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EP 2 356 147 A1

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(43) Date of publication: 17.08.2011 Bulletin 2011/33 (21) Application number: 09748778.9 (22) Date of filing: 04.11.2009

(51) International Patent Classification (IPC):  C07K 16/22(2006.01) C07K 16/28(2006.01) A61K 39/395(2006.01) C07K 16/24(2006.01) C07K 16/00(2006.01) A61P 27/02(2006.01) (86) International application number: PCT/EP2009/064654 (87) International publication number: WO 2010/060768 (03.06.2010 Gazette 2010/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (30) Priority: 26.11.2008 US 323632 (71) Applicant: Glaxo Group Limited Middlesex UB6 0NN (GB)

(72) Inventors: CATCHPOLE, Ian, Richard Stevenage Hertfordshire SG1 2NY (GB) COOK, Fiona Stevenage Hertfordshire SG1 2NY (GB) GOUGH, Gerald, Wayne Stevenage Hertfordshire SG1 2NY (GB) JESPERS, Laurent Stevenage, Hertfordshire SG1 2NY (GB) STEWARD, Michael Stevenage Hertfordshire SG1 2NY (GB) (74) Representative: Wilson, Lynn Margaret  GlaxoSmithKline Corporate Intellectual Property (Patents) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)