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(11)

EP 2 350 072 A1

(12)

(43) Date of publication: 03.08.2011 Bulletin 2011/31 (21) Application number: 09748190.7 (22) Date of filing: 26.10.2009

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61K 31/4439(2006.01) C07D 491/113(2006.01) A61P 25/18(2006.01) (86) International application number: PCT/US2009/062071 (87) International publication number: WO 2010/062559 (03.06.2010 Gazette 2010/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 28.10.2008 US 108962 P (71) Applicant: Schering Corporation Kenilworth, NJ 07033-0530 (US)

(72) Inventors: HO, Ginny D Murray Hill New Jersey 07974 (US) YANG, Shu-Wei Edison New Jersey 08820 (US) SMITH, Elizabeth M Verona New Jersey 07044 (US) MCELROY, William Thomas Plainfield New Jersey 07060 (US) BASU, Kallol Piscataway New Jersey 08854 (US) SMOTRYSKI, Jennifer Mountainside New Jersey 07092 (US) TAN, Zheng Edison New Jersey 08820 (US) MCKITTRICK, Brian A. New Vernon New Jersey 07976 (US) TULSHIAN, Deen B. Lebanon New Jersey 08833 (US) (74) Representative: Buchan, Gavin MacNicol  Merck Sharp & Dohme Limited European Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)