Processes and intermediates for preparing steric compounds

(19)

(11)

EP 2 407 448 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	25.07.2012 Bulletin 2012/30

(43)	Date of publication A2:
	18.01.2012 Bulletin 2012/03

(21)	Application number: 11172239.3

(22)	Date of filing: 14.03.2007

(51)

International Patent Classification (IPC):

C07C 231/20^(2006.01)
C07C 231/12^(2006.01)
C07C 59/255^(2006.01)
C07D 303/48^(2006.01)

C07C 237/04^(2006.01)
C07C 247/04^(2006.01)
C07C 41/00^(2006.01)
C07J 41/00^(2006.01)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30)

Priority:

15.09.2006 US 844771 P
16.03.2006 US 782976 P

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	07752981.6 / 1993993

(71)	Applicant: VERTEX PHARMACEUTICALS INCORPORATED
	Cambridge, MA 02139-4242 (US)

(72)	Inventors:
	Tanoury, Gerald J. Hudson, MA 01749 (US) Chen, Minzhang Acton, MA 01720 (US) Jung, Young Chun Lexington, MA 02420 (US) Forslund, Raymond E. Natick, MA 01760 (US)

(74)	Representative: Cohausz & Florack
	Patent- und Rechtsanwälte Partnerschaftsgesellschaft Bleichstraße 14 40211 Düsseldorf 40211 Düsseldorf (DE)

(54)	Processes and intermediates for preparing steric compounds

(57) This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula (1) wherein the variables R₁, R₁' and R₂ are defined herein and the compound of Formula (1) has an enantiomeric excess (ee) of 55 % or greater.

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