(19)
(11) EP 2 402 037 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.12.2019 Bulletin 2019/49

(45) Mention of the grant of the patent:
23.10.2019 Bulletin 2019/43

(21) Application number: 11172570.1

(22) Date of filing: 24.05.2007
(51) International Patent Classification (IPC): 
A61K 47/50(2017.01)
 A61P 25/04(2006.01)

(54)

CONTROLLED RELEASE OF PHENOLIC OPIOIDS

Kontrollierte Freisetzung phenolischer Opioide

Libération contrôlée d'opioïdes phénoliques

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
Designated Extension States:
AL BA HR MK RS

(30) Priority: 26.05.2006 US 809082 P
16.02.2007 US 901795 P

(43) Date of publication of application:
04.01.2012 Bulletin 2012/01

(62) Application number of the earlier application in accordance with Art. 76 EPC:
07797745.2 / 2046393

(73) Proprietor: Signature Therapeutics, Inc.
La Jolla, CA 92037 (US)

(72) Inventors:
  • Jenkins, Thomas E
    Half Moon Bay, CA 94019 (US)
  • Kolesnikov, Aleksandr
    San Francisco, CA 94121 (US)

(74) Representative: Mewburn Ellis LLP 
City Tower 40 Basinghall Street
London EC2V 5DE
London EC2V 5DE (GB)


(56) References cited: : 
WO-A2-03/072046
 US-A1- 2004 063 628
   
  • GROOT DE F M H ET AL: "Synthesis and Biological Evaluation of 2'-Carbamate-Linked and 2'-Carbonate-Linked Prodrugs of Paclitaxel: Selective Activation by the Tumor-Associated Protease Plasmin", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43, 1 January 2000 (2000-01-01), pages 3093-3102, XP002212034, ISSN: 0022-2623, DOI: 10.1021/JM0009078
  • SAARI W S ET AL: "CYCLIZATION-ACTIVATED PRODRUGS. BASIC CARBAMATES OF 4-HYDROXYANISOLE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, 1 January 1990 (1990-01-01), pages 97-101, XP001120293, ISSN: 0022-2623, DOI: 10.1021/JM00163A016
  • GROOT DE FRANCISCUS M H ET AL: "Elongated Multiple Electronic Cascade and Cyclization Spacer Systems in Activatible Anticancer Prodrugs for Enhanced Drug Release", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 66, 1 January 2001 (2001-01-01), pages 8815-8830, XP002212035, ISSN: 0022-3263, DOI: 10.1021/JO0158884
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).