| (19) |
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(11) |
EP 2 365 065 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
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Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
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Corrected version no 1 (W1 A2) |
| (48) |
Corrigendum issued on: |
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23.11.2011 Bulletin 2011/47 |
| (43) |
Date of publication: |
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14.09.2011 Bulletin 2011/37 |
| (22) |
Date of filing: 03.10.2006 |
| (27) |
Previously filed application:
03.10.2006 PCT/IB20/06003883 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
| (30) |
Priority: |
25.10.2005 WO PCT/IB2005/003564
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| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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06842325.0 / 1954807 |
| (71) |
Applicant: Cellectis |
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93235 Romainville Cedex (FR) |
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| (72) |
Inventor: |
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- Paques, Frédéric
92340 Bourg-La-Reine (FR)
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| (74) |
Representative: Noel, Chantal Odile et al |
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Cabinet Orès
36, rue de St Pétersbourg
75008 Paris
75008 Paris (FR) |
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Remarks: |
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Claims filed after the date of receipt of the divisional application (Rule 68(4) EPC). |
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Remarks: |
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This application was filed on 30-09-2010 as a divisional application to the application
mentioned under INID code 62. |
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| (54) |
I-Crel homing endonuclease variants having novel cleavage specificity and use thereof |
(57) A method for engineering I-
CreI homing endonuclease variants able to cleave mutant I-
CreI sites having variation in positions ± 8 to ±10. A I-
CreI homing endonuclease variant obtainable by said method, a vector encoding said variant,
a cell, an animal or a plant modified by said vector. Use of said I-
CreI endonuclease variant and derived products for genetic engineering, genome therapy
and antiviral therapy.