(19)
(11) EP 2 370 466 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.06.2015 Bulletin 2015/26

(45) Mention of the grant of the patent:
06.05.2015 Bulletin 2015/19

(21) Application number: 09795723.7

(22) Date of filing: 21.12.2009
(51) International Patent Classification (IPC): 
C07K 16/18(2006.01)
(86) International application number:
PCT/EP2009/009186
(87) International publication number:
WO 2010/069603 (24.06.2010 Gazette 2010/25)

(54)

HUMAN ANTI-ALPHA-SYNUCLEIN AUTOANTIBODIES

MENSCHLICHE ANTI-ALPHA-SYNUCLEIN-AUTOANTIKÖRPER

AUTO-ANTICORPS HUMAINS ANTI-ALPHA-SYNUCLÉINE


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated Extension States:
AL BA RS

(30) Priority: 19.12.2008 EP 08022188
19.12.2008 US 139253 P

(43) Date of publication of application:
05.10.2011 Bulletin 2011/40

(60) Divisional application:
15166032.1

(73) Proprietors:
  • Biogen International Neuroscience GmbH
    6300 Zug (CH)
  • University of Zurich
    8006 Zurich (CH)

(72) Inventors:
  • WEIHOFEN, Andreas
    CH-8037 Zurich (CH)
  • GRIMM, Jan
    CH-8600 Dübendorf (CH)
  • NITSCH, Roger
    CH-8126 Zumikon (CH)
  • HOCK, Christoph
    CH-8703 Erlenbach (CH)

(74) Representative: Steinecke, Peter 
Müller Fottner Steinecke Rechtsanwalts- und Patentanwaltspartnerschaft mbB Römerstrasse 16 b
52428 Jülich
52428 Jülich (DE)


(56) References cited: : 
   
  • NEFF FRAUKE ET AL: "Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders." AUTOIMMUNITY REVIEWS JUN 2008, vol. 7, no. 6, June 2008 (2008-06), pages 501-507, XP022732412 ISSN: 1568-9972
  • PAPACHRONI KATERINA K ET AL: "Autoantibodies to alpha-synuclein in inherited Parkinson's disease." JOURNAL OF NEUROCHEMISTRY MAY 2007, vol. 101, no. 3, May 2007 (2007-05), pages 749-756, XP002530228 ISSN: 0022-3042
  • EMADI ET AL: "Isolation of a Human Single Chain Antibody Fragment Against Oligomeric alpha-Synuclein that Inhibits Aggregation and Prevents alpha-Synuclein-induced Toxicity" JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 368, no. 4, 17 April 2007 (2007-04-17), pages 1132-1144, XP022030022 ISSN: 0022-2836
  • LYNCH ET AL: "An scFv Intrabody against the Nonamyloid Component of alpha-Synuclein Reduces Intracellular Aggregation and Toxicity" JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 377, no. 1, 5 December 2007 (2007-12-05), pages 136-147, XP022501449 ISSN: 0022-2836
  • EMADI SHARAREH ET AL: "Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments" BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA.; US, vol. 43, no. 10, 16 March 2004 (2004-03-16), pages 2871-2878, XP002517647 ISSN: 0006-2960 [retrieved on 2004-02-20]
  • ELISA A WAXMAN ET AL: "Characterization of antibodies that selectively detect Î+--synuclein in pathological inclusions" ACTA NEUROPATHOLOGICA, SPRINGER, BERLIN, DE, vol. 116, no. 1, 15 April 2008 (2008-04-15), pages 37-46, XP019628809 ISSN: 1432-0533
  • GIASSON B I ET AL: "A Panel of Epitope-Specific Antibodies Detects Protein Domains Distributed Throughout Human alpha-Synuclein in Lewy Bodies of Parkinson's Disease" JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 59, 1 February 2000 (2000-02-01), pages 528-533, XP003016506 ISSN: 0360-4012
  • ZHANG L ET AL: "Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody" BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1244, 9 December 2008 (2008-12-09), pages 40-52, XP025679551 ISSN: 0006-8993 [retrieved on 2008-09-04]
  • LIPPA C F ET AL: "ANTIBODIES TO ALPHA-SYNUCLEIN DETECT LEWY BODIES IN MANY DOWN'S SYNDROME BRAINS WITH ALZHEIMER'S DISEASE" ANNALS OF NEUROLOGY, JOHN WILEY AND SONS, BOSTON, US, vol. 45, no. 3, 1 March 1999 (1999-03-01), pages 353-357, XP008074304 ISSN: 0364-5134
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).