(19)

(11)

EP 2 406 628 A1

(12)

(43) Date of publication: 18.01.2012 Bulletin 2012/03 (21) Application number: 10709198.5 (22) Date of filing: 11.03.2010

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) (86) International application number: PCT/EP2010/053063 (87) International publication number: WO 2010/103058 (16.09.2010 Gazette 2010/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA ME RS (30) Priority: 12.03.2009 EP 09154964 (71) Applicant: Boehringer Ingelheim International GmbH 55216 Ingelheim am Rhein (DE)	(72) Inventors: ARAO, Tokuzo Osaka-Sayama Osaka 589-8511 (JP) KUDO, Kanae Osaka-Sayama Osaka 589-8511 (JP) NAKAGAWA, Kazuhiko Osaka-Sayama Osaka 589-8511 (JP) NISHIO, Kazuto Osaka-Sayama Osaka 589-8511 (JP) (74) Representative: Hammann, Heinz  Boehringer Ingelheim GmbH Corporate Patents Binger Strasse 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)