(19)
(11) EP 2 370 434 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.10.2014 Bulletin 2014/42

(45) Mention of the grant of the patent:
17.09.2014 Bulletin 2014/38

(21) Application number: 09775524.3

(22) Date of filing: 22.12.2009
(51) International Patent Classification (IPC): 
C07D 455/03(2006.01)
A61K 31/4741(2006.01)
 C07D 495/04(2006.01)
A61P 3/06(2006.01)
(86) International application number:
PCT/US2009/069331
(87) International publication number:
WO 2010/075469 (01.07.2010 Gazette 2010/26)

(54)

ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS

ZUR REDUZIERUNG VON FETTSPIEGELN GEEIGNETE ISOCHINOLIN-ENTHALTENDEN ALKALOIDDERIVATE UND DEREN ZUSAMMENSETZUNGEN

DÉRIVÉS ALCALOÏDES CONTENANT UN ISOQUINOLINE ET LEUR COMPOSITIONS, UTILES DANS LA RÉDUCTION DES TAUX LIPIDIQUES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 23.12.2008 US 140551 P

(43) Date of publication of application:
05.10.2011 Bulletin 2011/40

(73) Proprietor: CVI Pharmaceuticals Limited
Grand Cayman KY1-1112 (KY)

(72) Inventors:
  • LIU, Haiyan
    Grand Cayman KY1-1112 (KY)
  • LI, Gaoping
    Grand Cayman KY1-1112 (KY)
  • WANG, Junbo
    Grand Cayman KY1-1112 (KY)
  • LIU, Jingwen
    Grand Cayman KY1-1112 (KY)

(74) Representative: Potter Clarkson LLP 
The Belgrave Centre Talbot Street
Nottingham, NG1 5GG
Nottingham, NG1 5GG (GB)


(56) References cited: : 
WO-A1-2009/002873
US-A1- 2008 124 404
 US-A- 4 645 772
   
  • GEORGES MEMETZIDIS ET AL: "Synthesis of Aromatic Chloroberbines" HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 31, no. 3, 1 February 1990 (1990-02-01), pages 341-351, XP009126816 ISSN: 0385-5414
  • MEMETZIDIS G ET AL: "Structure-affinity relationships of berbines or 5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quino lizines at alpha-adrenoceptors" EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 26, no. 6, 1 September 1991 (1991-09-01), pages 605-611, XP023870507 ISSN: 0223-5234 [retrieved on 1991-09-01]
  • STAMBACH, J-F. ET AL.: "Phosgenation of benzyltetrahydroisoquinolines" TETRAHEDRON, vol. 41, no. 1, 1 January 1985 (1985-01-01), pages 169-172, XP002571328
  • CHINNASAMY, P. ET AL.: "3,10-Dimethoxyprotoberberines." ARCH. PHARM., vol. 320, 1 January 1987 (1987-01-01), pages 790-798, XP002571329
  • STAMBACH, J-F. ET AL.: "Selective acetylation of berbin-8-one. Synthesis of 2-methoxyberbine." HETEROCYCLES, vol. 36, no. 4, 1 January 1993 (1993-01-01), pages 819-824, XP009130147
  • NAGATA, W. ET AL.: "Synthetic studies on isoquinoline alkaloids. II. Selective conversion of 3,9,10-substituted tetrahydroprotoberberines into 3,9,10-substituted 14-deoxoprotopines. Total synthesis of 3,9,10-substituted 5,6,7,8,13,14-hexahydrodibenz[c,g]azecines " CHEM. PHARM. BULL., vol. 23, 1 January 1975 (1975-01-01), pages 2878-2890, XP002571331
  • DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 January 1963 (1963-01-01), TAKEMOTO, TSUNEMATSU ET AL: "Reactions of protoberberine-type alkaloids. I. Reaction of dihydroberberine with alkyl halides" XP002571332 retrieved from STN Database accession no. 1963:403686 & TAKEMOTO, TSUNEMATSU ET AL: "Reactions of protoberberine-type alkaloids. I. Reaction of dihydroberberine with alkyl halides" YAKUGAKU ZASSHI , 82, 1408-13 CODEN: YKKZAJ; ISSN: 0031-6903, 1962,
  • DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 January 1959 (1959-01-01), BLANCHARD, WESLEY A.: "Synthesis of the necines related to the Senecio alkaloids" XP002571333 retrieved from STN Database accession no. 1959:89579 & BLANCHARD, WESLEY A.: "Synthesis of the necines related to the Senecio alkaloids" 66 PP. AVAIL.: UNIV. MICROFILMS (ANN ARBOR, MICH.) FROM: DISSERTATION ABSTR. 19, 2461-2, 1959,
   
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