Elastase for opening obstructed biological conduits

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EP 2 363 142 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	10.06.2015 Bulletin 2015/24

(45)	Mention of the grant of the patent:
	25.03.2015 Bulletin 2015/13

(21)	Application number: 10180533.1

(22)	Date of filing: 24.09.2000

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International Patent Classification (IPC):

A61K 38/48^(2006.01)
A61K 31/00^(2006.01)

A61K 38/55^(2006.01)
A61K 31/167^(2006.01)

(54)	Elastase for opening obstructed biological conduits Elastase zum Öffnen verstopfter biologischer Kanäle Élastase pour ouvrir des conduits biologiques obturés

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

24.09.1999 US 155938 P

(43)	Date of publication of application:
	07.09.2011 Bulletin 2011/36

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	07008805.9 / 1923068
	00965396.5 / 1220830

(73)	Proprietor: Proteon Therapeutics, Inc.
	Waltham, MA 02451 (US)

(72)	Inventor:
	Franano, Nicholas F. Laurel, MD 20723 (US)

(74)	Representative: Adam, Holger
	Kraus & Weisert Patentanwälte PartGmbB Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)

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References cited: :

US-A- 5 116 615
US-A- 5 834 449

US-A- 5 318 531

DATABASE WPI Week 199018 Thomson Scientific, London, GB; AN 1990-137116 XP002652809, & JP 2 086777 A (SANKYO CO LTD) 27 March 1990 (1990-03-27)
KERENYI T ET AL: "LOCAL ENZYMATIC TREATMENT OF ATHEROSCLEROTIC PLAQUES", EXPERIMENTAL AND MOLECULAR PATHOLOGY, ACADEMIC PRESS, US, vol. 49, no. 3, 1 January 1988 (1988-01-01), pages 330-338, XP002430756, ISSN: 0014-4800, DOI: 10.1016/0014-4800(88)90005-6
AKIMOTO FUMIKAZU: "The effect of pancreatopeptidase E (Elastase) on anastomotic intimal thickness in two types of vascular prosthesis", SURGERY TODAY,, vol. 25, no. 12, 1 January 1995 (1995-01-01), pages 1027-1033, XP009121339, DOI: DOI:10.1007/BF00311687
FUJIOKA K; ESATO K; ZEMPO N: "Effect of elastase on primary graft patency after femoralpopliteal arterial bypass for arteriosclerosis obliterans: a randomized, controlled study.", INTERNATIONAL SURGERY 1997 JAN-MAR LNKD- PUBMED:9189814, vol. 82, no. 1, January 1997 (1997-01), pages 94-97, XP9150609, ISSN: 0020-8868
OOYAMA TOSHIRO; SAKAMATO HIROSHI: "Elastase in the prevention of arterial ageing and the treatment of atherosclerosis", CIBA FOUNDATION SYMPOSIUM; THE MOLECULAR BIOLOGY AND PATHOLOGY OF ELASTIC TISSUES JOHN WILEY AND SONS LTD., BAFFIN LANE, CHICHESTER PO 19 1UD, ENGLAND; JOHN WILEY AND SONS, INC., 605 THIRD AVENUE, NEW YORK, NEW YORK 10158-0012, USA SERIES : CIBA FOUN, 1995, pages 307-317, XP009150607, SYMPOSIUM; NAIROBI, KENYA; NOVEMBER 1-3, 1994

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