)

2-[4-(8-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7g)

2-[4-(9-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7h)

2-[4-(10-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro 1H-quinazolin-4-one(7i)

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8a)

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8b)

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8c)

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro 1H-quinazolin-4-one(8d)

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8e)

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8f)

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxyl-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8g)

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8h)

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8i)

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9a)

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9b)

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9c)

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9d)

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9e)

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9f)

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9g)

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9h)

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10c)

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10h)

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10i)

2-[3-Methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12a)

2-[3-Methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12b)

2-[3-Methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12c)

2-[3-Methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12d)

2-[3-Methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5 dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12e)

2-[3-Methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12f)

2-[3-Methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12g)

2-[3-Methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12h)

2-[3-Methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-dedyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12i)

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13a)

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13b)

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13c)

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13d)

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13e)

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13f)

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13g)

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13h)

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13i)

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14a)

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14b)

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14c)

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14d)

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14e)

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14f)

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14g)

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14h)

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14i)

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15a)

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15b)

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15c)

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15d)

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H quinazolin-4-one(15e)

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15f)

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15g)

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15h)

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15i)

2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16a)

2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16b)

2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16c)

2-[4-(5-{ 2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16d)

2-[4-(6-{ 2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16e)

2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16f)

2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16g)

2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16h)

2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydroisoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16i)

6-Chloro-2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17a)

6-Chloro-2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17b)

6-Chloro-2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17c)

6-Chloro-2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17d)

6-Chloro-2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17e)

6-Chloro-2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17f)

6-Chloro-2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17g)

6-Chloro-2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17h)

6-Chloro-2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17i)

6-Methyl-2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18a)

6-Methyl-2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18b)

6-Methyl-2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18c)

6-Methyl-2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18d)

6-Methyl-2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18e)

6-Methyl-2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18f)

6-Methyl-2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18g)

6-Methyl-2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18h)

6-Methyl-2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19c)

6-Methoxy-2-[4-(5-{ 2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19h)

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19i)

2-(3-methoxy-4-(2-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21a)

2-(3-methoxy-4-(3-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)propoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21b)

2-(3-methoxy-4-(4-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21c)

2-(3-methoxy-4-(5-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21d)

2-(3-methoxy-4-(6-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)hexyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21e)

2-(3-methoxy-4-(7-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)heptyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21f)

2-(3-methoxy-4-(8-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21g)

2-(3-methoxy-4-(9-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21h)

2-(3-methoxy-4-(10-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21i)

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22a)

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22b)

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22c)

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22d)

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22e)

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22f)

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22g)

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22h)

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22i)

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23a)

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23b)

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23c)

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23d)

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23e)

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23f)

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23g)

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23h)

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23i)

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24a)

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24b)

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24c)

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24d)

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24e)

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24f)

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24g)

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24h)

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24i)

2-(4-(2-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) ethoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25a)

2-(4-(3-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) propoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25b)

2-(4-(4-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) butoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25c)

2-(4-(5-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25d)

2-(4-(6-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) hexyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25e)

2-(4-(7-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) heptyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25f)

2-(4-(8-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) octyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25g)

2-(4-(7-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) heptyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25f)

2-(4-(8-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) octyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25g)

2-(4-(9-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) nonyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25h)

2-(4-(10-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) decyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25i)

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26a)

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1 H-quinazolin-4-one(26b)

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26c)

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26d)

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1 H-quinazolin-4-one(26e)

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26f)

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26g)

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26h)

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26i)

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27a)

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27b)

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27c)

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27d)

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27e)

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27f)

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27g)

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27h)

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28c)

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28h)

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28i)

2-(3-methoxy-4-(2-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30a)

2-(3-methoxy-4-(3-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)propoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30b)

2-(3-methoxy-4-(4-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30c)

2-(3-methoxy-4-(5-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30d)

2-(3-methoxy-4-(6-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)hexyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30e)

2-(3-methoxy-4-(7-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)heptyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30f)

2-(3-methoxy-4-(8-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30g)

2-(3-methoxy-4-(9-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30h)

2-(3-methoxy-4-(10-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl) phenoxy)decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30i)

6-Chloro-2-[3-methoxy-4-(2-12-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31a)

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31b)

6-Chloro-2-[3-methoxy-4-(4-12-methoxy-5-[3-(,3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(31c)

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31d)

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31e)

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(31f)

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31g)

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31h)

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(31i)

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32a)

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-qunazolin-4-one(32b)

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32c)

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32d)

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32e)

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32f)

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32g)

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32h)

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32i)

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33a)

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33b)

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33c)

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33d)

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33e)

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33f)

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33g)

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33h)

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33i)

2-(4-(2-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) ethoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34a)

2-(4-(3-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) propoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34b)

2-(4-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) butoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34c)

2-(4-(5-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34d)

2-(4-(6-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) hexyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34e)

2-(4-(7-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) heptyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34f)

2-(4-(8-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) octyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34g)

2-(4-(9-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) nonyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34h)

2-(4-(10-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) decyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34i)

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35a)

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35b)

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35c)

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5 -yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35d)

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35e)

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35f)

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35g)

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35h)

6-Chloro-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35i)

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36a)

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36b)

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36c)

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36d)

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36e)

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36f)

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36g)

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36h)

6-Methyl-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37c)

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37h)

6-Methoxy-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37i)

(Z)-2-(3-methoxy-4-(2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39a)

(Z)-2-(3-methoxy-4-(3-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) propoxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one(39b)

(Z)-2-(3-methoxy-4-(4-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39c)

(Z)-2-(3-methoxy-4-(5-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) pentyloxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one(39d)

(Z)-2-(3-methoxy-4-(6-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) hexyloxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one(39e)

(Z)-2-(3-methoxy-4-(7-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) heptyloxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one(39f)

(Z)-2-(3-methoxy-4-(8-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39g)

(Z)-2-(3-methoxy-4-(9-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39h)

(Z)-2-(3-methoxy-4-(10-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39i)

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40a)

6-Chloro-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40b)

6-Chloro-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40c)

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40d)

6-Chloro-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40e)

6-Chloro-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40f)

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40g)

6-Chloro-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40h)

6-Chloro-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40i)

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41a)

6-Methyl-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41b)

6-Methyl-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41c)

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl] -phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41d)

6-Methyl-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41e)

6-Methyl-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41f)

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41g)

6-Methyl-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41h)

6-Methyl-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41i)

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42a)

6-Methoxy-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42b)

6-Methoxy-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42c)

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42d)

6-Methoxy-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42e)

6-Methoxy-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42f)

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42g)

6-Methoxy-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42h)

6-Methoxy-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42i)

(Z)-2-(4-(2-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) ethoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43a)

(Z)-2-(4-(3-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) propoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43b)

(Z)-2-(4-(4-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) butoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43c)

(Z)-2-(4-(5-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) pentyoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43d)

(Z)-2-(4-(6-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) hexyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43e)

(Z)-2-(4-(7-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) heptyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43f)

(Z)-2-(4-(8-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) octyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43g)

(Z)-2-(4-(9-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) nonyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43h)

(Z)-2-(4-(10-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) decyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43i)

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44a)

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44b)

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44c)

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44d)

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44e)

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44f)

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44g)

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44h)

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44i)

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45a)

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45b)

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45c)

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45d)

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45e)

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45f)

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45g)

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45h)

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46c)

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46h)

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46i)

[0009] The present invention further provides a process for preparation of novel isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to 37a-i and 39a-i to 42a-i, 43a-i to 46a-i.
which comprises
Reacting 2-[4-(n-Bromo-alkyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one of formula 2
with the compounds of formulae 1a, 1b, 11a, 11b, 20a, 20b, 29a, 29b, 38a,38b respectively in an aprotic water miscible organic solvent, in the presence of anhydrous mild inorganic base, under room temperature for a period of about 48 hrs, followed by the removal of inorganic base by filtration and evaporating the organic solvent to obtain the resultant crude product and purifying it by column chromatography to obtain the desired products of formulae 3a-i to 6a-i, 7a-i to 10a-i,
12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to 37a-i and 39a-i to 42a-i, 43a-i to 46a-i respectively.

DETAILED DESCRIPTION OF THE INVENTION

[0010] The precursor dihydroquinazolinone of formula 2, has been prepared using literature method (Mann-Jen Hour,† Li-Jiau Huang,† Sheng-Chu Kuo,*,† Yi Xia,‡ Kenneth Bastow,§ Yuka Nakanishi,§Ernest Hamel,| and Kuo-Hsiung Lee*,‡J. Med. Chem. 2000, 43, 4479-4487). The precursors isoxazoles, isoxazolines and combretastatins of formulae 1(a&b), 11(a&b), 20(a&b), 29(a&b) and 38(a&b) have been prepared using literature methods(Julia kaffy, Renee Pontikis, Daniele Carrez, Alain Croisy, Claude Monneret and Jean-Claude Florent. Bioorg. Med. Chem. 2006, 14, 4067-4077, Simoni, D.; Grisolia, G.; Giannini, G.; Roberti, M.;Rondanin, R.; Piccagli, L.; Baruchello, R.; Rossi, M.;Romagnoli, R.; Invidiata, F. P.; Grimaudo, S.; Jung, M.K.; Hamel, E.; Gebbia, N.; Crosta, L.; Abbadessa, V.; DiCristina,A.;Dusonchet, L.; Meli, M.; Tolomeo, M. J. Med. Chem. 2005, 48, 723)

[0011] These new analogues of isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids have shown promising anticancer activity in various cell lines. The molecules synthesized are of immense biological significance. This resulted in design and synthesis of new congeners as illustrated in schemes 1-5 which comprise:

[0012] The ether linkage between dihydroquinazolinone of formula 2 and isoxazole/isoxazoline/combretastatins of formulae 1(a&b), 11(a&b), 20(a&b), 29(a&b) and 38(a&b)

1.Stirring the reaction mixtures at a temperature of 35 °c for 30 h.

2.Synthesis of isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids

3.Purification by column chromatography using different solvents like ethyl acetate, hexane, dichloromethane and methanol.

OTBDMS=Tertiary Butyl Dimethyl Silyloxy

OTBDMS=Tertiary Butyl Dimethyl Silyloxy

OTBDMS=Tertiary Butyl Dimethyl Silyloxy

OTBDMS=Tertiary Butyl Dimethyl Silyloxy

OTBDMS=Tertiary Butyl Dimethyl Silyloxy

[0013] The following examples are given by way of illustration and therefore should not be construed to the present limit of the scope of invention.

Example 1

2-[3-Methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3d)

[0014] 2-Methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenol(1a) (359.37 mg, 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.31 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (3d) (557mg, 80% yield).

[0015] ¹H NMR (CDCl₃): □ □ □1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.69-3.82 (dd, 1H, J = 10.7 Hz, J= 16.4 Hz), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 5.63-5.73 (t, 1H, J = 10.1 Hz, J = 9.2 Hz), 5.77 (s, 1H), 6.57-6.61 (d, 1H, J = 7.9 Hz), 6.63 (s, 1H) 6.76-6.79 (d, 1H, J = 8.1 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J = 7.5 Hz J=15.2Hz), 7.82-7.87 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:698.75 (M+H)⁺.

Example 2

2-[4-(5-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7d)

[0016] 2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenol (1b) (389.15 mg, 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.31 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (7d) (583 mg, 80% yield).

[0017] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.69-3.82 (dd, 1H, J = 10.7 Hz, J= 16.4 Hz), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 5.63-5.73 (t, 1H, J= 10.1 Hz, J= 9.2 Hz), 5.77 (s, 1H), 6.62 (s, 2H), 6.82-6.85 (d, 1H, J= 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:728.78M+H)⁺.

Example 3

2-[3-Methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12d)

[0018] 2-Methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]phenol(11a) (359.37 mg, 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.31 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (12d) (546mg, 80% yield).

[0019] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.69-3.82 (dd, 1H, J = 10.7 Hz, J = 16.4 Hz), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 5.63-5.73 (t, 1H, J = 10.1 Hz, J= 9.2 Hz), 5.77 (s, 1H), 6.57-6.61 (d, 1H, J = 7.9 Hz), 6.63 (s, 1H) 6.76-6.79 (d, 1H, J = 8.1 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.87 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:698.75 (M+H)⁺.

Example 4

2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16d)

[0020] 2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenol (11b)(389.40 mg, 1.0 mmol ) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.31 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (16d) (570mg, 80% yield).

[0021] ¹H NMR (CDCl₃): □ □ □1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.69-3.82 (dd, 1H, J = 10.7 Hz, J= 16.4 Hz), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 5.63-5.73 (t, 1H, J = 10.1 Hz, J = 9.2 Hz), 5.77 (s, 1H), 6.62 (s, 2H), 6.82-6.85 (d, 1H, J = 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:728.80 (M+H)⁺.

Example 5

2-(3-methoxy-4-(5-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21d)

[0022] 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)phenol (20a) (357.36 mg 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (21d) (546mg, 80% yield).

[0023] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J= 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.57-6.61 (d, 1H, J = 7.9 Hz), 6.63 (s, 1H), 6.67 (s, 1H), 6.76-6.79 (d, 1H, J = 8.1 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.87 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:696.76(M+H)⁺.

Example 6

2-(4-(5-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (25d)

[0024] 2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)phenol (20b) (387.38 mg,1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (25d) (546mg, 80% yield).

[0025] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J= 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.62 (s, 2H), 6.67 (s, 1H) 6.82-6.85 (d, 1H, J = 7.7 Hz), 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:726.78(M+H)⁺.

Example 7

2-(3-methoxy-4-(5-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30d)

[0026] 2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol (29a) (357.36 mg 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (30d) (546mg, 80% yield).

[0027] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J= 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.57-6.61 (d, 1H, J = 7.9 Hz), 6.63 (s, 1H), 6.67 (s, 1H), 6.76-6.79 (d, 1H, J = 8.1 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz) 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.87 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:696.76(M+H)⁺.

Example 8

2-(4-(5-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34d)

[0028] 2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)phenol (29b) (387.38 mg 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (34d) (546mg, 80% yield).

[0029] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.62 (s, 2H), 6.67 (s, 1H) 6.82-6.85 (d, 1H, J = 7.7 Hz), 6.88 (s, 2H), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.74 Hz J = 7.55 Hz) FABMS:726.78(M+H)⁺.

Example 9

(Z)-2-(3-methoxy-4-(5-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)pentyloxy) phenyl)-2,3-dihydroquinazolin-4(1H)-one(39d)

[0030] (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenol (38a) (316.35 mg 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °C for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (39d) (546mg, 80% yield).

[0031] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.2 Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.39 (d, 2H, J = 4.4 Hz), 6.47 (s, 2H) 6.73 (d, 1H, J = 2.2 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz), 6.89 (d, 1H, J = 2.2 Hz), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.55 Hz J = 7.74 Hz) FABMS:655.75M+H)⁺.

Example 10

(Z)-2-(4-(5-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)pentyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43d)

[0032] (Z)-2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenol (38b) (346.37.36 mg 1.0 mmol) in DMF (20 mL) was added anhydrous potassium carbonate (690 mg, 5.0 mmol) and 2-[4-(5-Bromo-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one (2d) (419.29 mg, 1.0 mmol). The reaction mixture was stirred at a temperature of 30 °c for 30 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. Then to this ice is added and extracted with ethyl acetate. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate: hexane (6:4) as a solvent system to obtain the pure product (43d) (546mg, 80% yield).

[0033] ¹H NMR (CDCl₃): □□□1.70-1.80 (m, 2H), 1.89-2.02 (m, 4H), 3.84 (s, 6H), 3.87 (s, 3H), 3.92 (s, 3H), 3.89 (s, 6H), 3.94 (s, 3H), 4.02-4.08 (t, 2H, J = 5.2 Hz), 4.10-4.16 (t, 2H, J = 6.4 Hz), 4.39-4.42 (bs, NH), 6.04 (s, 1H), 6.47 (s, 2H), 6.70 (s, 2H), 6.73 (d, 1H, J = 2.2 Hz), 6.82-6.85 (d, 1H, J = 7.7 Hz), 6.89 (d, 1H, J = 2.2 Hz), 6.90 (s, 1H), 6.94-6.97 (d, 1H, J = 7.7 Hz), 7.18-7.21 (m, 2H), 7.22-7.29 (dd, 1H, J=7.5 Hz J=15.2Hz), 7.82-7.92 (dd, 1H, J = 7.55 Hz J = 7.74 Hz): FABMS:685.77M+H)⁺.

[0034] Biological Activity: some of in vitro biological activity studies were carried out at the National Cancer Institute, Maryland, USA.

In vitro Cytotoxicity

[0035] The isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrid (7d) has been tested against forty nine human tumour cell lines derived from nine cancer types (leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer) as per NCI protocol. For each compound, dose response curves for individual cell lines have been measured at a minimum of five concentrations at 10 fold dilutions. A protocol of 48 h continuous drug exposure has been used, and a sulforhodamine B (SRB) protein assay was used to estimate cell viability or growth. The concentration for 50% cell growth inhibition (GI₅₀), total cell growth inhibition (TGI, 0% growth) and 50% cell death (LC₅₀, 50% growth) compared with the control has been calculated (Table-1). Compound 7d has been evaluated for their in vitro cytotoxicity in forty nine cell lines from nine human cancer types of lung (Hop-62, NCI-H226, NCI-H522), leukemia (K-562, SR), colon (HCT-116, HCT-15, HCC-2998), CNS (SF-539), melanoma (SK-MEL-5, MDA-MB-435, UACC-62, M14), ovarian (IGROV1), renal (A498), prostate (PC3) breast (BT-549, HS578T) origin. The results are expressed as percent of cell growth determined relative to that of untreated control cells (Table 2). The representative compound 7d has shown significant cytotoxicity against some cancer cell lines.

Table-1. Log₁₀ GI₅₀ (concentration in mol/L causing 50% growth inhibition) values for quinazolinone-PBD hybrid(7d)

	Log10 GI50	Log10 LC50
Leukemia	-6.17	-4.15
Non-small-celllung	-4.97	-4.00
Colon	-5.17	-4.00
CNS	-4.66	-4.00
Melanoma	-5.69	-4.00
Ovarian	-5.20	-4.00
Renal	-4.72	-4.00
Prostate	-5.39	-4.00
Breast	-5.82	-4.00

Each cancer type represents the average of six to eight different cancer cell lines.

[0036] The compound 7d exhibits a wide spectrum of activity against forty nine cell lines in nine cell panels, with GI₅₀ value of <40 µm. In the non-small cell lung cancer panel, the growth of EKVX, NCI-H23 cell lines were affected by compound 7d with GI₅₀ values as 0.36 and 0.38 µM respectively. The GI₅₀ values of compound 7d against colon cancer HCC-2998, HCT-116 cell lines are 0.06 and 0.26 µm respectively. The GI₅₀ values for compound 7d against leukemia CCRF-CEM, K-562, MOLT-4 and RPMI-8226 cell lines are 0.62, 0.37, 0.68 and 0.06 µm respectively. The GI₅₀ values for compound 7d against melanoma SK-MEL-5, UACC-257, MDA-MB-435, and UACC-62 cell lines are 0.18, 0.29, 0.60 and 0.99 µm respectively. The GI₅₀ values for compound 7d against ovarian IGROV1 and OVCAR-4 cell lines are 0.32 and 0.49 µM. The GI₅₀ values for compound 7d against renal ACHN cell line is 0.95 µm The GI₅₀ values for compound 7d against prostate PC-3 cell line is 0.74 µm. The GI₅₀ values for compound 7d against breast MCF7, T-47D, MDA-MB-468 cell lines are 0.45, 0.30, 0.08µm respectively.

[0037] Compound 7d exhibits activity against forty nine cell lines in nine cancer cell panels with GI₅₀ values of < 40µm. in vitro cytotoxicity of compound 7d in selected cancer cell lines has been illustrated in Table 2. The average GI₅₀ values for each cancer panel of compounds 7d have been illustrated in Table2.

Table 2. In vitro cytotoxicity of compounds 7d in forty nine cancer cell lines

Cancer panel/cell line	GI50 (µm) 7d	Cancer panel/cell line	GI50 (µm) 7d
Leukemia		Ovarian
CCRF-CEM	0.62	IGROV1	0.32
HL-60(TB)	12.2	OVCAR-3	12.4
K-562	0.37	OVCAR-4	0.49
MOLT-4	0.68	OVCAR-5	31.7
RPMI-8226	0.06	OVCAR-8	25.7
		SK-OV-3	38.5
		NCI/ADRRES	10.6
Non-small		Renal
cell lung		786-0	31.8
A549/ATCC	15.7	A498	19.3
EKVX	0.36	ACHN	0.95
HOP-92	15.8	CAKI-1	18.0
NCI-H23	0.38	SN12C	39.1
NCI-H460	15.1	UO-31	21.4
NCI-H522	27.4
Colon		Prostate
HCC-2998	0.06	PC-3	0.74
HCT-116	0.26	DU-145	22.4
HCT-15	15.9
KM12	10.4
SW-620	21.0
CNS		Breast
SF-268	20.2	MCF7	0.45
SF-295	16.4	MDA-MB-231/ATCC	14.7
SF-539	21.2	HS 578T	15.0
SNB-19	16.6	T-47D	0.30
SNB-75	34.2	MDA-MB-468	0.08
U251	25.2
Melanoma		Melanoma
LOX IMVI	19.5	SK-MEL-28	3.24
M14	19.8	SK-MEL-5	0.18
		UACC-257	0.29
		UACC-62	0.99
		MDA-MB-435	0.60

[0038] The mean graph mid point values of log₁₀ TGI and log₁₀ LC₅₀ as well as log₁₀ GI₅₀ for 7d is listed in Table-3. As demonstrated by mean graph pattern, compounds 7d exhibit an interesting profile of activity and selectivity for various cell lines. The mean graph mid points of log₁₀ TGI and log₁₀ LC₅₀ have shown similar pattern to the log₁₀ GI₅₀ mean graph mid points.

Table-3. log₁₀ GI₅₀, log₁₀ TGI and log₁₀ LC₅₀ mean graphs midpoints(MG_MID) of in vitro cytotoxicity data for the compound 7d.against human tumour cell lines.

Compound	Log10 GI50	Log10 TGI	Log10 LC50
7d	-5.28	-4.18	-4.02

SIGNIFICANCE OF THE WORK CARRIED OUT

[0039] The novel dihydroquinazolinone-isoxazole/isoxazoline/combretastatin hybrids that have been synthesized exhibited significant cytotoxic activity against forty nine human tumour cell lines.

ADVANTAGES OF THE INVENTION

[0040] 

1. The present invention provides a new dihydroquinazolinone-isoxazole/ isoxazoline/combretastatin hybrids useful as antitumour agents.

2. It also provides a process for the preparation of novel dihydroquinazolinone-isoxazole/isoxazoline/combretastatin hybrids.

Claims

1. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general formulae A

Where in G =

R₂ = 2-OCH₃ and R₃ = 6-OCH₃ or 6-H
X = H, Cl, CH₃, OCH₃

2. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as claimed in claim1 wherein the isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of formula A is represented by the compounds of general formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-i to 37a-i and 39a-i to 42a-i, 43a-i to 46a-i

n = 1-9

n = 1-9

n = 1-9

n = 1-9

where n = 1-9

3. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as claimed in claim 1 is represented by the group of the following compounds:

2-[3-Methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro -isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3a);

2-[3-Methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3b);

2-[3-Methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3c);

2-[3-Methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3d);

2-[3-Methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3e);

2-[3-Methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3f);

2-[3-Methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3g);

2-[3-Methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3h);

2-[3-Methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(3i);

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4a);

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4b);

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4c);

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4d);

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4e);

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4f);

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4g);

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4h);

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4i);

6-Methyl 2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5a);

6-Methyl 2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5b);

6-Methyl 2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5c);

6-Methyl 2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5d);

6-Methyl 2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-hexyloxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5e);

6-Methyl 2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5f);

6-Methyl 2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5g);

6-Methyl 2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(5i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(6i);

2-[4-(2-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7a);

2-[4-(3-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7b);

2-[4-(4-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7c);

2-[4-(5-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7d);

2-[4-(6-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7e);

2-[4-(7-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7f);

2-[4-(8-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7g);

2-[4-(9-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(7h);

2-[4-(10-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro 1H-quinazolin-4-one(7i);

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8a);

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8b);

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8c);

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro 1H-quinazolin-4-one(8d);

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8e);

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8f);

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8g);

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8h);

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(8i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(9i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(10i);

2-[3-Methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12a);

2-[3-Methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12b);

2-[3-Methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12c);

2-[3-Methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12d);

2-[3-Methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5 dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12e);

2-[3-Methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12i);

2-[3-Methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12g);

2-[3-Methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12h);

2-[3-Methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-dedyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(12i);

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13a);

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13b);

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13c);

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13d);

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13e);

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13f);

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13g);

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13h);

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(13i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(14i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H quinazolin-4-one(15e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(15i);

2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16a);

2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-l H-quinazolin-4-one(16b);

2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)- 3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16c);

2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16d);

2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16e);

2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16f);

2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16g);

2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16h);

2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(16i);

6-Chloro-2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17a);

6-Chloro-2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17b);

6-Chloro-2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(17c);

6-Chloro-2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17d);

6-Chloro-2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17e);

6-Chloro-2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17f);

6-Chloro-2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17g);

6-Chloro-2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17h);

6-Chloro-2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(17i);

6-Methyl-2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18a);

6-Methyl-2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18b);

6-Methyl-2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(18c);

6-Methyl-2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18d);

6-Methyl-2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18e);

6-Methyl-2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18f);

6-Methyl-2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18g);

6-Methyl-2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18h);

6-Methyl-2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(18i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(19c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl] 2,3-dihydro-1H-quinazolin-4-one(19i);

2-(3-methoxy-4-(2-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl) phenoxy)ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21a);

2-(3-methoxy-4-(3-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)propoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21b);

2-(3-methoxy-4-(4-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21c);

2-(3-methoxy-4-(5-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21d);

2-(3-methoxy-4-(6-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)hexyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21e);

2-(3-methoxy-4-(7-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)heptyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21f);

2-(3-methoxy-4-(8-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21g);

2-(3-methoxy-4-(9-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21h);

2-(3-methoxy-4-(10-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl) isoxazol-3-yl)phenoxy)decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(21i);

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22a);

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22b);

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22c);

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22d);

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22e);

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22f);

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22g);

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22h);

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(22i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy)-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1-quinazolin-4-one(23h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(23i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxyl-butyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(24i);

2-(4-(2-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) ethoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25a);

2-(4-(3-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)propoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25b);

2-(4-(4-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)butoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25c);

2-(4-(5-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25d);

2-(4-(6-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)hexyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25e);

2-(4-(7-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)heptyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25f);

2-(4-(8-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)octyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25g);

2-(4-(9-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy)nonyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25h);

2-(4-(10-(2,6-dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl) phenoxy) decyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(25i);

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26a);

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26b);

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26c);

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26d);

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26e);

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26f);

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26g);

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26h);

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(26i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(27i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(28h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1 H-quinazolin-4-one(28i);

2-(3-methoxy-4-(2-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30a);

2-(3-methoxy-4-(3-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)propoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30b);

2-(3-methoxy-4-(4-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30c);

2-(3-methoxy-4-(5-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30d);

2-(3-methoxy-4-(6-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)hexyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30e);

2-(3-methoxy-4-(7-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)heptyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30f);

2-(3-methoxy-4-(8-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30g);

2-(3-methoxy-4-(9-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30h);

2-(3-methoxy-4-(10-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl) isoxazol-5-yl)phenoxy)decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(30i);

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31a);

6-Chloro-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31b);

6-Chloro-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31c);

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31d);

6-Chloro-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31e);

6-Chloro-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(31f);

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31g);

6-Chloro-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(31h);

6-Chloro-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(31i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(32h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(32i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(33h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]--2,3-dihydro-1H-quinazolin-4-one(33i);

2-(4-(2-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)ethoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34a);

2-(4-(3-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) propoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34b);

2-(4-(4-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)butoxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34c);

2-(4-(5-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy) pentyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34d);

2-(4-(6-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)hexyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34e);

2-(4-(7-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)heptyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34f);

2-(4-(8-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)octyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34g);

2-(4-(9-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)nonyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34h);

2-(4-(10-(2,6-dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl) phenoxy)decyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(34i);

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35a);

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35b);

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35c);

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5 -yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35d);

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35e);

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35f);

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35g);

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35h);

6-Chloro-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(35i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36h);

6-Methyl-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(36i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(37h);

6-Methoxy-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-vl]-phenoxv}-decvloxv)-3-methoxv-phenvl]-2, 3-dihvdro-1H-quinazolin-4-one(37i);

(Z)-2-(3-methoxy-4-(2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) ethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39a);

(Z)-2-(3-methoxy-4-(3-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) propoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39b);

(Z)-2-(3-methoxy-4-(4-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) butoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39c);

(Z)-2-(3-methoxy-4-(5-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) pentyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39d);

(Z)-2-(3-methoxy-4-(6-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) hexyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39e);

(Z)-2-(3-methoxy-4-(7-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) heptyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39f);

(Z)-2-(3-methoxy-4-(8-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) octyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39g);

(Z)-2-(3-methoxy-4-(9-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) nonyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39h);

(Z)-2-(3-methoxy-4-(10-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy) decyloxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one(39i);

6-Chloro-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40a);

6-Chloro-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40b);

6-Chloro-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40c);

6-Chloro-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40d);

6-Chloro-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40e);

6-Chloro-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40f);

6-Chloro-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40g);

6-Chloro-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40h);

6-Chloro-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(40i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41a);

6-Methyl-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41b);

6-Methyl-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41d);

6-Methyl-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41e);

6-Methyl-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41g);

6-Methyl-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(41h);

6-Methyl-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(4li);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42a);

6-Methoxy-2-[3-Methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42b);

6-Methoxy-2-[3-Methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42d);

6-Methoxy-2-[3-Methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42e);

6-Methoxy-2-[3-Methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42g);

6-Methoxy-2-[3-Methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42h);

6-Methoxy-2-[3-Methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-quinazolin-4-one(42i);

(Z)-2-(4-(2-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) ethoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43a);

(Z)-2-(4-(3-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) propoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43b);

(Z)-2-(4-(4-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) butoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43c);

(Z)-2-(4-(5-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) pentyoxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43d);

(Z)-2-(4-(6-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) hexyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43e);

(Z)-2-(4-(7-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) heptyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43f);

(Z)-2-(4-(8-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) octyloxy)-3-methoxy phenvl)-2,3-dihydroquinazolin-4(1H)-one(43g);

(Z)-2-(4-(9-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) nonyloxy)-3-methoxy phenyl)-2,3-dihydroquinazolin-4(1H)-one(43h)

(Z)-2-(4-(10-(2,6-dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy) decyloxy)-3-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one(43i);

6-Chloro-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44a);

6-Chloro-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44b);

6-Chloro-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44c);

6-Chloro-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44d)

6-Chloro-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44e)

6-Chloro-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44f)

6-Chloro-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44g)

6-Chloro-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44h)

6-Chloro-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(44i)

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vin yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45a)

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45b)

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45c)

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45d)

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45e)

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45f)

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45g)

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45h)

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(45i)

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46a)

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxyl-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46b)

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46c)

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46d)

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46e)

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46f)

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46g)

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46h) and

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one(46i)

4. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids as claimed in claim 1 wherein the structural formulae of the representative compounds are:

5. Isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general formulae A as claimed in claim 1 for use as antitumour agents.

6. A process for the preparation of isoxazole/isoxazoline/combretastatin linked dihydroquinazolinone hybrids of general formulae A

Where in G =

or

or

If R = 3-OCH₃, R₁ = 5-OCH₃
If R = 4-OCH₃, R₁ = 5-H
X = H, Cl, CH₃, OCH₃
the said process comprising
reacting 2-[4-(n-Bromo-alkyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-quinazolin-4-one of formula 2

with the compounds of formulae 1a, 1b, 11a, 11b, 20a, 20b, 29a, 29b, 38a,38b









respectively in an aprotic water miscible organic solvent in the presence of anhydrous mild inorganic base at a temperature of 30°C for a period of about 24-48 hrs, followed by the removal of inorganic base by filtration and evaporating the organic solvent to obtain the resultant crude product and purifying it by column chromatography to obtain the desired products of formulae 3a-i to 6a-i, 7a-i to 10a-i, 12a-i to 15a-i, 16a-i to 19a-i, 21a-i to 24a-i, 25a-i to 28a-i, 30a-i to 33a-i, 34a-ito37a-i and 39a-i to 42a-i, 43a-i to 46a-i respectively.

7. Process as claimed in claim 6, wherein aprotic water miscible organic solvent is selected from the group consisting of dimethylformamide, acetone, acetonitrile and dimethyl sulfoxide.

8. Process as claimed in claim 6, wherein anhydrous mild inorganic base is selected from the group consisting of sodium carbonate or potassium carbonate.

Ansprüche

1. Isoxazol-/Isoxazolin-/Combretastatin-gebundene Dihydrochinazolinonhybride der allgemeinen Formel A

wobei G =

oder

oder

oder

R₂ = 2-OCH₃ und R₃ = 6-OCH₃ oder 6-H
X = H, Cl, CH₃, OCH₃.

2. Isoxazol-/Isoxazolin-/Combretastatin-gebundene Dihydrochinazolinonhybride nach Anspruch 1, wobei die Isoxazol-/Isoxazolin-/Combretastatin-gebundenen Dihydrochinazolinonhybride der Formel A durch die Verbindungen der allgemeinen Formeln 3a-i bis 6a-i, 7a-i bis 10a-i, 12a-i bis 15a-i, 16a-i bis 19a-i, 21a-i bis 24a-i, 25a-i bis 28a-i, 30a-i bis 33a-i, 34a-i bis 37a-i und 39a-i bis 42a-i, 43a-i bis 46a-i wiedergegeben werden

n = 1-9

n = 1-9

n= 1-9

n= 1-9

n = 1-9 wobei n = 1-9

3. Isoxazol-/Isoxazolin-/Combretastatin-gebundene Dihydrochinazolinonhybride nach Anspruch 1, wiedergegeben durch die Gruppe der folgenden Verbindungen:

2-[3-Methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3a);

2-[3-Methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3b);

2-[3-Methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3c);

2-[3-Methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3d);

2-[3-Methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3e);

2-[3-Methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3f);

2-[3-Methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3g);

2-[3-Methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3h);

2-[3-Methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (3i);

6-Chlor-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (4a);

6-Chlor-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-o (4b);

6-Chlor-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4c);

6-Chlor-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4d);

6-Chlor-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4e);

6-Chlor-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4f);

6-Chlor-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4g);

6-Chlor-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4h);

6-Chlor-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (4i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-hexyloxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5e) ;

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (5i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (6i);

2-[4-(2-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7a);

2-[4-(3-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7b);

2-[4-(4-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7c);

2-[4-(5-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7d);

2-[4-(6-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7e);

2-[4-(7-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7f);

2-[4-(8-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7g);

2-[4-(9-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7h);

2-[4-(10-{2,6-Dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (7i);

6-Chlor-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8a);

6-Chlor-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8b);

6-Chlor-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8c);

6-Chlor-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8d);

6-Chlor-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8e);

6-Chlor-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8f);

6-Chlor-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8g);

6-Chlor-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8h);

6-Chlor-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (8i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (9i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10a) ;

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (10i) ;

2-[3-Methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12a);

2-[3-Methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12b);

2-[3-Methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12c);

2-[3-Methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12d);

2-[3-Methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12e);

2-[3-Methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12f);

2-[3-Methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12g);

2-[3-Methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12h);

2-[3-Methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (12i);

6-Chlor-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13a);

6-Chlor-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13b);

6-Chlor-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13c);

6-Chlor-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13d) ;

6-Chlor-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13e);

6-Chlor-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13f);

6-Chlor-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13g);

6-Chlor-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13h);

6-Chlor-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (13i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (14i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15d) ;

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (15i);

2-[4-(2-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16a);

2-[4-(3-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16b);

2-[4-(4-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16c);

2-[4-(5-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16d);

2-[4-(6-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16e);

2-[4-(7-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16f);

2-[4-(8-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16g);

2-[4-(9-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16h);

2-[4-(10-{2,6-Dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (16i);

6-Chlor-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17a);

6-Chlor-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17b);

6-Chlor-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17c);

6-Chlor-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17d);

6-Chlor-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17e);

6-Chlor-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17f);

6-Chlor-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17g);

6-Chlor-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17h);

6-Chlor-2-[4-(10-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (17i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18g) ;

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (18i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19f) ;

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (19i);

2-(3-Methoxy-4-(2-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)ethoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21a) ;

2-(3-Methoxy-4-(3-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)propoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21b);

2-(3-Methoxy-4-(4-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)butoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21c) ;

2-(3-Methoxy-4-(5-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)pentyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21d);

2-(3-Methoxy-4-(6-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)hexyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21e);

2-(3-Methoxy-4-(7-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)heptyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21f);

2-(3-Methoxy-4-(8-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)octyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21g) ;

2-(3-Methoxy-4-(9-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)nonyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21h);

2-(3-Methoxy-4-(10-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)-isoxazol-3-yl)-phenoxy)decyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (21i) ;

6-Chlor-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22a);

6-Chlor-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22b);

6-Chlor-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22c);

6-Chlor-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22d);

6-Chlor-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22e);

6-Chlor-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22f);

6-Chlor-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22g);

6-Chlor-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22h);

6-Chlor-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (22i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (23i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (24i);

2-(4-(2-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-ethoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25a);

2-(4-(3-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-propoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25b);

2-(4-(4-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-butoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25c);

2-(4-(5-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-pentyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25d);

2-(4-(6-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-hexyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25e);

2-(4-(7-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-heptyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25f);

2-(4-(8-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-octyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25g);

2-(4-(9-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-nonyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25h);

2-(4-(10-(2,6-Dimethoxy-4-(5-(3,4,5-trimethoxyphenyl)isoxazol-3-yl)-phenoxy)-decyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (25i);

6-Chlor-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26a);

6-Chlor-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26b);

6-Chlor-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26c);

6-Chlor-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26d);

6-Chlor-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26e);

6-Chlor-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26f);

6-Chlor-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26g);

6-Chlor-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26h);

6-Chlor-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (26i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27c) ;

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (27i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28h);

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[5-(3,4,5-trimethoxy-phenyl)-isoxazol-3-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (28i);

2-(3-Methoxy-4-(2-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)ethoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30a);

2-(3-Methoxy-4-(3-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)propoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30b);

2-(3-Methoxy-4-(4-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)butoxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30c);

2-(3-Methoxy-4-(5-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)pentyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30d);

2-(3-Methoxy-4-(6-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)hexyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30e);

2-(3-Methoxy-4-(7-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)heptyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30f);

2-(3-Methoxy-4-(8-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)octyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30g);

2-(3-Methoxy-4-(9-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)nonyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30h);

2-(3-Methoxy-4-(10-(2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-isoxazol-5-yl)-phenoxy)decyloxy)phenyl)-2,3-dihydrochinazolin-4(1H)-on (30i) ;

6-Chlor-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31a);

6-Chlor-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31b);

6-Chlor-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31c);

6-Chlor-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31d);

6-Chlor-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31e);

6-Chlor-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31f);

6-Chlor-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31g);

6-Chlor-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31h);

6-Chlor-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (31i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (32i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (33i);

2-(4-(2-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-ethoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34a);

2-(4-(3-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-propoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34b);

2-(4-(4-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-butoxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34c);

2-(4-(5-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-pentyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34d);

2-(4-(6-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-hexyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34e);

2-(4-(7-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-heptyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34f);

2-(4-(8-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-octyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34g);

2-(4-(9-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-nonyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34h);

2-(4-(10-(2,6-Dimethoxy-4-(3-(3,4,5-trimethoxyphenyl)isoxazol-5-yl)-phenoxy)-decyloxy)-3-methoxyphenyl)-2,3-dihydrochinazolin-4(1H)-on (34i);

6-Chlor-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35a);

6-Chlor-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35b);

6-Chlor-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35c);

6-Chlor-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35d);

6-Chlor-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35e);

6-Chlor-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35f);

6-Chlor-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35g);

6-Chlor-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35h);

6-Chlor-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (35i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36h);

6-Methyl-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (36i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-butyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37h);

6-Methoxy-2-[10-(4-{2,6-dimethoxy-4-[3-(3,4,5-trimethoxy-phenyl)-isoxazol-5-yl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (37i);

(Z)-2-(3-Methoxy-4-(2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-ethoxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39a);

(Z)-2-(3-Methoxy-4-(3-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-propoxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39b);

(Z)-2-(3-Methoxy-4-(4-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-butoxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39c);

(Z)-2-(3-Methoxy-4-(5-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-pentyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39d);

(Z)-2-(3-Methoxy-4-(6-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-hexyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39e);

(Z)-2-(3-Methoxy-4-(7-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-heptyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39f);

(Z)-2-(3-Methoxy-4-(8-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-octyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39g);

(Z)-2-(3-Methoxy-4-(9-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-nonyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39h);

(Z)-2-(3-Methoxy-4-(10-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)-decyloxy)-phenyl)-2,3-dihydrochinazolin-4(1H)-on (39i);

6-Chlor-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40a);

6-Chlor-2-[3-methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40b);

6-Chlor-2-[3-methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40c);

6-Chlor-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40d);

6-Chlor-2-[3-methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40e);

6-Chlor-2-[3-methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40f);

6-Chlor-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40g);

6-Chlor-2-[3-methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40h);

6-Chlor-2-[3-methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (40i);

6-Methyl-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41a);

6-Methyl-2-[3-methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41b);

6-Methyl-2-[3-methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41c);

6-Methyl-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41d);

6-Methyl-2-[3-methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41e);

6-Methyl-2-[3-methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41f);

6-Methyl-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41g);

6-Methyl-2-[3-methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41h);

6-Methyl-2-[3-methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (41i);

6-Methoxy-2-[3-methoxy-4-(2-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42a);

6-Methoxy-2-[3-methoxy-4-(3-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42b);

6-Methoxy-2-[3-methoxy-4-(4-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42c);

6-Methoxy-2-[3-methoxy-4-(5-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42d);

6-Methoxy-2-[3-methoxy-4-(6-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42e);

6-Methoxy-2-[3-methoxy-4-(7-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42f);

6-Methoxy-2-[3-methoxy-4-(8-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42g);

6-Methoxy-2-[3-methoxy-4-(9-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42h);

6-Methoxy-2-[3-methoxy-4-(10-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-phenyl]-2,3-dihydro-1H-chinazolin-4-on (42i);

(Z)-2-(4-(2-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-ethoxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43a);

(Z)-2-(4-(3-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-propoxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43b);

(Z)-2-(4-(4-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-butoxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43c);

(Z)-2-(4-(5-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-pentyoxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43d);

(Z)-2-(4-(6-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-hexyloxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43e);

(Z)-2-(4-(7-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-heptyloxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43f);

(Z)-2-(4-(8-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-octyloxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43g);

(Z)-2-(4-(9-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-nonyloxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43h);

(Z)-2-(4-(10-(2,6-Dimethoxy-4-(3,4,5-trimethoxystyryl)phenoxy)-decyloxy)-3-methoxy-phenyl)-2,3-dihydrochinazolin-4(1H)-on (43i);

6-Chlor-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44a);

6-Chlor-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44b);

6-Chlor-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44c);

6-Chlor-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44d);

6-Chlor-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44e);

6-Chlor-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44f);

6-Chlor-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44g);

6-Chlor-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44h);

6-Chlor-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (44i);

6-Methyl-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45a);

6-Methyl-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45b);

6-Methyl-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45c);

6-Methyl-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45d);

6-Methyl-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45e);

6-Methyl-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45f);

6-Methyl-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45g);

6-Methyl-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45h);

6-Methyl-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (45i);

6-Methoxy-2-[4-(2-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46a);

6-Methoxy-2-[4-(3-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-propoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46b);

6-Methoxy-2-[4-(4-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-butoxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46c);

6-Methoxy-2-[4-(5-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-pentyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46d);

6-Methoxy-2-[4-(6-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-hexyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46e);

6-Methoxy-2-[4-(7-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-heptyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46f);

6-Methoxy-2-[4-(8-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-octyloxy)-3-methoxy-phenyl]-2,3-dihydro-1 H-chinazolin-4-on (46g);

6-Methoxy-2-[4-(9-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-nonyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46h) und

6-Methoxy-2-[4-(10-{2,6-dimethoxy-4-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-decyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on (46i).

4. Isoxazol-/Isoxazolin-/Combretastatin-gebundene Dihydrochinazolinonhybride nach Anspruch 1, wobei die Strukturformeln der repräsentativen Verbindungen wie folgt sind:

5. Isoxazol-/Isoxazolin-/Combretastatin-gebundene Dihydrochinazolinonhybride der allgemeinen Formel A nach Anspruch 1 zur Verwendung als Antitumormittel.

6. Verfahren zur Herstellung von Isoxazol-/Isoxazolin-/Combretastatin-gebundenen Dihydrochinazolinonhybriden der allgemeinen Formel A

wobei G =

oder

oder

wenn R = 3-OCH₃, R₁ = 5-OCH₃
wenn R = 4-OCH₃, R₁ = 5-H
X = H, Cl, CH₃, OCH₃,
wobei das Verfahren die Umsetzung von 2-[4-(n-Brom-alkyloxy)-3-methoxy-phenyl]-2,3-dihydro-1H-chinazolin-4-on der Formel 2

mit den Verbindungen der Formeln 1a, 1b, 11a, 11b, 20a, 20b, 29a, 29b, 38a, 38b









in einem aprotischen wassermischbaren organischen Lösungsmittel in Gegenwart einer wasserfreien schwachen anorganischen Base bei einer Temperatur von 30°C über einen Zeitraum von etwa 24-48 Stunden, gefolgt vom Entfernen der anorganischen Base durch Filtrieren und Abdampfen des organischen Lösungsmittels unter Erhalt des resultierenden Rohprodukts und dessen Aufreinigung durch Säulenchromatographie unter Erhalt der gewünschten Produkte der Formeln 3a-i bis 6a-i, 7a-i bis 10a-i, 12a-i bis 15a-i, 16a-i bis 19a-i, 21a-i bis 24a-i, 25a-i bis 28a-i, 30a-i bis 33a-i, 34a-i bis 37a-i bzw. 39a-i bis 42a-i, 43a-i bis 46a-i umfasst.

7. Verfahren nach Anspruch 6, wobei das aprotische wassermischbare organische Lösungsmittel aus der aus Dimethylformamid, Aceton, Acetonitril und Dimethylsulfoxid bestehenden Gruppe ausgewählt ist.

8. Verfahren nach Anspruch 6, wobei die wasserfreie schwache anorganische Base aus der aus Natriumcarbonat und Kaliumcarbonat bestehenden Gruppe ausgewählt ist.

Revendications

1. Hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine de formules générales A

où G =

ou

ou

R₂ = 2-OCH₃ et R₃ = 6-OCH₃ ou 6-H
X = H, Cl, CH₃, OCH₃

2. Hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine selon la revendication 1 dans lesquels les hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine de formule A sont représentés par les composés de formule générale 3a-i à 6a-i, 7a-i à 10a-i, 12a-i à 15a-i, 16a-i à 19a-i, 21a-i à 24a-i, 25a-i à 28a-i, 30a-i à 33a-i, 34a-i à 37a-i et 39a-i à 42a-i, 43a-i à 46a-i

n = 1-9

n = 1-9

n = 1-9

n = 1-9

où n = 1-9

3. Hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine selon la revendication 1 qui sont représentés par le groupe des composés suivants :

2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3a) ;

2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3b) ;

2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3c) ;

2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3d) ;

2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3e) ;

2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3f) ;

2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3g) ;

2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3h) ;

2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (3i) ;

6-chloro-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4a) ;

6-chloro-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4b) ;

6-chloro-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4c) ;

6-chloro-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4d) ;

6-chloro-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4e) ;

6-chloro-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4f) ;

6-chloro-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4g)

6-chloro-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4h) ;

6-chloro-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (4i) ;

6-méthyl-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5a) ;

6-méthyl-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5b) ;

6-méthyl-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5c) ;

6-méthyl-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5d) ;

6-méthyl-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-hexyloxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5e) ;

6-méthyl-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5f) ;

6-méthyl-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5g) ;

6-méthyl-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5h) ;

6-méthyl-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (5i) ;

6-méthoxy-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6a) ;

6-méthoxy-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6b) ;

6-méthoxy-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6c) ;

6-méthoxy-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6d) ;

6-méthoxy-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6e) ;

6-méthoxy-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6f) ;

6-méthoxy-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6g) ;

6-méthoxy-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6h) ;

6-méthoxy-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (6i) ;

2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7a) ;

2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7b) ;

2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7c) ;

2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7d) ;

2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7e) ;

2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7f) ;

2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7g) ;

2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (7h) ;

2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro 1H-quinazolin-4-one (7i) ;

6-chloro-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8a) ;

6-chloro-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8b) ;

6-chloro-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8c) ;

6-chloro-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8d) ;

6-chloro-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8e) ;

6-chloro-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8f) ;

6-chloro-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8g) ;

6-chloro-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8h) ;

6-chloro-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (8i) ;

6-méthyl-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9a) ;

6-méthyl-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9b) ;

6-méthyl-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9c) ;

6-méthyl-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9d) ;

6-méthyl-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9e) ;

6-méthyl-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9f) ;

6-méthyl-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9g) ;

6-méthyl-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9h) ;

6-méthyl-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (9i) ;

6-méthoxy-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10a) ;

6-méthoxy-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10b) ;

6-méthoxy-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10c) ;

6-méthoxy-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10d) ;

6-méthoxy-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10e) ;

6-méthoxy-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10f) ;

6-méthoxy-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10g) ;

6-méthoxy-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10h) ;

6-méthoxy-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (10i) ;

2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12a) ;

2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12b) ;

2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12c) ;

2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12d) ;

2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5 dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12e) ;

2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12f) ;

2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12g) ;

2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12h) ;

2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-dedyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (12i) ;

6-chloro-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13a) ;

6-chloro-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13b) ;

6-chloro-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13c) ;

6-chloro-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13d) ;

6-chloro-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13e) ;

6-chloro-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13f) ;

6-chloro-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13g) ;

6-chloro-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13h) ;

6-chloro-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (13i) ;

6-méthyl-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14a) ;

6-méthyl-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14b) ;

6-méthyl-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14c) ;

6-méthyl-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14d) ;

6-méthyl-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14e) ;

6-méthyl-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14f) ;

6-méthyl-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14g) ;

6-méthyl-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14h) ;

6-méthyl-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (14i) ;

6-méthoxy-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15a) ;

6-méthoxy-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15b) ;

6-méthoxy-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15c) ;

6-méthoxy-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15d) ;

6-méthoxy-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H quinazolin-4-one (15e) ;

6-méthoxy-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15f) ;

6-méthoxy-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15g) ;

6-méthoxy-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15h) ;

6-méthoxy-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (15i) ;

2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16a) ;

2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16b) ;

2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16c) ;

2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16d) ;

2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16e) ;

2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16f) ;

2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16g) ;

2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16h) ;

2-[4-(10-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (16i) ;

6-chloro-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17a) ;

6-chloro-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17b) ;

6-chloro-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17c) ;

6-chloro-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17d) ;

6-chloro-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17e) ;

6-chloro-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17f) ;

6-chloro-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17g) ;

6-chloro-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17h) ;

6-chloro-2-[4-(10-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (17i) ;

6-méthyl-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18a) ;

6-méthyl-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18b) ;

6-méthyl-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18c) ;

6-méthyl-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18d) ;

6-méthyl-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18e) ;

6-méthyl-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18f) ;

6-méthyl-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18g) ;

6-méthyl-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18h) ;

6-méthyl-2-[4-(10-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (18i) ;

6-méthoxy-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19a) ;

6-méthoxy-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19b) ;

6-méthoxy-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19c) ;

6-méthoxy-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19d) ;

6-méthoxy-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19e) ;

6-méthoxy-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19f) ;

6-méthoxy-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19g) ;

6-méthoxy-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19h) ;

6-méthoxy-2-[4-(10-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-4,5-dihydro-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (19i) ;

2-(3-méthoxy-4-(2-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)éthoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21a) ;

2-(3-méthoxy-4-(3-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)propoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21b) ;

2-(3-méthoxy-4-(4-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)butoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21c) ;

2-(3-méthoxy-4-(5-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)pentyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21d) ;

2-(3-méthoxy-4-(6-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)hexyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21e)- ;

2-(3-méthoxy-4-(7-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)heptyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21f) ;

2-(3-méthoxy-4-(8-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)octyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21g) ;

2-(3-méthoxy-4-(9-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)nonyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21h) ;

2-(3-méthoxy-4-(10-(2-méthoxy-5-(5-(3,4,5-triméthoxyphényl)-isoxazol-3-yl)-phénoxy)décyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (21i) ;

6-chloro-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22a) ;

6-chloro-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22b) ;

6-chloro-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22c) ;

6-chloro-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22d) ;

6-chloro-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22e) ;

6-chloro-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22f) ;

6-chloro-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22g) ;

6-chloro-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22h) ;

6-chloro-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (22i) ;

6-méthyl-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23a) ;

6-méthyl-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23b) ;

6-méthyl-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23c) ;

6-méthyl-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23d) ;

6-méthyl-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23e) ;

6-méthyl-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23f) ;

6-méthyl-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23g) ;

6-méthyl-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23h) ;

6-méthyl-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (23i) ;

6-méthoxy-2-[3-méthoxy-4-(2-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24a) ;

6-méthoxy-2-[3-méthoxy-4-(3-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24b) ;

6-méthoxy-2-[3-méthoxy-4-(4-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24c) ;

6-méthoxy-2-[3-méthoxy-4-(5-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24d) ;

6-méthoxy-2-[3-méthoxy-4-(6-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24e) ;

6-méthoxy-2-[3-méthoxy-4-(7-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24f) ;

6-méthoxy-2-[3-méthoxy-4-(8-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24g) ;

6-méthoxy-2-[3-méthoxy-4-(9-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24h) ;

6-méthoxy-2-[3-méthoxy-4-(10-{2-méthoxy-5-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (24i) ;

2-(4-(2-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-éthoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25a) ;

2-(4-(3-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-propoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25b) ;

2-(4-(4-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-butoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25c) ;

2-(4-(5-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-pentyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25d) ;

2-(4-(6-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-hexyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25e) ;

2-(4-(7-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-heptyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25f) ;

2-(4-(8-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-octyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25g) ;

2-(4-(9-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-nonyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25h) ;

2-(4-(10-(2,6-diméthoxy-4-(5-(3,4,5-triméthoxyphényl)isoxazol-3-yl)-phénoxy)-décyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (25i) ;

6-chloro-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26a) ;

6-chloro-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26b) ;

6-chloro-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26c) ;

6-chloro-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26d) ;

6-chloro-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26e) ;

6-chloro-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26f) ;

6-chloro-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26g) ;

6-chloro-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26h) ;

6-chloro-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (26i) ;

6-méthyl-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27a) ;

6-méthyl-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27b) ;

6-méthyl-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27c) ;

6-méthyl-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27d) ;

6-méthyl-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27e) ;

6-méthyl-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27f) ;

6-méthyl-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27g) ;

6-méthyl-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27h) ;

6-méthyl-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (27i) ;

6-méthoxy-2-[4-(2-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28a)

6-méthoxy-2-[4-(3-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28b) ;

6-méthoxy-2-[4-(4-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28c) ;

6-méthoxy-2-[4-(5-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28d) ;

6-méthoxy-2-[4-(6-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28e) ;

6-méthoxy-2-[4-(7-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28f) ;

6-méthoxy-2-[4-(8-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28g) ;

6-méthoxy-2-[4-(9-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28h) ;

6-méthoxy-2-[4-(10-{2,6-diméthoxy-4-[5-(3,4,5-triméthoxy-phényl)-isoxazol-3-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (28i) ;

2-(3-méthoxy-4-(2-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)éthoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30a) ;

2-(3-méthoxy-4-(3-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)propoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30b) ;

2-(3-méthoxy-4-(4-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)butoxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30c) ;

2-(3-méthoxy-4-(5-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)pentyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30d) ;

2-(3-méthoxy-4-(6-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)hexyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30e) ;

2-(3-méthoxy-4-(7-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)heptyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30f) ;

2-(3-méthoxy-4-(8-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)octyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30g) ;

2-(3-méthoxy-4-(9-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)nonyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30h) ;

2-(3-méthoxy-4-(10-(2-méthoxy-5-(3-(3,4,5-triméthoxyphényl)-isoxazol-5-yl)-phénoxy)décyloxy)phényl)-2,3-dihydroquinazolin-4(1H)-one (30i) ;

6-chloro-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31a) ;

6-chloro-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31b) ;

6-chloro-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31c) ;

6-chloro-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31d) ;

6-chloro-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31e) ;

6-chloro-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31f) ;

6-chloro-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31g) ;

6-chloro-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31h) ;

6-chloro-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (31i) ;

6-méthyl-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32a) ;

6-méthyl-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32b) ;

6-méthyl-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32c) ;

6-méthyl-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32d) ;

6-méthyl-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32e) ;

6-méthyl-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32f) ;

6-méthyl-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32g) ;

6-méthyl-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32h) ;

6-méthyl-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (32i) ;

6-méthoxy-2-[3-méthoxy-4-(2-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33a) ;

6-méthoxy-2-[3-méthoxy-4-(3-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33b) ;

6-méthoxy-2-[3-méthoxy-4-(4-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33c) ;

6-méthoxy-2-[3-méthoxy-4-(5-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33d) ;

6-méthoxy-2-[3-méthoxy-4-(6-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33e) ;

6-méthoxy-2-[3-méthoxy-4-(7-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33f) ;

6-méthoxy-2-[3-méthoxy-4-(8-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33g) ;

6-méthoxy-2-[3-méthoxy-4-(9-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33h) ;

6-méthoxy-2-[3-méthoxy-4-(10-{2-méthoxy-5-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (33i) ;

2-(4-(2-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-éthoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34a) ;

2-(4-(3-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-propoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34b) ;

2-(4-(4-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-butoxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34c) ;

2-(4-(5-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-pentyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34d) ;

2-(4-(6-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-hexyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34e) ;

2-(4-(7-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-heptyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34f) ;

2-(4-(8-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-octyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34g) ; 2-(4-(9-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-nonyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34h) ;

2-(4-(10-(2,6-diméthoxy-4-(3-(3,4,5-triméthoxyphényl)isoxazol-5-yl)-phénoxy)-décyloxy)-3-méthoxyphényl)-2,3-dihydroquinazolin-4(1H)-one (34i) ;

6-chloro-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35a) ;

6-chloro-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35b) ;

6-chloro-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35c) ;

6-chloro-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35d) ;

6-chloro-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35e) ;

6-chloro-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35f) ;

6-chloro-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35g) ;

6-chloro-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35h) ;

6-chloro-2-[10-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (35i) ;

6-méthyl-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36a) ;

6-méthyl-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36b) ;

6-méthyl-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36c) ;

6-méthyl-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36d) ;

6-méthyl-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36e) ;

6-méthyl-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36f) ;

6-méthyl-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36g) ;

6-méthyl-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36h) ;

6-méthyl-2-[10-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (36i) ;

6-méthoxy-2-[4-(2-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37a) ;

6-méthoxy-2-[4-(3-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37b) ;

6-méthoxy-2-[4-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-butyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37c) ;

6-méthoxy-2-[4-(5-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37d) ;

6-méthoxy-2-[4-(6-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37e) ;

6-méthoxy-2-[4-(7-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37f) ;

6-méthoxy-2-[4-(8-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37g) ;

6-méthoxy-2-[4-(9-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37h) ;

6-méthoxy-2-[10-(4-{2,6-diméthoxy-4-[3-(3,4,5-triméthoxy-phényl)-isoxazol-5-yl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (37i) ;

(Z)-2-(3-méthoxy-4-(2-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-éthoxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39a) ;

(Z)-2-(3-méthoxy-4-(3-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-propoxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39b) ;

(Z)-2-(3-méthoxy-4-(4-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-butoxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39c) ;

(Z)-2-(3-méthoxy-4-(5-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-pentyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39d) ;

(Z)-2-(3-méthoxy-4-(6-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-hexyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39e) ;

(Z)-2-(3-méthoxy-4-(7-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-heptyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39f) ;

(Z)-2-(3-méthoxy-4-(8-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-octyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39g) ;

(Z)-2-(3-méthoxy-4-(9-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-nonyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39h) ;

(Z)-2-(3-méthoxy-4-(10-(2-méthoxy-5-(3,4,5-triméthoxystyryl)phénoxy)-décyloxy)-phényl)-2,3-dihydroquinazolin-4(1H)-one (39i) ;

6-chloro-2-[3-méthoxy-4-(2-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40a) ;

6-chloro-2-[3-méthoxy-4-(3-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40b) ;

6-chloro-2-[3-méthoxy-4-(4-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40c) ;

6-chloro-2-[3-méthoxy-4-(5-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40d) ;

6-chloro-2-[3-méthoxy-4-(6-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40e) ;

6-chloro-2-[3-méthoxy-4-(7-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40f) ;

6-chloro-2-[3-méthoxy-4-(8-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40g) ;

6-chloro-2-[3-méthoxy-4-(9-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40h) ;

6-chloro-2-[3-méthoxy-4-(10-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (40i) ;

6-méthyl-2-[3-méthoxy-4-(2-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41a) ;

6-méthyl-2-[3-méthoxy-4-(3-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41b) ;

6-méthyl-2-[3-méthoxy-4-(4-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41c) ;

6-méthyl-2-[3-méthoxy-4-(5-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41d) ;

6-méthyl-2-[3-méthoxy-4-(6-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41e) ;

6-méthyl-2-[3-méthoxy-4-(7-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41f) ;

6-méthyl-2-[3-méthoxy-4-(8-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41g) ;

6-méthyl-2-[3-méthoxy-4-(9-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41h) ;

6-méthyl-2-[3-méthoxy-4-(10-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (41i) ;

6-méthoxy-2-[3-méthoxy-4-(2-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42a) ;

6-méthoxy-2-[3-méthoxy-4-(3-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42b) ;

6-méthoxy-2-[3-méthoxy-4-(4-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42c) ;

6-méthoxy-2-[3-méthoxy-4-(5-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42d) ;

6-méthoxy-2-[3-méthoxy-4-(6-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42e) ;

6-méthoxy-2-[3-méthoxy-4-(7-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42f) ;

6-méthoxy-2-[3-méthoxy-4-(8-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42g) ;

6-méthoxy-2-[3-méthoxy-4-(9-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42h) ;

6-méthoxy-2-[3-méthoxy-4-(10-{2-méthoxy-5-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-phényl]-2,3-dihydro-1H-quinazolin-4-one (42i) ;

(Z)-2-(4-(2-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-éthoxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43a) ;

(Z)-2-(4-(3-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-propoxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43b) ;

(Z)-2-(4-(4-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-butoxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43c) ;

(Z)-2-(4-(5-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-pentyoxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43d) ;

(Z)-2-(4-(6-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-hexyloxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43e) ;

(Z)-2-(4-(7-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-heptyloxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43f) ;

(Z)-2-(4-(8-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-octyloxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43g) ;

(Z)-2-(4-(9-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-nonyloxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43h)

(Z)-2-(4-(10-(2,6-diméthoxy-4-(3,4,5-triméthoxystyryl)phénoxy)-décyloxy)-3-méthoxy-phényl)-2,3-dihydroquinazolin-4(1H)-one (43i) ;

6-chloro-2-[4-(2-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44a) ;

6-chloro-2-[4-(3-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44b) ;

6-chloro-2-[4-(4-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44c) ;

6-chloro-2-[4-(5-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44d)

6-chloro-2-[4-(6-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44e)

6-chloro-2-[4-(7-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44f)

6-chloro-2-[4-(8-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44g)

6-chloro-2-[4-(9-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44h)

6-chloro-2-[4-(10-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (44i) 6-méthyl-2-[4-(2-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45a)

6-méthyl-2-[4-(3-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45b)

6-méthyl-2-[4-(4-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45c)

6-méthyl-2-[4-(5-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45d)

6-méthyl-2-[4-(6-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45e)

6-méthyl-2-[4-(7-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45f)

6-méthyl-2-[4-(8-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45g)

6-méthyl-2-[4-(9-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45h)

6-méthyl-2-[4-(10-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (45i)

6-méthoxy-2-[4-(2-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-éthoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46a)

6-méthoxy-2-[4-(3-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-propoxy)-3-méthoxy-phényl]-2,3∼dihydro-1H-quinazolin-4-one (46b)

6-méthoxy-2-[4-(4-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-butoxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46c)

6-méthoxy-2-[4-(5-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-pentyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46d)

6-méthoxy-2-[4-(6-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-hexyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46e)

6-méthoxy-2-[4-(7-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-heptyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46f)

6-méthoxy-2-[4-(8-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-octyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46g) ;

6-méthoxy-2-[4-(9-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-nonyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46h) et

6-méthoxy-2-[4-(10-{2,6-diméthoxy-4-[2-(3,4,5-triméthoxy-phényl)-vinyl]-phénoxy}-décyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one (46i).

4. Hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine selon la revendication 1 dans lesquels les formules structurales des composés représentatifs sont :

5. Hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine de formules générales A, selon la revendication 1 pour utilisation en tant qu'agents antitumoraux.

6. Procédé de préparation d'hybrides de dihydroquinazolinone liée à l'isoxazole / isoxazoline / combrétastatine de formules générales A

où G =

ou

ou

Si R = 3-OCH₃, R₁ = 5-OCH₃
Si R = 4-OCH₃, R₁ = 5-H
X = H, Cl, CH₃, OCH₃
ledit procédé comprenant
la réaction de 2-[4-(n-bromo-alkyloxy)-3-méthoxy-phényl]-2,3-dihydro-1H-quinazolin-4-one of formula 2.

avec les composés de formules 1a, 1b, 11a, 11b, 20a, 20b, 29a, 29b, 38a, 38b









respectivement dans un solvant organique miscible dans l'eau aprotique en présence d'une base inorganique légère anhydre à une température de 30 °C pendant une période d'environ 24 à 48 heures, suivie par l'élimination de la base inorganique par filtration et évaporation du solvant organique pour obtenir le produit brut résultant et purification de celui-ci par chromatographie sur colonne pour obtenir les produits souhaités de formules 3a-i à 6a-i, 7a-i à 10a-i, 12a-i à 15a-i, 16a-i à 19a-i, 21a-i à 24a-i, 25a-i à 28a-i, 30a-i à 33a-i, 34a-i à 37a-i et 39a-i à 42a-i, 43a-i à 46a-i respectivement.

7. Procédé selon la revendication 6, dans lequel le solvant organique miscible dans l'eau aprotique est choisi dans le groupe constitué des diméthylformamide, acétone, acétonitrile et diméthylsulfoxyde.

8. Procédé selon la revendication 6, dans lequel la base inorganique faible anhydre est choisie dans le groupe constitué du carbonate de sodium et du carbonate de potassium.