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(11)

EP 2 408 435 A2

(12)

(88) Date of publication A3: 13.01.2011 (43) Date of publication: 25.01.2012 Bulletin 2012/04 (21) Application number: 10753982.7 (22) Date of filing: 16.03.2010

(51) International Patent Classification (IPC):  A61K 9/22(2006.01) A61K 31/722(2006.01) C08L 5/08(2006.01) A61K 9/20(2006.01) A61P 17/02(2006.01) (86) International application number: PCT/US2010/027481 (87) International publication number: WO 2010/107794 (23.09.2010 Gazette 2010/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 16.03.2009 US 160539 P 22.07.2009 US 227606 P 22.04.2009 US 171805 P (71) Applicant: University Of Memphis Research Foundation Memphis, Tennessee 38152 (US)	(72) Inventors: HAGGARD, Warren, O. Bartlett TN 38135 (US) NOEL, Scott, P. Arlington TN 38002 (US) BUMGARDNER, Joel, D. Memphis TN 38104 (US) (74) Representative: Adam, Holger  Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)