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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIRO..CY..TRBGCZEEHUPLSK....IS..............................</B001EP><B005EP>J</B005EP><B007EP>JDIM360 Ver 1.28 (29 Oct 2014) -  2999001/0</B007EP></eptags></B000><B100><B110>2362226</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20160406</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>10187871.8</B210><B220><date>20060307</date></B220><B240><B241><date>20120228</date></B241><B242><date>20121203</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>74374</B310><B320><date>20050307</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20160406</date><bnum>201614</bnum></B405><B430><date>20110831</date><bnum>201135</bnum></B430><B450><date>20160217</date><bnum>201607</bnum></B450><B452EP><date>20150811</date></B452EP><B480><date>20160406</date><bnum>201614</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>G01N  33/68        20060101AFI20150601BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>C12Q   1/34        20060101ALI20150601BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P  25/28        20060101ALI20150601BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>Diagnostisches Verfahren für neurodegenerative Krankheiten basierend auf der Messung von SIRT1 Spiegel oder Aktivität</B542><B541>en</B541><B542>Diagnostic method for neurodegenerative diseases based on measurement of SIRT1 levels or activity</B542><B541>fr</B541><B542>Méthode diagnostique pour maladies neurodégénératives basée sur la mesure des niveaux ou de l'activité de SIRT1</B542></B540><B560><B561><text>WO-A-2005/002555</text></B561><B561><text>WO-A2-2006/068656</text></B561><B562><text>PORCU M ET AL: "The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 26, no. 2, 1 February 2005 (2005-02-01), pages 94-103, XP004727629, ISSN: 0165-6147, DOI: DOI:10.1016/J.TIPS.2004.12.009</text></B562><B562><text>ARAKI T ET AL: "Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 305, 13 August 2004 (2004-08-13), pages 1010-1013, XP003001697, ISSN: 0036-8075, DOI: DOI:10.1126/SCIENCE.1098014</text></B562></B560></B500><B600><B620><parent><pdoc><dnum><anum>06737459.5</anum><pnum>1863461</pnum></dnum><date>20060307</date></pdoc></parent></B620></B600><B700><B720><B721><snm>Sinclair, David</snm><adr><str>43 Newbrook Circle</str><city>Chestnut Hill, MA 02467</city><ctry>US</ctry></adr></B721><B721><snm>Tsai, Li-huei</snm><adr><str>26 Fresh Pond Parkway</str><city>Cambridge, Massachusetts 02138</city><ctry>US</ctry></adr></B721><B721><snm>Nguyen, Minh</snm><adr><str>920, 5th Avenue SW, Apt. 1607</str><city>Calgary, Alberta T2P 5P6</city><ctry>US</ctry></adr></B721><B721><snm>Howitz, Konrad</snm><adr><str>1125 N 25th Street</str><city>Allentown, Pennsylvania 18104</city><ctry>US</ctry></adr></B721><B721><snm>Zipkin, Robert</snm><adr><str>1214 Weymouth Road</str><city>Wynnewood, Pennsylvania 19096</city><ctry>US</ctry></adr></B721><B721><snm>Bitterman, Kevin J.</snm><adr><str>58 W. Rutland Square, 1</str><city>Boston, MA 02118</city><ctry>US</ctry></adr></B721></B720><B730><B731><snm>President and Fellows of Harvard College</snm><iid>101121798</iid><irf>N2653 EP/1 S3</irf><adr><str>17 Quincy Street</str><city>Cambridge, MA 02138</city><ctry>US</ctry></adr></B731><B731><snm>Biomol International L.P.</snm><iid>100087853</iid><irf>N2653 EP/1 S3</irf><adr><str>5120 Butler Pike</str><city>Plymouth Meeting, PA 19462-1202</city><ctry>US</ctry></adr></B731></B730><B740><B741><snm>Lee, Nicholas John</snm><sfx>et al</sfx><iid>100036802</iid><adr><str>Kilburn &amp; Strode LLP 
20 Red Lion Street</str><city>London WC1R 4PJ</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IS</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LT</ctry><ctry>LU</ctry><ctry>LV</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>TR</ctry></B840><B880><date>20110831</date><bnum>201135</bnum></B880></B800></SDOBI>
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