Immunostimulatory nucleic acid molecules comprising GTCGTT motifs

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EP 2 360 252 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	12.04.2017 Bulletin 2017/15

(45)	Mention of the grant of the patent:
	08.02.2017 Bulletin 2017/06

(21)	Application number: 10186177.1

(22)	Date of filing: 30.10.1997

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International Patent Classification (IPC):

C12N 15/11^(2006.01)
C07H 21/04^(2006.01)
A61P 31/00^(2006.01)

C07H 21/00^(2006.01)
A61K 31/7125^(2006.01)
A61P 35/00^(2006.01)

(54)	Immunostimulatory nucleic acid molecules comprising GTCGTT motifs Immunostimulierende Nukleinsauremolekule die GTCGTT motive enthalten Molecules d'acide nucleique immunostimulantes comprenant des motifs GTCGTT

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

30.10.1996 US 738652

(43)	Date of publication of application:
	24.08.2011 Bulletin 2011/34

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	06115801.0 / 1746159
	97947311.3 / 0948510

(73)	Proprietors:
	University Of Iowa Research Foundation Iowa City, Iowa 52242-5500 (US) THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)

(72)	Inventors:
	Krieg, Arthur Wellesley, MA 02482 (US) Klinman, Dennis Potomac, MD 20854 (US) Weiner, George Iowa City, IA 52246 (US)

(74)	Representative: Jump, Timothy John Simon et al
	Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)

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References cited: :

WO-A-96/02555
WO-A-98/40100

WO-A-98/37919

KRIEG A M ET AL: "CPG MOTIFS IN BACTERIAL DNA TRIGGER DIRECT B-CELL ACTIVATION", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 374, 6 April 1995 (1995-04-06), pages 546-549, XP000197060, ISSN: 0028-0836, DOI: DOI:10.1038/374546A0
HARTMANN G ET AL: "CPG DNA:A POTENT SIGNAL FOR GROWTH, ACTIVATION, AND MATURATION OF HUMAN DENDRITIC CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, WASHINGTON, DC; US, vol. 96, 1 January 1999 (1999-01-01), pages 9305-9310, XP000919153, ISSN: 0027-8424, DOI: DOI:10.1073/PNAS.96.16.9305
HARTMANN G ET AL: "Mechanism and function of a newly identified CpG DNA motif in human primary B cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 2000 LNKD- PUBMED:10623843, vol. 164, no. 2, 15 January 2000 (2000-01-15), pages 944-953, XP002647150, ISSN: 0022-1767
HARTMANN G ET AL: "Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 FEB 2000 LNKD- PUBMED:10640783, vol. 164, no. 3, 1 February 2000 (2000-02-01), pages 1617-1624, XP002647151, ISSN: 0022-1767

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