(19)

(11)

EP 2 379 596 A1

(12)

(43) Date of publication: 26.10.2011 Bulletin 2011/43 (21) Application number: 09796383.9 (22) Date of filing: 21.12.2009

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/EP2009/067707 (87) International publication number: WO 2010/072741 (01.07.2010 Gazette 2010/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 23.12.2008 US 140336 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)

(72) Inventors: BARRY, Simon Thomas Rudyard Staffordshire ST13 8RG (GB) EBERLEIN, Catherine Anne Altrincham Cheshire WA15 8HY (GB) FOLTZ, Ian Burnaby British Columbia V5A 4BP (CA) KANG, Paul Burnaby, British Columbia V5A 1V7 (CA) KENDREW, Jane Wilmslow Cheshire SK9 5PW (GB) ALFRED, Avril Chilliwack British Columbia V2R 5W4 (CA) (74) Representative: Myers, Jonathan David  MedImmune Ltd. Milstein Building Granta Park Cambridge CB21 6GH Cambridge CB21 6GH (GB)