(19)
(11) EP 2 369 017 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
12.03.2014 Bulletin 2014/11

(45) Mention of the grant of the patent:
04.12.2013 Bulletin 2013/49

(21) Application number: 11170608.1

(22) Date of filing: 12.07.2007
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)

(54)

Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases

Verfahren und Zusammensetzungen auf Mikro-RNA-Basis zur Diagnose und Behandlung von Krankheiten im Zusammenhang mit dem Dickdarm

Procédés basés sur le micro-ARN et compositions pour le diagnostic et le traitement de maladies liées au côlon


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 13.07.2006 US 807304 P
01.06.2007 US 932736 P

(43) Date of publication of application:
28.09.2011 Bulletin 2011/39

(60) Divisional application:
11196190.0 / 2455492
11196250.2 / 2455493
11196253.6 / 2455494
11196254.4 / 2436782
11196256.9 / 2436783
11196261.9 / 2436784
11196262.7 / 2436785
11196264.3 / 2436786
11196265.0 / 2436787

(62) Application number of the earlier application in accordance with Art. 76 EPC:
07810382.7 / 2041317

(73) Proprietors:
  • The Ohio State University Research Foundation
    Columbus, OH 43201 (US)
  • The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services
    Rockville, MD 20852-3804 (US)

(72) Inventors:
  • Croce, Carlo
    Columbus, OH 43221 (US)
  • Harris, Curtis
    Garrett Part, MD 20896-0077 (US)
  • Schetter, Aaron
    Rockville, MD 20852 (US)

(74) Representative: Turner, Craig Robert 
A.A. Thornton & Co. 235 High Holborn
London WC1V 7LE
London WC1V 7LE (GB)


(56) References cited: : 
WO-A2-2005/094263
WO-A2-2007/081740
   
  • BANDRÉS E ET AL: "Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 5, 19 July 2006 (2006-07-19), page 29, XP002460700, ISSN: 1476-4598, DOI: 10.1186/1476-4598-5-29
  • SCHETTER AARON J ET AL: "MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 299, no. 4, 30 January 2008 (2008-01-30), pages 425-436, XP002529936, ISSN: 0098-7484, DOI: 10.1001/JAMA.299.4.425
  • SCHETTER A J ET AL: "Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 15, no. 18, 15 September 2009 (2009-09-15), pages 5878-5887, XP002565705, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-09-0627 [retrieved on 2009-09-08]
  • SLABY O ET AL: "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer", ONCOLOGY, S. KARGER, BASEL, CH, vol. 72, no. 5-6, 1 December 2007 (2007-12-01), pages 397-402, XP009111358, ISSN: 0030-2414, DOI: 10.1159/000113489 [retrieved on 2008-01-15]
  • VOLINIA STEFANO ET AL: "A microRNA expression signature of human solid tumors defines cancer gene targets", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 103, no. 7, 14 February 2006 (2006-02-14), pages 2257-2261, XP002460699, ISSN: 0027-8424
  • MICHAEL M Z ET AL: "REDUCED ACCUMULATION OF SPECIFIC MICRORNAS IN COLORECTAL NEOPLASIA", MOLECULAR CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH (A AC R), US, vol. 1, no. 12, 1 October 2003 (2003-10-01), pages 882-891, XP009051992, ISSN: 1541-7786
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).