Technical Field
[0001] This invention relates to a pharmaceutical composition container; more specifically,
to a pharmaceutical composition container so configured as to allow the reduction
of the residual quantity of the pharmaceutical composition.
Background Art
[0002] In general, when ingesting a pharmaceutical composition like a powdered or granular
preparation, the pharmaceutical composition is swallowed using water. However, since
this pharmaceutical composition is swallowed by drinking water after having the pharmaceutical
composition received on the tongue, there are problems such as that a part of the
pharmaceutical composition stays inside the mouth for a long time, that there is irritation
from the pharmaceutical ingredients, or that it is not possible to ingest the pharmaceutical
composition while lying down, since the pharmaceutical composition is ingested with
water, which is highly fluid.
[0003] Patent document 1 discloses a multi-chamber container. This multi-chamber container
is so partitioned into a plurality of spaces as to enable the spaces to be interconnected
with each other. The spaces are sealed in such a state that they can be interconnected
with each other by means of force applied from the outside. A granular agent is stored
in a tightly sealed state in any of the spaces. A thick fluid substance is stored
in a tightly sealed state in one or more other spaces. After interconnecting the spaces
with each other and gathering and mixing the granular agent with the thick fluid substance,
it is possible to take out the mixture from a take-out port provided on any of the
spaces.
[0004] According to the container disclosed in patent document 1, it is possible to ingest
a granular agent by means of an extremely simple operation. Moreover, according to
the multi-chamber container disclosed in patent document 1, it is possible to significantly
reduce the resistance of the patient towards taking the medication.
Prior art documents
Patent documents
[0005]
Patent document 1: Japanese Patent Laid-Open No. 10-234820
Brief Summary of the Invention
Problem to Be Solved By the Invention
[0006] However, with the invention disclosed in patent document 1, there is the problem
that, when the pharmaceutical composition is a powder, a powdered preparation or a
granular preparation, it is highly probable that there are residues in the multi-chamber
container.
[0007] The technical issue addressed by this invention was drafted to solve the abovementioned
problem, and the purpose of the invention is to provide a pharmaceutical composition
container that allows the reduction of the residual quantity of the pharmaceutical
composition.
Means for Solving the Problem
[0008] The pharmaceutical composition container of this invention is explained in reference
to the drawings. Note that the use of the reference numerals of the drawings in this
column is intended to facilitate the understanding of the content of the invention
and is not intended to limit the content to the scope indicated.
[0009] According to the aspects of this invention in order to achieve the abovementioned
purpose, the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) are
equipped with a plurality of spaces (30, 32, 34, 36, 38, 100, 102, 104, 106, 110,
112, 114, 116, 150). The portions (70, 72, 76) between two adjoining spaces are sealed.
The portions (70, 72, 76) between two adjoining spaces open when force is applied
from the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15,
16, 18). A swallowing-aid substance (40) is stored in swallowing-aid substance storing
chambers (30, 100, 102, 104, 106) which are at least one of the spaces. Encapsulating
items (42, 120) are stored in encapsulating-item storing chambers (32, 110, 112, 114)
which each are at least one of the spaces. The encapsulating items (42, 120) contain
the pharmaceutical composition (80) . At least the surface of the encapsulating items
(42, 120) melts in the ingredients of the swallowing-aid substance (40). The pharmaceutical
composition containers (10, 11, 12, 14, 15, 16, 18) are provided with a predetermined
aperture part (60) . The predetermined aperture part (60) is a portion where an aperture
is to be formed. The aperture interconnects the outside of the pharmaceutical composition
containers (10, 11, 12, 14, 15, 16, 18) with the spaces (30, 32, 34, 36, 38, 100,
102, 104, 106, 110, 112, 114, 116, 150).
[0010] The portions (70, 71, 72, 76) between two adjoining spaces are sealed. The portions
(70, 71, 72, 76) between two adjoining spaces open when force is applied from the
outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18)
. By the opening of the portions (70, 71, 72, 76) between two adjoining spaces, it
is possible to guide the swallowing-aid substance (40) from the swallowing-aid substance
storage chambers (30, 100, 102, 104, 106) to the encapsulating-item storage chambers
(32, 110, 112, 114) . Thereby, when holding, after the aperture is formed on the predetermined
aperture part (60), that aperture against the mouth of a person with swallowing difficulties
and pushing out the swallowing-aid substance (40) and the encapsulating items (42,
120) from that aperture, the encapsulating items (42, 120) will enter the mouth of
the person with swallowing difficulties while being enclosed in swallowing-aid substance
(40). The encapsulating items (42, 120) are swallowed. Since the pharmaceutical composition
(80) is inside the encapsulating items (42, 120), the pharmaceutical composition (80)
inside the encapsulating items (42, 120) is pushed out at the same time when the encapsulating
items (42, 120) are pushed out. As a result, the residual quantity of the pharmaceutical
composition (80) in the encapsulating-item storage chambers (32, 110, 112, 114) is
reduced as compared to the case where the pharmaceutical composition is not inside
the encapsulating items (42, 120) . When at least the surface of the encapsulating
items (42, 120) melts in the ingredients of the swallowing-aid substance (40), the
surface of the encapsulating items (42, 120) will melt after the swallowing-aid substance
(40) is guided into the encapsulating-item storage chambers (32, 110, 112, 114). The
encapsulating items (42, 120) can easily be swallowed even by a person with swallowing
difficulties because the encapsulating items (42, 120) are enclosed in the swallowing-aid
substance (40) and the surface of encapsulating items (42, 120) has melted. That being
the case, the pharmaceutical composition (80) is also swallowed with the swallowing
of the encapsulating items (42, 120).
[0011] Further, it is preferable that the abovementioned swallowing-aid substance (40) contain
water. In this case, the material of the encapsulating items (42, 120) is a water-soluble
substance. This reduces the probability that swallowing becomes difficult because
the surfaces of the encapsulating items (42, 120) have not sufficiently melted.
[0012] Or, it is preferable that the abovementioned swallowing-aid substance (40) be a water-containing
jelly. In this case, it is preferable that the water-soluble substance be starch.
[0013] Moreover, it is preferable that a chamber (116), which is at least one of the abovementioned
spaces, is disposed between the swallowing-aid substance storage chamber (102) and
the encapsulating-item storage chamber (114). This is because the provision of a chamber
(116) reduces the probability that the swallowing-aid substance (40) comes into contact
with the encapsulating item (42) when the two adjoining spaces (102, 114) are interconnected
against the will of the user or handler of the pharmaceutical composition container
(15). Reducing that probability also lowers the probability that the encapsulating
item (42) melts before the ingestion of the pharmaceutical composition (80). As a
result, the pharmaceutical composition container (15) will be easy to preserve and
easy to handle.
[0014] Further, it is preferable that the abovementioned encapsulating item (42) be tightly
sealed. Note that "tightly sealed" in this description means being sealed in such
a manner that no gaps exist.
[0015] According to the aspects of this invention, the pharmaceutical composition containers
(210, 260, 400, 500) are equipped with at least three spaces (230, 232, 234, 236,
280, 282, 284, 286, 422, 424, 426, 520, 522, 524, 526). The portions (240, 242, 244,
300, 302, 304, 440, 442, 444, 540, 542, 544) between two adjoining spaces are sealed.
The portions (240, 242, 244, 300, 302, 304, 440, 442, 444, 540, 542, 544) between
two adjoining spaces open when force is applied from the outside of the pharmaceutical
composition containers (210, 260, 400, 500). A swallowing-aid substance (40) is stored
in swallowing-aid substance storage chambers (230, 280, 520) which each are at least
one of the spaces. An encapsulating item (212) is stored in encapsulating-item storage
chambers (232, 234, 282, 284, 422, 424, 522, 524) which each are at least one of the
spaces. The encapsulating item (212) contains the pharmaceutical composition (80).
At least the surface of the encapsulating item (212) melts in the ingredients of the
swallowing-aid substance (40). The aperture chambers (236, 286, 426, 526), which each
are at least one of the spaces, are equipped with an aperture. The aperture interconnects
the outside of the pharmaceutical composition containers (210, 260, 400, 500) with
the spaces (230, 232, 234, 236, 280, 282, 284, 286, 422, 424, 426, 520, 522, 524,
526).
Effect of the Invention
[0016] According to this invention, it is possible to reduce the residual quantity of a
pharmaceutical composition.
Brief Description of the Drawings
[0017]
FIG. 1 is a partial cross section of the pharmaceutical composition container of the
embodiment 1 of this invention.
FIG. 2 shows how the pharmaceutical composition container of the embodiment 1 of this
invention is used.
FIG. 3 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 1 of this invention.
FIG. 4 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 2 of this invention.
FIG. 5 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 3 of this invention.
FIG. 6 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 4 of this invention.
FIG. 7 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 5 of this invention.
FIG. 8 is a partial cross section of the pharmaceutical composition container of the
alternative embodiment 6 of this invention.
FIG. 9 is a partial cross section of the pharmaceutical composition container of the
embodiment 2 of this invention.
FIG. 10 is an external view of the pharmaceutical composition container of the embodiment
2 of this invention.
FIG. 11 shows a state of the embodiment 2 of this invention wherein the cover insert
portion is inserted into the cover and the base is on the outside of the cover.
FIG. 12 is a rear view of the state in the embodiment 2 of this invention wherein
the cover insert portion is inserted into the cover.
FIG. 13 is a partial cross section of the pharmaceutical composition container of
the embodiment 3 of this invention.
FIG. 14 shows the state of the embodiment 3 of this invention wherein the pharmaceutical
composition container is folded.
FIG. 15 shows the state of the embodiment 3 of this invention after one end of the
pharmaceutical composition container is inserted into the cover.
FIG. 16 is a partial cross section of the pharmaceutical composition container of
the embodiment 4 of this invention.
FIG. 17 is a partial cross section showing one end of the pharmaceutical composition
container of the embodiment 4 of this invention during the production thereof.
FIG. 18 is a perspective view showing one end of the pharmaceutical composition container
of the embodiment 4 of this invention during the production thereof.
FIG. 19 is a partial cross section of the pharmaceutical composition container of
the embodiment 5 of this invention.
FIG. 20 shows the wound state of the pharmaceutical composition container of the embodiment
5 of this invention.
Modes for Carrying Out the Invention
[0018] The following explains the embodiments of this invention on the basis of the drawings.
In the following explanations, identical parts are assigned the same reference numeral.
The names and functions thereof are also the same. Accordingly, detailed explanations
thereof will not be repeated.
<Embodiment 1>
[0019] FIG. 1 is a partial cross section of the pharmaceutical composition container 10
of this embodiment. FIG. 2 shows how the pharmaceutical composition container 10 of
this embodiment is used.
[0020] The pharmaceutical composition container 10 of this embodiment is formed by adhering
the peripheries of two synthetic-resin (preferably a soft synthetic resin that can
be folded, such as low-density polyethylene) sheets 20 and 20 to each other. The pharmaceutical
composition 10 has a swallowing-aid substance storage chamber 30, an encapsulating-item
storage chamber 32 and an outlet chamber 34 formed therein. The swallowing-aid substance
chamber 30, the encapsulating-item storage chamber 32 and the outlet chamber 34 are
so formed as to maintain air tightness against the external space. The swallowing-aid
substance storage chamber 30, the encapsulating-item storage chamber 32 and the outlet
chamber 34 are arranged in one row.
[0021] A swallowing-aid substance 40 is stored inside the swallowing-aid substance storage
chamber 30. The swallowing-aid substance 40 in this embodiment is a sterilized jelly
containing water. The water content of the jelly in this embodiment is set in such
a manner that it is possible to provide at least two minutes of time from when the
swallowing-aid substance 40 covers the surface of the encapsulating item 42, which
will be explained later, until the encapsulating item 42 has completely melted. The
outlet chamber 34 is an empty chamber until the second weak seal portion 72, which
will be explained later, is broken.
[0022] An encapsulating item 42 made of a wafer is stored inside the encapsulating-item
storage chamber 32. A granular drug or another pharmaceutical composition 80 is stored
inside the encapsulating item 42. The encapsulating item 42 of this embodiment is
made by placing the pharmaceutical composition 80 into a commercially available wafer
and twisting the portion corresponding to the inlet for the pharmaceutical composition
80. Thereby the encapsulating item 42 is tightly sealed. However, in this embodiment,
a wafer made of starch and having a thickness of 10 µm is used. This is to provide
at least two minutes of time from when the swallowing-aid substance 40 covers the
surface of the encapsulating item 42 until the encapsulating item 42 has completely
melted. Naturally, the thickness of the wafer should be selected as appropriate depending
on the material properties thereof.
[0023] Note that, if necessary, a gas (for example, nitrogen gas) which does not have any
effect on the pharmaceutical composition 80 or the swallowing-aid substance 40 is
filled into the encapsulating-item storage chamber 32 and the swallowing-aid substance
storage chamber 30.
[0024] The portion between the swallowing-aid substance storage chamber 30 and the encapsulating-item
storage chamber 32 is partitioned by a first weak seal portion 70. The portion between
the encapsulating-item storage chamber 32 and the outlet chamber 34 is partitioned
by a second weak seal portion 72. The first weak seal potion 70 and the second weak
seal portion 72 are those parts of the portion where the two sheets 20 and 20 are
adhered to each other which correspond to the portions between two adj oining spaces.
The strength of the first weak seal portion 70 and the second weak seal portion 72
is weaker than the strength of the circumferential strong seal portion 74 (the portion
where the two sheets 20 and 20 are adhered to each other excluding the first weak
seal portion 70 and the second weak seal portion 72). This is made possible by using
different materials as the adhesive agents to adhere the two sheets 20 and 20 to each
other. As a result, the first weak seal portion 70 and the second weak seal portion
72 are easily broken by the force applied by the swallowing-aid substance 40 to the
swallowing-aid substance storage chamber 30 or the encapsulating-item storage chamber
32 when the swallowing-aid substance storage chamber 30 or the encapsulating-item
storage chamber 32 is pressed from the outside of the pharmaceutical composition container
10. That is to say, the swallowing-aid substance storage chamber 30 and the encapsulating-item
storage chamber 32 are sealed in such a state that they can be interconnected with
each other by means of force applied from the outside of pharmaceutical composition
container 10.
[0025] A pair of cutout portions 50, which each comprise a V-shaped cutout, are formed on
the two sides of the outlet chamber 34. The predetermined aperture part 60, which
is sandwiched between the cutout portions 50, is the portion where an aperture is
to be formed. This aperture interconnects the inside of the outlet chamber 34 with
the outside.
[0026] The procedure for taking the pharmaceutical composition 80 out of the pharmaceutical
composition container 10 and ingesting the pharmaceutical composition 80 will be explained
while referring to FIG. 2.
[0027] First, the caretaker etc. presses the swallowing-aid substance storage chamber 30
from the outside of the pharmaceutical composition container 10 to break the first
weak seal portion 70 by means of the pressure from inside the swallowing-aid substance
storage chamber 30. When the first weak seal portion 70 is broken, the swallowing-aid
substance 40 is pushed out into the encapsulating-item storage chamber 32. The swallowing-aid
substance 40 that was pushed out spreads inside of the encapsulating-item storage
chamber 32 and fills the surroundings of the encapsulating item 42. From this time,
the surface of the encapsulating item 42 starts to melt in the swallowing-aid substance
40.
[0028] After the swallowing-aid substance 40 is pushed out into the encapsulating-item storage
chamber 32, the caretaker or patient 90 or the like squeezes the pharmaceutical composition
container 10 from the swallowing-aid substance storage chamber 30 towards the encapsulating-item
storage chamber 32. Thereby, the second weak seal portion 72 breaks as a result from
the pressure applied to the swallowing-aid substance 40. When the second weak seal
portion 72 is broken, the swallowing-aid substance 40 and the encapsulating item 42
are pushed out into the outlet chamber 34. When the swallowing-aid substance 40 and
the encapsulating item 42 are pushed out into the outlet chamber 34, the caretaker
or patient 90 or the like apply a shearing force to the cutouts 50 to form an aperture
on the outlet chamber 34. When the aperture is formed, the caretaker or patient 90
or the like hold that aperture against the mouth of the patient and squeeze the pharmaceutical
composition container 10 from the swallowing-aid substance storage chamber 30 towards
the encapsulating-item storage chamber 32. Thereby the encapsulating item 42, which
is covered by the swallowing-aid substance 40, enters the mouth of the patient 90.
FIG. 2 shows the state in which the patient 90 squeezes the pharmaceutical composition
container 10. At this time, the surface of the encapsulating item 42 has melted in
the ingredients of the swallowing-aid substance 40, and therefore the surface of the
encapsulating item 42 is slippery. Because the surface of the encapsulating item 42
is slippery, the encapsulating item 42 is swallowed smoothly.
[0029] In this way, the pharmaceutical composition container 10 of this embodiment produces
the following effects. The first effect is that it is possible to easily swallow a
granular drug or another pharmaceutical composition 80. The second effect is that
tastes such as the bitter taste of drugs are suppressed. The third effect is that
it is possible to suppress the scattering of the pharmaceutical composition 80 in
the mouth. The fourth effect is that concerns regarding the stability of the drug
become unnecessary. The fifth effect is that it is possible to let patients with swallowing
difficulties ingest solids of various types. The sixth effect is that it is possible
to reduce the residual quantity of the pharmaceutical composition 80 inside the pharmaceutical
composition container 10 (in this embodiment, it is possible to reduce the residual
quantity close to zero).
[0030] The first effect will now be explained in detail. The encapsulating item 42 enters
the mouth of the patient 90 while being covered by the swallowing-aid substance 40.
At this time, the surface of encapsulating item 42 has melted. The encapsulating item
42 can easily be swallowed even by the patient 90, who has swallowing difficulties,
because the encapsulating item 42 is enclosed in the swallowing-aid substance 40 and
the surface of the encapsulating item 42 has melted. Since the pharmaceutical composition
80 is inside the encapsulating item 42, the pharmaceutical composition 80 is also
swallowed with the swallowing of the encapsulating item 42. Thereby it is possible
to easily swallow the pharmaceutical composition 80.
[0031] The second effect will now be explained in detail. As mentioned above, the encapsulating
item 42 enters the mouth of the patient 90 while being covered by the swallowing-aid
substance 40. Thereby the pharmaceutical composition 80, which is contained in the
encapsulating item 42, is doubly enclosed by the swallowing-aid substance 40 and the
encapsulating item 42. Even if the pharmaceutical composition 80 is a drug, the probability
that the tongue of the patient 90 senses the bitter taste thereof is low because the
pharmaceutical composition 80 is doubly enclosed. As a result, the bitter taste or
other tastes of the drugs are suppressed.
[0032] The third effect will now be explained in detail. As mentioned above, the pharmaceutical
composition 80 is doubly enclosed by the swallowing-aid substance 40 and the encapsulating
item 42. This reduces the probability that the pharmaceutical composition 80 scatters
in the mouth of the patient 90. As a result, it is possible to suppress the scattering
of the pharmaceutical composition 80 in the mouth.
[0033] The fourth effect will now be explained in detail. Drugs are chemical substances.
When chemical substances come into contact with each other, chemical reactions occur
in many cases. Due to the occurrence of chemical reactions, the pharmacological effect
of the drug is lost. For this reason, it is not possible to preserve a plurality of
drugs in a mixed state in many cases. If the pharmaceutical compositions are to be
preserved in a mixed state, it is necessary to research in advance whether the chemical
substances lose their pharmacological effect. The pharmaceutical composition container
10 of this embodiment is equipped with a plurality of spaces. Storing one type of
drug each in those spaces is substantially identical with separately preserving a
plurality of drugs. This is the reason why concerns regarding the stability of the
drug are unnecessary when the pharmaceutical composition container 10 of this embodiment
is used. Since concerns regarding the stability of the drug are unnecessary, the advance
research on whether the pharmacological effects of the plurality of drugs are lost
also becomes unnecessary.
[0034] The fifth effect will now be explained in detail. As the swallowing-aid substance
40 and the encapsulating item 42 are swallowed after the swallowing-aid substance
40 is guided into the encapsulating-item storage chamber 32, the activity of the pharmaceutical
composition 80 per se will not have a significant effect on the difficulty or easiness
of swallowing any more. Thereby it is possible to let patients with swallowing difficulties
ingest solids of various types.
[0035] The sixth effect will now be explained in detail. When the swallowing-aid substance
40 and the encapsulating item 42 are pushed out from the aperture formed on the pharmaceutical
composition container 10, the pharmaceutical composition 80 inside the encapsulating
item 42 will also be pushed out at the same time. This significantly reduces the residual
quantity of the pharmaceutical composition 80 in the encapsulating-item storage chamber
32 as compared to cases where the pharmaceutical composition 80 is not contained in
the encapsulating item 42. Moreover, the encapsulating item 42 of this embodiment
is tightly sealed. Since the encapsulating item 42 is tightly sealed, the probability
of the pharmaceutical composition 80 leaking from the encapsulating item 42 is extremely
low. Since this probability is extremely low, it is possible to reduce the residual
quantity of the pharmaceutical composition 80 inside the pharmaceutical composition
container 10 (actually, it is possible to reduce the residual quantity close to zero).
[0036] The pharmaceutical composition container 10 explained in this embodiment is presented
as an example to concretize the technical concept of this invention. The material
properties of the sheet 20 are not limited to the abovementioned embodiment. The shape
of sheet 20, the shape of the spaces, the shape of the aperture, the dimensions, structures
and positioning thereof are not limited to those mentioned in the abovementioned embodiment.
It is possible to apply various changes to the pharmaceutical composition container
10 explained in this embodiment within the scope of the technical concept of this
invention.
[0037] For example, FIG. 3 is a partial cross section of the pharmaceutical composition
container 12 of the alternative embodiment 1. On the swallowing-aid substance storage
chamber 100 in this pharmaceutical composition container 12, a first tapered portion
130, which faces the encapsulating-item storage chamber 110, gradually becomes narrower
towards the encapsulating-item storage chamber 110. On the encapsulating-item storage
chamber 110, a second tapered portion 140, which faces the swallowing-aid substance
storage chamber 100, gradually becomes narrower towards the swallowing-aid substance
storage chamber 100. This increases the probability that, when the first weak seal
portion 70 is broken and the swallowing-aid substance 40 is pushed out into the encapsulating-item
storage chamber 110, the entire quantity of the swallowing-aid substance 40 is pushed
out.
[0038] Further, as an alternative to an encapsulating item 42 like that shown in FIG. 1,
a bag-like encapsulating item 120 like that shown in FIG. 3 may also be stored. Of
course, the encapsulating item 120 may also be stored in the pharmaceutical composition
container 10 shown in FIG. 1. Moreover, the shape of the encapsulating item is not
limited to those shown in FIG. 1 and 3. For example, as an alternative to the encapsulating
items 42 and 120, a publicly known capsule may also be stored as the encapsulating
item. As mentioned above, the swallowing-aid substance 40 in this embodiment is a
sterilized jelly containing water. For this reason, if a publicly known capsule is
stored as the encapsulating item, the surface of that capsule melts in water, which
is an ingredient of the swallowing-aid substance 40. Thereafter the capsule melts
in the digestive juices of the stomach or intestines.
[0039] Further, the number of spaces provided in one pharmaceutical composition container
may be only two, or may be three or more. FIG. 4 is a partial cross section of the
pharmaceutical composition container 14 of the alternative embodiment 2. The pharmaceutical
composition container 14 has a swallowing-aid substance storage chamber 102, a first
encapsulating-item storage chamber 112, a second encapsulating-item storage chamber
114 and an outlet chamber 150 formed therein. The swallowing-aid substance storage
chamber 102, the first encapsulating-item storage chamber 112, the second encapsulating-item
storage chamber 114 and the outlet chamber 150 are arranged in one row. Note that
the end of the first encapsulating-item storage chamber 112 on the side of the second
encapsulating-item storage chamber 114 becomes narrower towards the second encapsulating-item
storage chamber 114, and the encapsulating item 42 is stored in the first encapsulating-item
storage chamber 112; therefore it is possible to smoothly push out the encapsulating
item 42 by means of the swallowing-aid substance 40. The end of the second encapsulating-item
storage chamber 114 on the side of the outlet chamber 150 becomes narrower towards
the outlet chamber 150, and the encapsulating item 42 is stored in the second encapsulating-item
storage chamber 114; therefore this encapsulating item 42 is also pushed out smoothly
in the same way. On a side note, as an alternative to the encapsulating item 42, a
bag-like encapsulating-item 120 like that shown in FIG. 3 may be stored in the first
encapsulating-item storage chamber 112 and the second encapsulating-item storage chamber
114.
[0040] Moreover, an empty chamber may be provided between the swallowing-aid substance storage
chamber and the encapsulating-item storage chamber. An empty chamber is a space in
which nothing is stored, or in which a gas is stored that does not have any effect
on the pharmaceutical composition 80 or the swallowing-aid substance 40. FIG. 5 is
a partial cross section of the pharmaceutical composition container 15 of the alternative
embodiment 3. As an alternative to the first encapsulating-item storage chamber 112
shown in FIG. 4, an empty chamber 116 is provided. Providing an empty chamber 116
can, to a certain extent, reduce the probability that the swallowing-aid substance
40 is mixed with the pharmaceutical composition 80 even if the sealing properties
between the spaces are damaged due to an unintentional accident. If the pharmaceutical
composition container 15 is foldable at the portion of the empty chamber 116, folding
that portion can further reduce the probability that the swallowing-aid substance
40 and the pharmaceutical composition 80 are mixed.
[0041] Further, the pharmaceutical composition container is not limited to one made by adhering
two sheets to each other. FIG. 6 is a partial cross section of the pharmaceutical
composition container 16 of the alternative embodiment 4. FIG. 7 is a partial cross
section of the pharmaceutical composition container 18 of the alternative embodiment
5. The containers are formed by double-folding one sheet. By forming the pharmaceutical
composition containers 16 and 18 by double-folding one sheet for each, it is possible
to increase the volume of the swallowing-aid substance storage chambers 104 and 106
compared to a pharmaceutical composition container formed by adhering two sheets of
the same outer dimensions to each other. When the volume of the swallowing-aid substance
storage chambers 104 and 106 increases, it is possible to increase the feed amount
of the swallowing-aid substance 40. Note that the pharmaceutical composition container
may also be made by adhering the walls of one tube to each other here and there.
[0042] Further, in the abovementioned pharmaceutical composition container, the cutout portions
50 are composed of a V-shaped cutout, but the shape of the cutout in this invention
may be another one than a V-shape.
[0043] Further, in the abovementioned embodiments, cases were explained where the pharmaceutical
composition is a powdered or granular preparation and the swallowing-aid substance
is a jelly; however, it is needless to say that the pharmaceutical composition and
swallowing-aid substance applied to this invention are not limited thereto. For example,
apart from a powdered or granular preparation, the pharmaceutical composition may
be a tablet, a capsule or a simple block. The swallowing-aid substance may be an aqueous
solution, or may also be honey, custard cream, peanut spread, cheese spread or the
like. Moreover, the item formed as the pharmaceutical composition is not limited to
an item that is usually treated as a medical drug. For example, the item formed as
the pharmaceutical composition may also be a food which is recognized for its effect
of improving the health state.
[0044] As the material for the encapsulating item, a wafer made of starch with a thickness
of 10 µm as mentioned above, or a variety of other materials conventionally known
as edible film materials can be used. The types of the materials include polysaccharides
(for example, pullulan, arabinoxylan, decomposition products of guar gum, sodium alginate,
carrageenan, agar-agar, pectin, cellulose etc.) and peptide-based substances (for
example, gelatin, decomposition products of silk protein, decomposition products of
casein etc.). Those materials may be used on a standalone basis or as a combination
of two or more types.
[0045] Further, in the abovementioned embodiment, it was explained that outlet chambers
34 and 150 were provided, however, it is also possible to not provide an outlet chamber
34, but to provide the cutouts 50 on the encapsulating-item storage chamber 32 or
the like, open an aperture by applying shearing force to those cutouts 50 and hold
that aperture against the mouth of the patient.
[0046] Further, the structure of the portions 70, 71 and 72 between two adjoining spaces
may be different than that mentioned above. For example, a thin film may be formed
in the portions 70, 71 and 72 between two adjoining spaces. This kind of film can
be formed by sandwiching the member that serves as the film between the two sheets
20 and 20, and adhering same to each other. However, the structure of the portions
70, 71, and 72 between two adjoining spaces must be a structure that is sealed in
such a state that the spaces are interconnected by a force that is applied from the
outside of the pharmaceutical composition container 10. This "force that is applied
from the outside of the pharmaceutical composition container 10" may be a force that
is directly applied to the portions 70, 71 and 72 between adjoining spaces, or may
be a force that is indirectly applied to any one thereof.
[0047] Further, the swallowing-aid substance 40 does not have to be directly filled into
the space provided in the pharmaceutical composition container. FIG. 8 is a partial
cross section of the pharmaceutical composition container 11 of the alternative embodiment
6. The pharmaceutical composition container 11 of this embodiment has a first bag
storage chamber 36, a second bag storage chamber 38, an encapsulating-item storage
chamber 32 and an outlet chamber 34 formed therein. Same as the encapsulating-item
storage chamber 32 and the outlet chamber 34, the first bag storage chamber 36 and
the second bag storage chamber 38 are so formed as to maintain air tightness against
the external space.
[0048] The first bag storage chamber 36 and the second storage bag chamber 38 store and
fix the aid-substance storage bag 22. The aid-substance storage bag 22 is directly
fixed by the circumferential strong seal portion 74 and the third weak seal portion
76. The strength of the third weak seal portion 76 against breakage is roughly the
same as that of the circumferential strong seal portion 74.
[0049] A swallowing-aid substance 40 is stored inside the aid-substance storage bag 22.
The strength of the aid-substance storage bag 22 on the end at the side facing the
first weak seal portion 70 is such that the end is broken by a force applied from
the outside of the pharmaceutical composition container 11. The swallowing-aid substance
40 is sterilized together with the aid-substance storage bag 22, then sandwiched between
the sheets 20 and 20 and adhered thereto. Next, the outer circumferential strong seal
portion 74 etc. are formed. Thereby one end of the aid-substance storage bag 22 breaks
when force is applied from the outside of the pharmaceutical composition container
11. When the end breaks, the swallowing-aid substance 40 leaks out into the first
bag storage chamber 36. When, at this time, more force is applied from the outside
of the pharmaceutical composition container 11, the first weak seal portion 70 is
broken by the force received from the swallowing-aid substance 40. When the first
weak seal portion 70 is broken, the encapsulating item 42 is enclosed in the swallowing-aid
substance 40.
<Embodiment 2>
[0050] The following explains embodiment 2 of this invention. Note that items which are
identical with those explained in the embodiment 1 are given identical reference numerals.
In this embodiment, the detailed explanation thereof will not be repeated.
<Explanation of the Structure>
[0051] FIG. 9 is a partial cross section of the pharmaceutical composition container 260
of this embodiment. The pharmaceutical composition container 260 of this embodiment
is formed by double-folding one sheet made of a synthetic resin (low-density polyethylene,
PET (polyethylene terephthalate) or another resin that is soft so as to be foldable
and is heat-sealable, like composite resin), adhering the ends of the double-folded
sheet to each other and aligning the outer shape by cutting the adhered portion.
[0052] The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 270. The inside of the pharmaceutical composition container 260
is provided with a plurality of spaces. The portions between the plurality of spaces
are sealed by a first weak seal portion 300, a second weak seal portion 302 and a
third weak seal portion 304. The first weak seal portion 300 comprises a first weak-seal
zone 310, an intermediate chamber 312 and a second weak-seal zone 314.
[0053] One of the spaces inside the pharmaceutical composition container 260 is the swallowing-aid
substance storage chamber 280. A swallowing-aid substance 40 is stored inside the
swallowing-aid substance storage chamber 280. The first weak-seal zone 310 of the
first weak seal portion 300 easily opens by means of the pressure received from the
swallowing-aid substance 40 when force is applied to the swallowing-aid substance
40 from the outside of the pharmaceutical composition container 260. When the first
weak-seal zone 310 opens, the swallowing-aid substance 40 is pushed out into the intermediate
chamber 312. Thereafter, the second weak-seal zone 314, the second weak seal portion
302 and the third weak seal portion 304 sequentially open in the same way. This can
be realized because the strength of the first weak seal portion 300, the second weak
seal portion 302 and the third weak seal portion 304 is weak compared to that of the
circumferential strong seal portion 270. The reason is the same as in the case of
the embodiment 1, and therefore a detailed explanation thereof will not be repeated
here.
[0054] In one type of the spaces inside the pharmaceutical composition container 260, the
first encapsulating-item storage chamber 282 and the second encapsulating-item storage
chamber 284 exist. An encapsulating item 212 is stored in each of the encapsulating-item
storage chambers. The pharmaceutical composition encapsulated by the encapsulating
item 212 stored in the first encapsulating-item storage chamber 282 and the pharmaceutical
composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item
storage chamber 284 are of different types.
[0055] Further, one of the spaces inside the pharmaceutical composition container 260 is
an aperture chamber 286. The aperture chamber 286 is provided on one end of the pharmaceutical
composition container 260 and serves as the chute (in other words, the device for
dropping the encapsulating item 212 into the mouth of the patient) for the ingestion
of the encapsulating item 212.
[0056] Of the two ends of the pharmaceutical composition container 260, the end on the opposite
side of the end on which the aperture chamber 286 is provided, is the cover 288. The
boundary between the swallowing-aid substance storage chamber 280 and the cover 288
is the bottom strong seal portion 272. The strength of the bottom strong seal portion
272 is the same as that of the circumferential strong seal portion 270; therefore
the bottom strong seal portion 272 is not broken even when force is applied to the
swallowing-aid substance 40 from the outside of the pharmaceutical composition container
260. Note that, in the explanation of the pharmaceutical composition container 260
of this embodiment, the portion which is more to the side of the second encapsulating-item
storage chamber 284 than the cover 288 is referred to as the "container body."
[0057] FIG. 10 is an external view of the portion of the pharmaceutical composition container
260 of this embodiment which corresponds to the rear surface when viewed as shown
in FIG. 9. As is obvious from FIG. 10, a label 262 is adhered to the pharmaceutical
composition container 260 of this embodiment.
<Features Unique to This Embodiment>
[0058] The features unique to the pharmaceutical composition container 260 of this embodiment
as compared to the pharmaceutical composition containers of the other embodiments
are that: the cover 288 is disposed on one end and a cover insert portion 320 which
is inserted into this cover 288 is disposed on the other end; the width of the pharmaceutical
composition container 260 is larger on the base 330 of the portion which is inserted
into the cover 238; the bottom strong seal portion 272 and a portion of the second
weak seal portion 302 or a portion of the third weak seal portion 304 are folded over
to insert the tip of the cover insert portion 320 into the cover 238, and the base
330 is on the outside of the cover 238. FIG. 11 shows the state where the cover insert
portion 320 is inserted into the cover 238 and the base 330 is on the outside of the
cover 238. As is obvious from FIG. 11, the portion of the base 330 is depressed; therefore
it is possible to easily to pull out the cover insert portion 320 by inserting a finger
thereinto. FIG. 12 is a view of the portion which corresponds to the rear surface
when viewed as shown in FIG. 11, in the state shown in FIG. 11. The major part of
the rear surface of the pharmaceutical composition container 260 is occupied by the
label 262.
<Usage Method>
[0059] When using the pharmaceutical composition 260 of this embodiment, a finger is engaged
with the abovementioned base 330 and the abovementioned cover insert portion 320 is
pulled out of the cover 238 in this state. When the cover insert portion 320 is pulled
out, the cover insert portion 320 is placed into the mouth of the patient. The subsequent
usage method is the same as in the other embodiments or alternative embodiments thereof.
<Explanation of the Effect>
[0060] With the pharmaceutical composition container 260 of this embodiment, the cover insert
portion 320 can easily be pulled out because a finger can be engaged with the base
330 of the cover insert portion 320.
[0061] Further, the pharmaceutical composition container 260 of this embodiment produces
the same effects like that of the embodiment 1.
<Embodiment 3>
[0062] The following explains embodiment 3 of this invention. Note that items which are
identical with those explained in the embodiment 1 are given identical reference numerals.
In this embodiment, the detailed explanation thereof will not be repeated.
<Explanation of the Structure>
[0063] FIG. 13 is a partial cross section of the pharmaceutical composition container 400
of this embodiment. Same as in the embodiment 2, the pharmaceutical composition container
400 of this embodiment is formed by double-folding one sheet made of a synthetic resin,
adhering the ends of the double-folded sheet to each other and aligning the outer
shape by cutting the adhered portion.
[0064] The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 410. The inside of the pharmaceutical composition container 400
is provided with a plurality of spaces. The portions between the plurality of spaces
are sealed by a first weak seal portion 440, a second weak seal portion 442 and a
third weak seal portion 444. The first weak seal portion 440 comprises a first weak-seal
zone 450, an intermediate chamber 452 and a second weak-seal zone 454.
[0065] One of the spaces is the swallowing-aid substance storage chamber 420. A swallowing-aid
substance 40 is stored inside the swallowing-aid substance storage chamber 420. When
force is applied to the swallowing-aid substance 40 from the outside of the pharmaceutical
composition container 400, the first weak seal zone 450 and the second weak seal zone
454 sequentially open in the same way as the first weak seal portion 300, the second
weak seal portion 302 and the third weak seal portion 304 in the embodiment 2. The
reason why the first weak seal zone 450 and the second weak seal zone 454 open in
this way is the same as that in the embodiment 2.
[0066] In one type of the spaces inside the pharmaceutical composition container 400, the
first encapsulating-item storage chamber 422 and the second encapsulating-item storage
chamber 424 exist. An encapsulating item 212 is stored in each of the encapsulating-item
storage chambers. The pharmaceutical composition encapsulated by the encapsulating
item 212 stored in the first encapsulating-item storage chamber 422 and the pharmaceutical
composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item
storage chamber 424 are of different types.
[0067] One of the spaces is an aperture chamber 426. Same as the aperture chamber 286 of
the embodiment 2, the aperture chamber 426 serves as a chute for the ingestion of
the encapsulating item 212.
[0068] Of the two ends of the pharmaceutical composition container 400, the end on the opposite
side of the end on which the aperture chamber 426 is provided, is the cover 428. The
boundary between the swallowing-aid substance storage chamber 420 and the cover 478
is the bottom strong seal portion 412. The strength of the bottom strong seal portion
412 is the same as that of the circumferential strong seal portion 410; therefore
the bottom strong seal portion 412 is not broken even when force is applied to the
swallowing-aid substance 40 from the outside of the pharmaceutical composition container
400.
<Features Unique to This Embodiment>
[0069] The features unique to the pharmaceutical composition container 400 of this embodiment
as compared with the pharmaceutical composition containers of the other embodiments
are that: the cover 478 is disposed on one end; the bottom strong seal portion 412
and the base of the portion where the aperture chamber 426 is disposed are folded
over to insert the portion where the aperture chamber 426 is disposed into the cover
478; the tip 480 of the portion where the aperture chamber 426 is disposed is round;
and a part of the edge 482 of the cover 478 is cut out. Note that, in the explanation
of the pharmaceutical composition container 400 of this embodiment, the portion which
is more to the side of the second encapsulating-item storage chamber 424 than the
cover 478 is referred to as the "container body."
<Usage Method>
[0070] When using the pharmaceutical composition 350 of this embodiment, the one of the
two ends of the pharmaceutical composition container 400 on which the aperture chamber
426 is disposed is pulled out of the cover 478. The subsequent usage method is the
same as in the other embodiments.
<Explanation of the Effect>
[0071] During the production of the pharmaceutical composition container 400 of this embodiment,
the pharmaceutical composition container 400 is folded over in such a manner that
the portion where the aperture chamber 426 is disposed and the cut-out edge 482 of
the cover 478 face each other. FIG. 14 shows the state in which pharmaceutical composition
container 400 is folded over during production. After the pharmaceutical composition
container 400 is folded over, the portion where the aperture chamber 426 is disposed
is inserted into the cover 478. At this time, the tip 480 of the portion where the
aperture chamber 426 is disposed gets caught at any position of the cut-out edge 482
of the cover 478 and opens the mouth of the cover 478. Since the mouth of the cover
478 is opened, the tip 480 smoothly enters the inside of the cover 478. FIG. 15 shows
the pharmaceutical composition container 400 after the portion where the aperture
chamber 426 is disposed is inserted into the cover 478.
[0072] Further, the pharmaceutical composition container 400 of this embodiment produces
the same effects like that of the embodiment 1.
<Embodiment 4>
[0073] The following explains embodiment 4 of this invention. Note that items which are
identical with those explained in the embodiment 1 are given identical reference numerals.
In this embodiment, the detailed explanation thereof will not be repeated.
<Explanation of the Structure>
[0074] FIG. 16 is a partial cross section of the pharmaceutical composition container 500
of this embodiment. Same as in the embodiment 2, the pharmaceutical composition container
500 of this embodiment is formed by double-folding one sheet made of a synthetic resin,
adhering the ends of the double-folded sheet to each other and aligning the outer
shape by cutting the adhered portion.
[0075] The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 510. The inside of the pharmaceutical composition container 500
is provided with a plurality of spaces. The portions between the plurality of spaces
are sealed by a first weak seal portion 540, a second weak seal portion 542 and a
third weak seal portion 544. The first weak seal portion 540 comprises a first weak-seal
zone 550, an intermediate chamber 552 and a second weak-seal zone 554.
[0076] One of the spaces inside the pharmaceutical composition container 500 is the swallowing-aid
substance storage chamber 520. A swallowing-aid substance 40 is stored inside the
swallowing-aid substance storage chamber 520. When force is applied to the swallowing-aid
substance 40 from the outside of the pharmaceutical composition container 500, the
first weak seal zone 550 and the second weak seal zone 554 sequentially open in the
same way as the first weak seal portion 300, the second weak seal portion 302 and
the third weak seal portion 304 in the embodiment 2. The reason why the first weak
seal zone 550 and the second weak seal zone 554 open in this way is the same as that
in the embodiment 2.
[0077] In one type of the spaces inside the pharmaceutical composition container 500, the
first encapsulating-item storage chamber 522 and the second encapsulating-item storage
chamber 524 exist. An encapsulating item 212 is stored in each of the encapsulating-item
storage chambers. The pharmaceutical composition encapsulated by the encapsulating
item 212 stored in the first encapsulating-item storage chamber 522 and the pharmaceutical
composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item
storage chamber 524 are of different types.
[0078] One of the spaces is an aperture chamber 526. Same as the aperture chamber 286 of
the embodiment 2, the aperture chamber 526 serves as a chute for the ingestion of
the encapsulating item 212.
[0079] Of the two ends of the pharmaceutical composition container 500, the end on the opposite
side of the end on which the aperture chamber 526 is provided, is the cover 528. The
boundary between the swallowing-aid substance storage chamber 520 and the cover 528
is the bottom strong seal portion 512. The strength of the bottom strong seal portion
512 is the same as that of the circumferential strong seal portion 510; therefore
the bottom strong seal portion 512 is not broken even when force is applied to the
swallowing-aid substance 40 from the outside of the pharmaceutical composition container
500. Note that, in the explanation of the pharmaceutical composition container 500
of this embodiment, the portion which is more to the side of the second encapsulating-item
storage chamber 524 than the cover 528 is referred to as the "container body."
<Features Unique to This Embodiment>
[0080] FIG. 17 is a partial cross section showing one end of the pharmaceutical composition
container 500 during the production thereof. FIG. 18 is a perspective view showing
one end of the pharmaceutical composition container 500 during the production thereof.
The features unique to the pharmaceutical composition container 500 of this embodiment
as compared to the pharmaceutical composition containers of the other embodiments
will be explained while referring to FIG. 17 and FIG. 18. The features thereof are
that: the bottom strong seal portion 512 and the base of the portion where the aperture
chamber 526 is disposed are folded over to insert the portion where the aperture chamber
526 is disposed into the cover 528; and a melt-bonding margin 514 is disposed on the
tip portion 516 which is inserted into the cover 528 on the circumferential strong
seal portion 510. This melt-bonding margin 514 is folded back like shown in FIG. 18
and melt-bonded to the tip portion 516.
<Usage Method>
[0081] The usage method of the pharmaceutical composition container 500 of this embodiment
is the same as that of the embodiment 3.
<Explanation of the Effect>
[0082] Even if there are burrs at the end of the circumferential strong seal portion 510,
those burrs do not easily touch the inside of the mouth of the patient because the
pharmaceutical composition container 500 of this embodiment has a structure like that
mentioned above. Since the burrs do not easily touch the inside of the mouth, the
mouth of the patient is not easily scratched.
[0083] Further, the pharmaceutical composition container 500 of this embodiment produces
the same effects like that of the embodiment 1.
<Embodiment 5>
[0084] The following explains embodiment 5 of this invention. Note that items which are
identical with those explained in the embodiment 1 are given identical reference numerals.
In this embodiment, the detailed explanation thereof will not be repeated.
<Explanation of the Structure>
[0085] FIG. 19 is a partial cross section of the pharmaceutical composition container 210
of this embodiment. Same as in the embodiment 2, the pharmaceutical composition container
210 of this embodiment is formed by double-folding one sheet made of a synthetic resin,
adhering the ends of the double-folded sheet to each other and aligning the outer
shape by cutting the adhered portion.
[0086] The portions where the ends of the sheet are adhered to each other are the circumferential
strong seal portions 220 and 222. The inside of the pharmaceutical composition container
210 is provided with a plurality of spaces. The portions between the plurality of
spaces are sealed by a first weak seal portion 240, a second weak seal portion 242
and a third weak seal portion 244. The first weak seal portion 240 comprises a first
weak-seal zone 250, an intermediate chamber 252 and a second weak-seal zone 254.
[0087] One of the spaces inside the pharmaceutical composition container 210 is the swallowing-aid
substance storage chamber 230. A swallowing-aid substance 40 is stored inside the
swallowing-aid substance storage chamber 230. When force is applied to the swallowing-aid
substance 40 from the outside of the pharmaceutical composition container 260, the
first weak seal zone 250 and the second weak seal zone 254 sequentially open in the
same way as the first weak seal portion 300, the second weak seal portion 302 and
the third weak seal portion 304 in the embodiment 2. The reason why the first weak
seal zone 250 and the second weak seal zone 254 open in this way is the same as that
in the embodiment 2.
[0088] In one type of the spaces inside the pharmaceutical composition container 210, the
first encapsulating-item storage chamber 232 and the second encapsulating-item storage
chamber 234 exist. An encapsulating item 212 is stored in each of the encapsulating-item
storage chambers. The pharmaceutical composition encapsulated by the encapsulating
item 212 stored in the first encapsulating-item storage chamber 232 and the pharmaceutical
composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item
storage chamber 234 are of different types. Further, the outer shape of the encapsulating
items 212 is different from that of the encapsulating item 42 in the embodiment 1.
[0089] Further, one of the spaces inside the pharmaceutical composition container 210 is
an aperture chamber 236. Same as the aperture chamber 286 of the embodiment 2, the
aperture chamber 236 serves as a chute for the ingestion of the encapsulating item
212.
[0090] The pharmaceutical composition 210 of this embodiment is wound in such a manner that
the swallowing-aid substance storage chamber 230 surrounds the aperture chamber 236.
If the pharmaceutical composition container 210 is only wound, it is likely that the
pharmaceutical composition container 210 straightens during the time from the completion
until the use of the pharmaceutical composition container 210; therefore end of the
swallowing-aid substance storage chamber 230 of the wound pharmaceutical composition
container 210 is fixed with a tape 214. FIG. 20 shows the wound pharmaceutical composition
container 210.
<Usage Method>
[0091] To use the pharmaceutical composition container 210 of this embodiment, the tape
214 is peeled off and the pharmaceutical composition container 210 is straightened.
When the pharmaceutical composition container 210 extends straightly, the aperture
chamber 236 is placed into the mouth of the patient. Thereafter the encapsulating
item 212 is ingested in the same way as the embodiment 1 or the alternative embodiments
thereof.
<Explanation of the Effect>
[0092] The pharmaceutical composition container 210 of this embodiment produces the same
effects like that of the embodiment 1.
Industrial Applicability
[0093] The pharmaceutical composition container of this invention is suitable for the use
as, for example, a container for the ingestion of a drug. Specifically, the pharmaceutical
composition container of this invention is suitable for the use as a container for
the ingestion of a drug, wherein the drug is filled into the container by a system
as mentioned below. Such system is one wherein a plurality of auger filling machines
are set up, a transport system and weighing system are added, the filling machines,
the transport system and the weighing system are connected to a medical-drug production
line and automatic operation is performed over a long time.
Explanation of the Reference Numerals
[0094]
10, 11, 12, 14, 15, 16, 18, 210, 260, 400 and 500: pharmaceutical composition container
20: sheet
22: aid-substance storage bag
30, 100, 102, 104, 106, 230, 280 and 520: swallowing-aid substance storage chamber
32 and 110: encapsulating-item storage chamber
34 and 150: outlet chamber
36: first bag storage chamber
38: second bag storage chamber
40: swallowing-aid substance
42, 120 and 212: encapsulating item
50: cutout
60: predetermined aperture part
70, 240, 300, 440 and 540: first weak seal portion
72, 242, 302, 442 and 542: second weak seal portion
74, 220, 222, 270, 410 and 510: circumferential strong seal portion
76, 244, 304, 444 and 544: third weak seal portion
80: pharmaceutical composition
90: patient
112, 232, 282, 422 and 522: first encapsulating-item storage chamber
114, 234, 284, 424 and 524: second encapsulating-item storage chamber
116: empty chamber
130: first tapered portion
140: second tapered portion
214: tape
236, 286, 426 and 526: aperture chamber
238, 288, 428, 478 and 528: cover
250, 310, 450 and 550: first weak seal zone
252, 312, 452 and 552: intermediate chamber
254, 314, 454 and 554: second weak seal zone
262: label
272, 412 and 512: bottom strong seal portion
320: cover insert portion
330: base
480: tip
482: edge
516: tip portion