(19)
(11) EP 2 355 843 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.08.2017 Bulletin 2017/31

(45) Mention of the grant of the patent:
07.06.2017 Bulletin 2017/23

(21) Application number: 09832462.7

(22) Date of filing: 09.12.2009
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
C07K 16/32(2006.01)
(86) International application number:
PCT/US2009/067264
(87) International publication number:
WO 2010/068647 (17.06.2010 Gazette 2010/24)

(54)

VACCINE FOR THE PREVENTION OF BREAST CANCER RECURRENCE

IMPFSTOFF ZUR PRÄVENTION VON REZIDIVIERENDEM BRUSTKREBS

VACCIN POUR LA PRÉVENTION DE LA RÉCURRENCE DU CANCER DU SEIN


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 10.12.2008 US 121220 P

(43) Date of publication of application:
17.08.2011 Bulletin 2011/33

(60) Divisional application:
17174362.8

(73) Proprietor: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Bethesda, MD 20817 (US)

(72) Inventors:
  • PEOPLES, George
    San Antonio, TX 78209 (US)
  • PONNIAH, Sathibalan
    Columbia, MD 21044 (US)

(74) Representative: Müller Fottner Steinecke 
Rechtsanwalts- und Patentanwaltspartnerschaft mbB Postfach 31 01 40
80102 München
80102 München (DE)


(56) References cited: : 
US-A- 5 550 214
US-B2- 7 211 432
US-A1- 2008 260 745
   
  • Peoples G E: "HER2/neu Vaccines for Cancer", , 16 November 2007 (2007-11-16), page 58PP, XP002691920, Retrieved from the Internet: URL:http://www.esmo.org/fileadmin/media/pr esentations/826/LCT10001553.pdf [retrieved on 2013-02-07]
  • Anonymous: "Selected Clinical Trials in Breast Cancer", Clinical Breast Cancer , 1 October 2007 (2007-10-01), pages 814-815, XP002691921, Retrieved from the Internet: URL:http://cigjournals.metapress.com/conte nt/8438658656p493l0/fulltext.pdf [retrieved on 2013-02-07]
  • CARMICHAEL M ET AL: "Clinical results of a phase I trial of a HER2/neu-derived peptide (GP2) vaccine in disease-free, node-negative breast cancer patients", BREAST CANCER RESEARCH AND TREATMENT, vol. 106, no. Suppl. 1, 13 December 2007 (2007-12-13), - 16 December 2007 (2007-12-16), pages S30-S31, XP002691922, & 30TH ANNUAL SAN ANTONIO BREAST CANCER SYMPOSIUM; SAN ANTONIO, TX, USA ISSN: 0167-6806
  • MITTENDORF ET AL: "Vaccination with a HER2/neu peptide induces intra- and inter-antigenic epitope spreading in patients with early stage breast cancer", SURGERY, vol. 139, no. 3, 1 March 2006 (2006-03-01) , pages 407-418, XP005338910, C.V. MOSBY CO., ST. LOUIS, US ISSN: 0039-6060, DOI: 10.1016/J.SURG.2005.06.059
  • MITTENDORF ET AL: "HER-2/neu Peptide Breast Cancer Vaccines: Current Status and Future Directions", BREAST DISEASES: A YEAR BOOK QUARTERLY, vol. 17, no. 4, 1 January 2007 (2007-01-01), pages 318-320, XP022090171, MOSBY, ST. LOUIS, MO, US ISSN: 1043-321X, DOI: 10.1016/S1043-321X(07)80101-9
  • ELIZABETH A MITTENDORF ET AL: "The E75 HER2/neu peptide vaccine", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 57, no. 10, 7 June 2008 (2008-06-07), pages 1511-1521, XP019624429, SPRINGER, BERLIN, DE ISSN: 1432-0851
  • ELIZABETH A MITTENDORF ET AL: "Evaluation of the HER2/neu-Derived Peptide GP2 for Use in a Peptide-Based Breast Cancer Vaccine Trial", CANCER, vol. 106, 1 January 2006 (2006-01-01), pages 2309-2317, XP007910301, AMERICAN CANCER SOCIETY, PHILADELPHIA, PA, US ISSN: 0008-543X, DOI: 10.1002/CNCR.21849
  • HOLMES J P ET AL: "Intra-antigenic epitope spreading in HLA-A2+breast cancer patients vaccinated with a MHC class I peptide (GP2) derived from the transmembrane region of HER2/NEU", JOURNAL OF IMMUNOTHERAPY, vol. 30, no. 8, 4 November 2007 (2007-11-04), page 896, XP009166967, LIPPINCOTT WILLIAMS & WILKINS, HAGERSTOWN, MD, US ISSN: 1524-9557
  • MARK G. CARMICHAEL ET AL: "Results of the first phase 1 clinical trial of the HER-2/ neu peptide (GP2) vaccine in disease-free breast cancer patients", CANCER, vol. 116, no. 2, 15 January 2010 (2010-01-15), pages 292-301, XP055140251, ISSN: 0008-543X, DOI: 10.1002/cncr.24756
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).