(19)

(11)

EP 2 403 494 A2

(12)

(88) Date of publication A3: 13.01.2011 (43) Date of publication: 11.01.2012 Bulletin 2012/02 (21) Application number: 10749320.7 (22) Date of filing: 04.03.2010

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/54(2006.01) A61K 31/40(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2010/026184 (87) International publication number: WO 2010/102095 (10.09.2010 Gazette 2010/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 06.03.2009 US 209431 P (71) Applicant: University of Florida Research Foundation, Inc. Gainesville, Florida 32611-5500 (US)	(72) Inventors: GOLUBOVSKAYA, Vita Orchard Park, NY 14127 (US) OSTROV, David, A. Gainesville, FL 32607 (US) CANCE, William, G. Buffalo, NY 14263 (US) (74) Representative: Maschio, Antonio  Edwards Wildman Innovations LLP 10 Carlton Crescent Southampton SO15 2EZ Southampton SO15 2EZ (GB)