8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS - Patent 2403833

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(11)

EP 2 403 833 A1

(12)

(43)	Date of publication:
	11.01.2012 Bulletin 2012/02

(21)	Application number: 10749227.4

(22)	Date of filing: 02.03.2010

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International Patent Classification (IPC):

C07D 215/48^(2006.01)
C07D 401/12^(2006.01)
A61K 31/5377^(2006.01)
A61K 31/47^(2006.01)
C07D 413/14^(2006.01)
A61P 3/00^(2006.01)
A61K 31/497^(2006.01)
C07D 417/14^(2006.01)
A61P 9/00^(2006.01)
A61K 31/506^(2006.01)

A61K 31/519^(2006.01)
A61K 31/4375^(2006.01)
C07D 401/14^(2006.01)
A61K 31/538^(2006.01)
A61K 31/4709^(2006.01)
C07D 417/12^(2006.01)
A61P 5/50^(2006.01)
A61K 31/501^(2006.01)
C07D 487/04^(2006.01)
A61P 35/02^(2006.01)

(86)	International application number:
	PCT/US2010/025963

(87)	International publication number:
	WO 2010/101949 (10.09.2010 Gazette 2010/36)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
	Designated Extension States:
	AL BA ME RS

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Priority:

02.03.2009 US 156749 P

(71)	Applicant: Sirtris Pharmaceuticals, Inc.
	Cambridge, MA 02139 (US)

(72)	Inventors:
	VU, Chi, B. Cambridge, MA 02139 (US) CASAUBON, Rebecca, L. Cambridge, MA 02139 (US)

(74)	Representative: Valentine, Jill Barbara
	GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)

(54)	8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS