(19)

(11)

EP 2 362 909 A2

(12)

(88) Date of publication A3: 16.09.2010 (43) Date of publication: 07.09.2011 Bulletin 2011/36 (21) Application number: 09818408.8 (22) Date of filing: 30.09.2009

(51) International Patent Classification (IPC):  C12N 15/63(2006.01) C12Q 1/68(2006.01) C12N 15/33(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/US2009/058947 (87) International publication number: WO 2010/039778 (08.04.2010 Gazette 2010/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 30.09.2008 US 194774 P 09.10.2008 US 195770 P (71) Applicants: Zirus, Inc. Buford, GA 30518-9206 (US) Vanderbilt University Nashville, Tennessee 37240 (US)	(72) Inventors: RUBIN, Donald Nashville TN 37215-4133 (US) HODGE, Thomas Athens GA 30606 (US) MURRAY, James Bogart GA 30622 (US) MCDONALD, Natalie Atlanta GA 30319-3929 (US) (74) Representative: Leissler-Gerstl, Gabriele  Hoefer & Partner Patentanwälte Pilgersheimer Strasse 20 81543 München 81543 München (DE)