(19)

(11)

EP 2 352 829 A1

(12)

(43) Date of publication: 10.08.2011 Bulletin 2011/32 (21) Application number: 09741517.8 (22) Date of filing: 08.10.2009

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61P 31/14(2006.01) A61K 31/713(2006.01) (86) International application number: PCT/US2009/059944 (87) International publication number: WO 2010/042683 (15.04.2010 Gazette 2010/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 08.10.2008 US 103609 P (71) Applicant: Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center Charlotte, NC 28232 (US)	(72) Inventors: BONKOVSKY, Herbert, L. Charlotte, NC 28203 (US) HOU, Weihong Weddington, NC 28104 (US) (74) Representative: Vial, Lionel et al Cabinet Orès 36, rue de Saint-Pétersbourg 75008 Paris 75008 Paris (FR)