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(11)

EP 2 358 685 A1

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(43) Date of publication: 24.08.2011 Bulletin 2011/34 (21) Application number: 08876427.9 (22) Date of filing: 24.10.2008

(51) International Patent Classification (IPC):  C07D 239/42(2006.01) C07C 43/23(2006.01) C07D 239/47(2006.01) (86) International application number: PCT/US2008/081054 (87) International publication number: WO 2010/047712 (29.04.2010 Gazette 2010/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (71) Applicant: Lexicon Pharmaceuticals, Inc. The Woodlands, TX 77381 (US)

(72) Inventors: BURGOON, Hugh, Alfred Hamilton NJ 08610 (US) KANAMARLAPUDI, Ramanaiah, C. Bridgewater NJ 08807 (US) PICKERSGILL, Iain, Fraser Newtown PA 18940 (US) SHI, Zhi-Cai Monmouth Junction NJ 08852 (US) WU, Wenxue Princeton Junction NJ 08550 (US) ZHANG, Haiming Pennington NJ 08534 (US) ZHAO, Matthew, Mangzhu Edison NJ 08820 (US) (74) Representative: Hewson, Timothy John et al Abel & Imray 20 Red Lion Street London, WC1R 4PQ London, WC1R 4PQ (GB)