(19)
(11) EP 2 376 480 A2

(12)

(88) Date of publication A3:
16.09.2010

(43) Date of publication:
19.10.2011 Bulletin 2011/42

(21) Application number: 09795606.4

(22) Date of filing: 04.12.2009
(51) International Patent Classification (IPC): 
C07D 405/12(2006.01)
A61P 35/00(2006.01)
 A61K 31/404(2006.01)
(86) International application number:
PCT/US2009/066790
(87) International publication number:
WO 2010/065865 (10.06.2010 Gazette 2010/23)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated Extension States:
AL BA RS

(30) Priority: 05.12.2008 US 120275 P
26.05.2009 US 181180 P

(71) Applicant: Abbott Laboratories
Abbott Park, Illinois 60064 (US)

(72) Inventors:
  • BRUNCKO, Milan
    Green Oaks IL 60048 (US)
  • DING, Hong
    Gurnee IL 60031 (US)
  • DOHERTY, George, A.
    Libertyville IL 60048 (US)
  • ELMORE, Steven, W.
    Northbrook IL 60062 (US)
  • HASVOLD, Lisa
    Grayslake IL 60030 (US)
  • HEXAMER, Laura
    Grayslake IL 60030 (US)
  • KUNZER, Aaron, R.
    Schaumburg IL 60193-2287 (US)
  • MANTEI, Robert, A.
    Franklin WI 53132 (US)
  • MCCLELLAN, William, J.
    Waukegan IL 60085 (US)
  • PARK, Chang, H.
    Wadsworth IL 60083 (US)
  • PARK, Cheol-min
    Gurnee IL 60031 (US)
  • PETROS, Andrew, M.
    Mundelein IL 60060 (US)
  • SONG, Xiaohong
    Grayslake IL 60030 (US)
  • SOUERS, Andrew, J.
    Evanston IL 60202 (US)
  • SULLIVAN, Gerard, M.
    Lake Villa IL 60046 (US)
  • TAO, Zhi-fu
    Gurnee IL 60031 (US)
  • WANG, Gary, T.
    Libertyville IL 60048 (US)
  • WANG, Le
    Vernon Hills IL 60061 (US)
  • WANG, Xilu
    Grayslake IL 60030 (US)
  • WENDT, Michael, D.
    Vernon Hills IL 60061 (US)

(74) Representative: Modiano, Micaela Nadia et al
Modiano & Partners Thierschstrasse 11
80538 München
80538 München (DE)

   


(54) SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES